Exploring Maternal Diet-Epigenetic-Gut Microbiome Crosstalk as an Intervention Strategy to Counter Early Obesity Programming

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(5), P. 4358 - 4378

Published: May 6, 2024

Alterations in a mother’s metabolism and endocrine system, due to unbalanced nutrition, may increase the risk of both metabolic non-metabolic disorders offspring’s childhood adulthood. The obesity offspring can be determined by interplay between maternal nutrition lifestyle, intrauterine environment, epigenetic modifications, early postnatal factors. Several studies have indicated that fetal bowel begins colonize before birth that, during nursing, gut microbiota continues change. is primarily transferred fetus through environment. In this way, it able impact establishment neonatal microbiome, resulting signatures possibly predispose development later life. However, antioxidants exercise mother been shown improve metabolism, with improvements leptin, triglycerides, adiponectin, insulin resistance, as well weight mechanisms. Therefore, extensive literature review, we aimed investigate relationship diet, epigenetics, order expand on current knowledge identify novel potential preventative strategies for lowering children adults.

Language: Английский

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Nutritional senolytics and senomorphics: Implications to immune cells metabolism and aging – from theory to practice

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: Sept. 8, 2022

Aging is a natural physiological process, but one that poses major challenges in an increasingly aging society prone to greater health risks such as diabetes, cardiovascular disease, cancer, frailty, increased susceptibility infection, and reduced response vaccine regimens. The loss of capacity for cell regeneration the surrounding tissue microenvironment itself conditioned by genetic, metabolic, even environmental factors, nutrition. senescence immune system (immunosenescence) represents challenge, especially when associated with presence age-related chronic inflammation (inflammaging) affecting metabolic programming cells (immunometabolism). These aspects are linked poorer outcomes therefore present opportunity host-directed interventions aimed at both eliminating senescent curbing underlying inflammation. Senotherapeutics class drugs products delay, prevent, or reverse process – senolytics; inhibit senescence-associated secretory phenotype senomorphics. Natural senotherapeutics from food sources nutritional may constitute interesting way achieve better age-associated through personalized In this sense, authors herein framework intervention targeting immunosenescence immunometabolism, identifying research gaps area, gathering information on concluded ongoing clinical trials subject. Also, we future directions ideation possibilities field.

Language: Английский

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Unravelling the Complex Relationship between Diet and Nephrolithiasis: The Role of Nutrigenomics and Nutrigenetics

Nutrients, Journal Year: 2022, Volume and Issue: 14(23), P. 4961 - 4961

Published: Nov. 23, 2022

Nephrolithiasis is an increasingly prevalent condition, especially in high income countries, and associated with morbidity. Extraordinary progress genetics made the identification of genetic forms nephrolithiasis possible. These diseases are usually rare do not account for most common that result several factors such as environment, dietary habits, predisposing genes. This knowledge has shaped what we classify nephrolithiasis, a condition now recognized systemic. How to extent all these interact one another end kidney stone formation, growth, recurrence completely understood. Two new research fields have recently been trying give some answers: nutrigenomics nutrigenetics. aim understanding intricate diet/genome interface influences gene expression regulation mainly through epigenetic mechanisms results specific medical conditions cancer, metabolic syndrome, cardiovascular diseases. Epigenetics seems play crucial role could represent link between environmental factors, constantly exposed to, risk nephrolithiasis. In this systematic review, summarize available evidence proven or hypothesized related

Language: Английский

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Climate change and epigenetic biomarkers in allergic and airway diseases

Journal of Allergy and Clinical Immunology, Journal Year: 2023, Volume and Issue: 152(5), P. 1060 - 1072

