The interplay between diet and the gut microbiome: implications for health and disease

Nature Reviews Microbiology, Journal Year: 2024, Volume and Issue: 22(11), P. 671 - 686

Published: July 15, 2024

Language: Английский

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Therapeutics for neurodegenerative diseases by targeting the gut microbiome: from bench to bedside

Translational Neurodegeneration, Journal Year: 2024, Volume and Issue: 13(1)

Published: Feb. 27, 2024

The aetiologies and origins of neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's (PD), amyotrophic lateral sclerosis (ALS) Huntington's (HD), are complex multifaceted. A growing body evidence suggests that the gut microbiome plays crucial roles in development progression diseases. Clinicians have come to realize therapeutics targeting potential halt This narrative review examines alterations AD, PD, ALS HD, highlighting close relationship between brain Processes mediate microbiome-brain communication including immunological, vagus nerve circulatory pathways, evaluated. Furthermore, we summarize for diseases modify its metabolites, diets, probiotics prebiotics, microbial antibacterials faecal transplantation. Finally, current challenges future directions discussed.

Language: Английский

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The gut microbiota-immune-brain axis: Therapeutic implications

Cell Reports Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 101982 - 101982

Published: March 1, 2025

Language: Английский

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Gut Microbiome, Diet and Depression: Literature Review of Microbiological, Nutritional and Neuroscientific Aspects

Current Nutrition Reports, Journal Year: 2025, Volume and Issue: 14(1)

Published: Feb. 10, 2025

Abstract Purpose of Review This review explores the intricate relationships among gut microbiota, dietary patterns, and mental health, focusing specifically on depression. It synthesizes insights from microbiological, nutritional, neuroscientific perspectives to understand how gut-brain axis influences mood cognitive function. Recent Findings studies underscore central role microbiota in modulating neurological psychological health via axis. Key findings highlight importance components, including probiotics, prebiotics, psychobiotics, restoring microbial balance enhancing regulation. Different patterns exhibit a profound impact composition, suggesting their potential as complementary strategies for support. Furthermore, mechanisms like tryptophan metabolism, HPA axis, metabolites such SCFAs are implicated linking diet Clinical trials show promising effects probiotics alleviating depressive symptoms. Summary illuminates diet-based interventions targeting mitigate depression improve health. While interplay between diversity, diet, brain function offers therapeutic avenues, further clinical research is needed validate these establish robust, individualized treatment strategies.

Language: Английский

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The Impact of Stress and Social Determinants on Diet in Cardiovascular Prevention in Young Women

Nutrients, Journal Year: 2024, Volume and Issue: 16(7), P. 1044 - 1044

Published: April 3, 2024

The prevention of cardiovascular diseases is a fundamental pillar for reducing morbidity and mortality caused by non-communicable diseases. Social determinants, such as socioeconomic status, education, neighborhood, physical environment, employment, social support networks, access to health care, play crucial role in influencing outcomes inequities within populations. determinants stress women are interconnected factors that can significantly impact women’s well-being. Pregnancy good time engage young introduce them beneficial behaviors, adopting essential life skills, especially diet, learning management techniques. Stress influences more likely unhealthy eating behaviors emotional or coping with food. Strong action needed improve lifestyle starting at age considering this lays the foundation lower risk adults elderly. objective review examine primary healthy women, focusing particularly on unresolved issues influence well correlation stressors their diet.

Language: Английский

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Precision Psychobiotics for Gut–Brain Axis Health: Advancing the Discovery Pipelines to Deliver Mechanistic Pathways and Proven Health Efficacy

Microbial Biotechnology, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 1, 2025

ABSTRACT Advancing microbiome–gut–brain axis science requires systematic, rational and translational approaches to bridge the critical knowledge gaps currently preventing full exploitation of gut microbiome as a tractable therapeutic target for gastrointestinal, mental brain health. Current research is still marked by many open questions that undermine widespread application humans. For example, lack mechanistic understanding probiotic effects means it remains unclear why even apparently closely related strains exhibit different in vivo. live microbial psychobiotics, consensus on their adjunct treatments conventional neuromodulators, use unmedicated populations or at‐risk cohorts with sub‐clinical symptomatology warranted. This missing information both sides equation when treating central nervous system (CNS) conditions makes psychobiotic challenging, especially compared other pharmaceutical functional food approaches. Expediting transition from positive preclinical data proven benefits humans includes interpreting promises pitfalls animal behavioural assays, well navigating mechanism‐informed decision making select right microbe(s) job. In this review, we consider how these decisions can be supported light accrued range clinical studies across healthy, pathological study populations, where specific have been evaluated context gastrointestinal physiology, function behaviour. Examples successful, partial unsuccessful translation bench bedside are considered. We also discuss developments silico analyses enhanced our moved towards pinpointing host–microbe interactions most important optimal gut–brain function. Combining assays vitro ex vivo domains incorporating model organisms prime discovery pipelines promising rationally selected candidates.

Language: Английский

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The Inflammatory Mechanism of Parkinson’s Disease: Gut Microbiota Metabolites Affect the Development of the Disease Through the Gut–Brain Axis

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 159 - 159

Published: Feb. 6, 2025

Parkinson's disease is recognized as the second most prevalent neurodegenerative disorder globally, with its incidence rate projected to increase alongside ongoing population growth. However, precise etiology of remains elusive. This article explores inflammatory mechanisms linking gut microbiota disease, emphasizing alterations in and their metabolites that influence disease's progression through bidirectional transmission signals along gut-brain axis. Building on this mechanistic framework, further discusses research methodologies treatment strategies focused metabolites, including metabolomics detection techniques, animal model investigations, therapeutic approaches such dietary interventions, probiotic treatments, fecal transplantation. Ultimately, aims elucidate relationship between underlying thereby paving way for novel avenues condition.

Language: Английский

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Understanding Microbial Mediation of the Brain-Gut Axis

Gastroenterology Clinics of North America, Journal Year: 2025, Volume and Issue: 54(2), P. 367 - 381

Published: Feb. 7, 2025

Language: Английский

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Exploring Therapeutic Potential of Phytoconstituents as a Gut Microbiota Modulator in the Management of Neurological and Psychological Disorders

Neuroscience, Journal Year: 2024, Volume and Issue: 551, P. 69 - 78

Published: May 14, 2024

Language: Английский

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Electroacupuncture alleviates functional constipation by upregulating host-derived miR-205-5p to modulate gut microbiota and tryptophan metabolism

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 5, 2025

Electroacupuncture (EA) has shown promise as a treatment for Functional constipation (FC), with growing evidence suggesting it may enhance gut motility. MicroRNAs (miRNAs) serve key regulatory molecules mediating host-microbiota interactions. However, the specific fecal miRNAs regulating microbiota composition and metabolism in EA-treated constipated mice, along their targets, remain unidentified. We examined microbiome composition, metabolism, colonic miRNA expression loperamide-induced mice to identify differentially expressed assess relationships microbial abundance, An antibiotic cocktail adeno-associated virus were employed interfere target vivo, thereby validating proposed mechanism. Our results indicate that miR-205-5p, significantly upregulated tissues of promotes intestinal motility microbiome-dependent manner. Specifically, EA promoted growth Lactobacillus reuteri , enriched feces constipation-recovered through host-derived miR-205-5p regulation. Furthermore, its tryptophan metabolites (indole-3-acetamide, indole-3-acetic acid, indole-3-carboxaldehyde) alleviated constipation. These findings underscore pivotal role modulating EA.

Language: Английский

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