Published: Sept. 22, 2023

Human epigenetic variation is associated with both environmental exposures and allergic diseases can potentially serve as a biomarker connecting climate change allergy airway diseases. In this narrative review, we summarize recent human studies examining exposure to temperature, precipitation, extreme weather events, malnutrition discuss findings they relate Temperature has been the most widely studied exposure, implicating short-term long-term alterations aging. Few have examined natural disasters or events. The available reported differential DNA methylation of multiple genes pathways, some which were previously asthma allergy. integrated climate-related biomarkers, disease together. Prospective longitudinal are needed along collection target tissues beyond blood samples, such nasal skin cells. Finally, global collaboration increase diverse representation study participants, particularly those affected by injustice, well strengthen replication, validation, harmonization measurements will be elucidate impacts on epigenome. crisis one greatest threats humanity, significant allergic, immunologic, respiratory health.1Watts N. Amann M. Arnell Ayeb-Karlsson S. Belesova K. Boykoff et al.The 2019 report Lancet Countdown Health Climate Change: ensuring that health child born today not defined changing climate.Lancet. 2019; 394: 1836-1878Abstract Full Text PDF PubMed Scopus (825) Google Scholar, 2D'Amato G. Holgate S.T. Pawankar R. Ledford D.K. Cecchi L. Al-Ahmad al.Meteorological conditions, change, new emerging factors, related disorders. A statement World Allergy Organization.World Organ J. 2015; 8: 25Abstract (352) 3Katelaris C.H. Beggs P.J. change: allergens diseases.Intern Med 2018; 48: 129-134Crossref (73) 4D'Amato Chong-Neto H.J. Monge Ortega O.P. Vitale C. Ansotegui I. Rosario effects induced pollen mold allergens.Allergy. 2020; 75: 2219-2228Crossref (160) 5Sampath V. Aguilera Prunicki Nadeau K.C. Mechanisms air pollution immune system leading asthma.Semin Immunol. 2023; 67101765Crossref (2) Scholar primary driver production consumption fossil fuels—coal, crude oil, gas—which emit greenhouse gasses, carbon monoxide methane.1Watts Scholar,6Rossati A. Global warming its impact.Int J Occup Environ Med. 2017; 7-20Crossref (169) average surface temperature planet risen since preindustrial times largely because fuel use, it predicted continue increasing unless immediate efforts reduce use take place. As result, there precipitation patterns, increased frequency like wildfires hurricanes, in land patterns.6Rossati 7Hashim J.H. Hashim Z. implications Asia Pacific Region.Asia Pac Public Health. 2016; 28: 8S-14SCrossref (68) 8Ebi K.L. Vanos Baldwin J.W. Bell J.E. Hondula D.M. Errett N.A. al.Extreme population implications.Annu Rev 2021; 42: 293-315Crossref (183) burning fuels also water UV radiation exposure.9D'Amato Bergmann Annesi-Maesano Sanduzzi Liccardi al.Climate pollution.Allergo Int. 2014; 23: 17-23Crossref (33) 10Kinney P.L. quality, health.Am Prev 2008; 35: 459-467Abstract (284) 11Bais A.F. McKenzie R.L. Bernhard Aucamp Ilyas Madronich al.Ozone depletion radiation.Photochem Photobiol Sci. 14: 19-52Crossref These climatic changes our linked increases risk for wide range outcomes, including heat stroke, vector-borne illnesses, cardiopulmonary diseases, malnutrition, psychiatric conditions.12Rocque R.J. Beaudoin Ndjaboue Cameron Poirier-Bergeron Poulin-Rheault R.A. al.Health an overview systematic reviews.BMJ Open. 11e046333Crossref (306) Scholar,13Salas R.N. Solomon C.G. crisis—health care delivery.N Engl Aug 22; 381: e13Crossref (40) Relevant allergy, atmospheric conditions regions, may lead spread sources intensity duration generation.4D'Amato Scholar,14Singh A.B. Kumar P. diseases: overview.Front Allergy. 2022; 3964987Crossref Scholar,15Luschkova D. Traidl-Hoffmann Ludwig allergies.Allergo 31: 114-120Crossref (18) Therefore, more could burden epigenome lies at intersection between factors Epigenetic refer gene expression directly underlying genetic code. They allow us better characterize early biomarkers impact from their connection health.16Harb H. Renz Update epigenetics disease.J Clin 135: 15-24Abstract (80) Scholar,17Potaczek D.P. Harb Michel Alhamwe B.A. Tost Epigenetics allergy: basic mechanisms clinical applications.Epigenomics. 9: 539-571Crossref (191) marks tissue cell type specific, yield insights into responses specific organs. epidemiologic studies, once extracted (often mixed cells subject), measured after bisulfite treatment using sequencing microarrays (eg, 450K 850K/EPIC Illumina arrays [Illumina, San Diego, Calif]). commonly modification cytosine nucleotides (cytosine-phosphate-guanine dinucleotide [CpG] sites).16Harb Analytic strategies include epigenome-wide analysis, candidate approaches, testing aging, composition estimation, identification smoking) health.18Yousefi P.D. Suderman Langdon Whitehurst O. Davey Smith Relton C.L. methylation-based predictors health: applications statistical considerations.Nat Genet. 369-383Crossref (36) methodologies used highlighting potential biologic pathways development factors19Melén E. Koppelman G.H. Vicedo-Cabrera A.M. Andersen Z.J. Bunyavanich Allergies food airborne children adolescents: role environment.Lancet Child Adolesc 6: 810-819Abstract (17) 20Somineni H.K. Zhang X. Biagini Myers J.M. Kovacic M.B. Ulm Jurcak al.Ten-eleven translocation 1 (TET1) childhood traffic-related pollution.J 137: 797-805.e5Abstract (98) 21Cardenas Fadadu R.P. Van Der Laan Ward-Caviness Granger Diaz-Sanchez al.Controlled diesel exhaust: experiment bronchial epithelial cells.Environ Epigenetics. 7: dvab003Crossref (7) 22McDonald-Hyman Tager modifications Foxp3 locus exposed high levels ambient 2010; 125: AB356Abstract immunologic components aging.23Peng Cardenas Rifas-Shiman S.L. Hivert M.F. Gold D.R. Platts-Mills T.A. al.Epigenetic age acceleration Project Viva.J 143: 2263-2270.e14Abstract (39) Scholar,24Cardenas Sordillo Chung W. Liang Coull methylome inflammation children.Nat Commun. 10: 3095Crossref (109) Harnessing power field immunology provide how affect health. Although humidity, less than has,19Melén Scholar,25Ji Brandt E.B. Brokamp Ryan P.H. Khurana Hershey G.K. Air pollution, epigenetics, asthma.Allergy Asthma 12: 51Crossref (45) research plant animal models shown these ways.26Gugger P.F. Fitz-Gibbon PellEgrini Sork V.L. Species-wide patterns Quercus lobata association gradients.Mol Ecol. 25: 1665-1680Crossref (112) 27Weyrich Benz Karl Jeschek Jewgenow Fickel Paternal causes Stat3 wild guinea pig sons.Ecol Evol. 2657-2666Crossref (25) 28Weyrich Lenz Environmental change-dependent inherited response.Genes. 4Crossref 29Marsh A.G. Pasqualone A.A. stress Antarctic polychaete, Spiophanes tcherniai.Front Physiol. 5: 173Crossref (66) 30Skjærven K.H. Hamre Penglase Finn Olsvik P.A. Thermal alters involved Atlantic cod embryos.Comp Biochem Physiol Mol Integr 173C: 17-27Crossref (35) review regarding was conducted identified 15 status TLR2 NOS2).31Xu Li Guo Zhao Q. Abramson M.J. al.Environmental modifications: review.Environ Pollut. 259113840Crossref (30) However, did examine other factors. objective article first investigating change-associated exposures, We strengths, challenges, opportunities future topic. For online search original articles published topic exposures. This included mechanisms, methylation, histone modifications, non-coding RNAs, various disasters. performed 3 databases—PubMed, Web Science, EMBASE—for January 1, 2000, August 2023, combination Medical Subject Headings (MeSH) terms listed Table relevant discussed following sections organized interpretation connections outcomes. Data markers and/or annotations when available, E1 (in Online Repository www.jacionline.org). section focused recently evaluated topic, 2020.31Xu major cause direct associations excluded reviewed extensively.25Ji Scholar,32Saenen N.D. Martens D.S. Neven K.Y. Alfano Bové Janssen B.G. al.Air pollution-induced placental alterations: interplay oxidative stress, aging phenotype?.Clin 11: 124Crossref (103) Scholar,33Rider C.F. Carlsten methylation: humans.Clin 131Crossref (168) ScholarTable IDescription strategy articlesParameterDetailsDates searchJanuary 2023DatabasesPubMed, EMBASE, ScienceSearch terms"epigenetics," "epigenome," "methylome," "DNA methylation," "histone," "non-coding RNA," "temperature," "thermal," "global warming," "climate," "radiation," "humidity," "hurricane," "flooding," "heat," "wildfires," "extreme weather," temperature," "heat wave," "blizzard," "thunderstorm," "tornado," "malnutrition," "famine" Open table tab goal investigate contribute variation, prevalence, incidence, severity It important note different stages life (such utero, childhood, adulthood), differentially play affecting variability methylation.34Li Ye Mather K.A. Nguyen T.L. Dite G.S. Armstrong N.J. al.Early affects late-life through determining across lifespan: twin study.EBioMedicine. 77103927Abstract (9) particular, utero susceptible window, programming cells, organs, established during period.35Kohli R.M. Y. TET enzymes, TDG dynamics demethylation.Nature. 2013; 502: 472-479Crossref (1157) Additionally, ancestry-specific quantitative trait loci (meQTL) support inclusion ancestrally multiethnic populations studies. reflect progression, so samples key distinguishing might characterized cross-sectional (Fig 1). There several research, found literature II. step involves extraction tissues, whole blood, skin, epithelium. Once processed, analyzed variety methods, arrays.36Rauluseviciute Drabløs F. Rye data sequencing: experimental approaches recommendations tools pipelines analysis.Clin 193Crossref (52) 850K EPIC BeadChips (EWASs) systematically measure CpG sites genome large cohorts.37Campagna M.P. Xavier Lechner-Scott Maltby Scott Butzkueven al.Epigenome-wide studies: current knowledge, recommendations.Clin 13: 214Crossref Then, bioinformatic test phenotypes interest. common approach each individually all measurements, often referred methylated position. complemented entire proximity correlation structure, region (DMR) CpGs. technique assess relationship asthma, diseases.38Cardenas Epigenome-wide environment.J 152: 582-590Abstract (3) targeted selecting certain priori primers array panel inflammation) analyzing sites. An example farm milk contributed FOXP3 regulatory T (Treg) decreased atopic sensitization childhood.39Lluis Depner Gaugler B. Saas Casaca V.I. Raedler al.Increased T-cell numbers lower childhood.J 133: 551-559.e10Abstract newer methodology clocks, morbidity mortality.40Horvath Raj clock theory ageing.Nat 19: 371-384Crossref (1238) estimate predictive individual's chronologic age. Deviation measures (EAA), strong factor mortality (including due diseases) influenced example, cigarette smoking EAA among adults,41Cardenas Ecker Huen Orozco McEwen L.M. Costa Rican adults.Sci Rep. 4277Crossref (15) another showed greater higher odds having atopy allergen sensitization.23Peng IIDefinition researchTermDefinitionEWASA comprehensive genome-wide interestCpG siteDNA dinucleotides followed guanine nucleotide methyl group added methyltransferase, alter transcriptionDMRAn genomic composed samplesNon-coding RNAsFunctional molecules RNA translated proteins but protein functioningEpigenetic clocksStatistical calculators derive age, marker correlated mortalityEAADeviations calculated residuals output regressed participantmeQTLsSingle-nucleotide polymorphisms sitemeQTL, Methylation locus. meQTL, Most smoke results discordant, many EWASs frequently near promoters AHRR, FOXP3, IL4.33Rider Scholar,42Knopik V.S. Maccani M.A. Francazio McGeary maternal pregnancy development.Dev Psychopathol. 2012; 24: 1377-1390Crossref (203) Scholar,43Mukherjee Dasgupta Mishra P.K. Chaudhury changes: possible link hypersensitivity pneumonitis.Environ Sci Pollut Res 55981-56002Crossref (19) regions influence expression, AHRR methylation.44Reynolds Wan Ding Taylor J.R. Lohman Su al.DNA aryl hydrocarbon receptor repressor subclinical atherosclerosis.Circ Cardiovasc 707-716Crossref (92) Scholar,45Tsai P.C. Glastonbury C.A. Eliot M.N. Bollepalli Yet Castillo-Fernandez al.Smoking induces coordinated adipose consequences metabolic health.Clin 126Crossref (79) emerged mostly designs, limited timing directionality clear. Nonetheless, methodologic advancements show promise elucidating improve prevention treatment. Epidemiologic aggravated famine drought. tested isolated leukocytes. sections, place context microRNAs (miRNAs) outcome interest, whereas rest methylation; none them investigated modifications. Exposures chronic acute, mortality, (Table III).46Ebi Capon Berry Broderick Dear R de Havenith al.Hot extremes: risks.Lancet. 398: 698-708Abstract (311) linking fluctuations IV). responsiveness activating transient cation channels stimulating cholinergic reflex pathways.47Millqvist TRP disease—clinical significance.Temperature. 2: 172-177Crossref (16) membrane fluidity disruption transmembrane structural inflammatory response. Regarding temperature-related alterations, before 2020 summarized 7 genes31Xu Scholar; topic.Table IIISummary precipitationStudy titleAuthors (y)LocationPopulationExposureEpigenetic end pointKey finding(s)Temperature EWAS Short-Term FluctuationsBased Within-Sibship Analyses Australian FemalesWu al (2023)AustraliaAdult female twins sisters AMDTSSShort-term temperatureDNA (EWAS) peripheral leukocytes BeadChip-Temperature 14 CpGs 70 DMRs mapping 68 Associations Medium- Long-Term Exposure EAANi (2023)Augsburg, GermanyKORALa

Language: Английский

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On how to feed critically ill children in intensive care: a slowly shifting paradigm

Clinical Nutrition, Journal Year: 2025, Volume and Issue: 46, P. 169 - 180

Published: Feb. 6, 2025

Critically ill children requiring treatment in a pediatric intensive care unit (PICU) suffer from anorexia and/or feeding intolerance. The resulting macronutrient deficit associates with poor outcome. Until recently, this association formed the basis for initiating enteral or parenteral early to improve multicenter "Early-versus-Late-Parenteral-Nutrition-in-the-Pediatric-Intensive-Care-Unit" randomized controlled trial (PEPaNIC-RCT) addressed whether is causal. It showed that supplementation of insufficient/contraindicated nutrition nutrition, as compared accepting throughout first week PICU, did not On contrary, it caused more infections and prolonged organ support PICU stay, adversely affected neurodevelopmental outcomes 2 4 years later. Harm was present all subgroups appeared explained by dose, specifically amino-acid lipid glucose doses. These findings corroborated results large-scale adult RCTs. Mechanisms harm enhanced comprised suppressed cellular repair pathways like autophagy ketogenesis, illness-induced alterations thyroid hormone metabolism, iatrogenic hyperglycemia, increased urea cycle activity through anabolic resistance, induction epigenetic modifications mediate longer-term developmental impairments. came unexpected many intensivists. Hence, paradigm has only slowly begun shift toward restrictive administration acute phase critical illness. Benefits fasting responses have become clear, provided micronutrients are given prevent deficiencies refeeding syndrome. insights open perspectives studies investigating novel nutritional strategies activate fasting-induced while avoiding starvation.

Language: Английский

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Metabolic reprogramming in cancer and senescence

MedComm, Journal Year: 2025, Volume and Issue: 6(3)

Published: March 1, 2025

The rising trend in global cancer incidence has caused widespread concern, one of the main reasons being aging population. Statistical data show that and mortality rates a clear upward with age. Although there is commonality between dysregulated nutrient sensing, which features aging, metabolic reprogramming tumor cells, specific regulatory relationship not clear. This manuscript intends to comprehensively analyze senescence reprogramming; as well reveal impact key factors leading cellular on tumorigenesis. In addition, this review summarizes current intervention strategies targeting sensing pathways, clinical cases treating tumors characteristics existing nanodelivery research strategies. Finally, it also suggests sensible dietary habits for those who wish combat aging. conclusion, attempts sort out link metabolism provide new ideas treatment.

Language: Английский

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Association between Childhood Hunger and Depression or Anxiety in Later Life: Insights from Two Case-Control Studies

Psychiatry Research, Journal Year: 2025, Volume and Issue: unknown, P. 116475 - 116475

Published: March 1, 2025

Language: Английский

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Diet quality, food security and traditional food intake of pregnant and breastfeeding women, and children 6 months to 5 years, living in eight remote Australian Aboriginal and Torres Strait Islander communities

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 1, 2025

Maternal and early childhood nutrition is foundational in setting the course for lifetime metabolic disease outcomes. Food security influences achievement of optimal diets; however, little known about how traditional food intake may influence this dynamic Aboriginal Torres Strait Islander people living remote communities. This study describes diets status pregnant breastfeeding women children 6 months to 5 years communities Australia, explores interactions between diet quality, consumption. Baseline data from a trial testing discount on healthy foods drinks were used. Participants eight (four each coastal Cape York, Queensland desert Central Northern Territory) participated June-September 2021. A validated frequency questionnaire was used assess usual calculate quality score. modified version United States Department Agriculture 18-item Household Security Scale Module measured status. model fitted explore Complete dietary available 471 participants 294 households. Average reported group intakes similar recommended patterns, however except adequate meat those not; mean scores 23% higher than (p < 0.001). Long-duration described (36% > 2-4 breastfed). High rates household insecurity (76%), although lower York Reported Australia For significant three-way interaction status, adult/child demonstrated = 0.005). Remote community families carry out practices that protect support despite conditions challenge diets. The role consumption reducing impact provides further evidence systems be at centre comprehensive efforts address insecurity. work part has been registered with Australian New Zealand Clinical Trials Registry: ACTRN12621000640808. Trial registration date: 28/05/2021.

Language: Английский

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A Murine Model of Maternal Micronutrient Deficiencies and Gut Inflammatory Host-microbe Interactions in the Offspring

Cellular and Molecular Gastroenterology and Hepatology, Journal Year: 2024, Volume and Issue: 17(5), P. 827 - 852

Published: Jan. 1, 2024

Micronutrient deficiency (MND) (ie, lack of vitamins and minerals) during pregnancy is a major public health concern. Historically, studies have considered micronutrients in isolation; however, MNDs rarely occur alone. The impact co-occurring on health, mainly shaping mucosal colonization by pathobionts from the Enterobacteriaceae family, remains undetermined due to relevant animal models. To establish maternal murine model multiple MND (MMND), we customized diet deficient (A, B12, B9) minerals (iron zinc) that most commonly affect children women reproductive age. Thereafter, adherence Enterobacteriaceae, associated inflammatory markers, proteomic profile intestines were determined offspring MMND mothers (hereafter, low micronutrient [LM] pups) via bacterial plating, flow cytometry, mass spectrometry, respectively. For human validation, abundance, assessed 16s sequencing 3-month-old infant fecal samples (n = 100), was correlated with metabolites using Spearman's correlation meconium CHILD birth cohort. We developed an reported increase colonic abundance LM pups at weaning. Findings cohort confirmed negative between availability. Furthermore, pro-inflammatory cytokines increased infiltration lymphocyte antigen 6 complex high monocytes M1-like macrophages evident colons pups. Mechanistically, mitochondrial dysfunction marked reduced expression nicotinamide adenine dinucleotide (NAD)H dehydrogenase NAD phosphate oxidase (Nox) 1 contributed bloom. This study establishes early life link intestinal pathobiont inflammation damaged mitochondria offspring.

Language: Английский

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The supplementation of female dogs with live yeast Saccharomyces cerevisiae var. boulardii CNCM I-1079 acts as gut stabilizer at whelping and modulates immunometabolic phenotype of the puppies

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: April 12, 2024

Time around parturition is a stressful period for both bitches and their puppies. The use of probiotics has been proposed, e.g., in pigs, to improve health status sows, reproductive performances turn, the performance progeny. objective present study was evaluate impact, on dams puppies, supplementation with live yeast Saccharomyces cerevisiae var. boulardii CNCM I-1079 (SB-1079) during second part gestation lactation period. A total 36 medium large-sized breeds were enrolled. They divided into two groups, one which received 1.3 × 10 9 colony forming units per day. At dam’s level, SB-1079 shaped different microbiota structure between groups just after whelping, impacted alpha diversity some plasma metabolites related energy metabolism. Regarding performances, improved gross colostrum (1.4 vs. 1.2 kcal ME/g) as well concentration protein milk at Day 7 (10.4 7.6%). also reduced odds having low birth weight litter. puppy’s modulation immunometabolic phenotype suggested by observation increased growth rates early pediatric (i.e., 21 56 days life, 225 190%) decrease IL-8:IL-10 ratio vaccination against rabies (4.2 16.9). Our findings suggest that potential enhance turn puppies through maternal programming.

Language: Английский

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