Advanced glycation end-product intake predicts insulin resistance in a sex-dependent fashion

European Journal of Nutrition, Journal Year: 2025, Volume and Issue: 64(4)

Published: April 22, 2025

Abstract Purpose Dietary advanced glycation end products (AGEs) have been implicated in promoting insulin resistance. However, their impact on resistance a mixed population made up of males and females remains controversial. The aim this study was to evaluate whether the relationship between dietary AGEs may be sex-dependent. Methods 195 239 were included cross-sectional study. Study participants underwent anthropometric metabolic assessments. AGE intake estimated using food frequency questionnaires databases reporting content individual items. resistance, HOMA-IR, assessed Pearson correlation test. predictive power towards HOMA-IR investigated stepwise linear regression. Results correlated positively with (p < 0.01) but not male > 0.05). Moreover, able increase BMI males. Instead, variables only discriminants predict Conclusion exert sex-dependent effect as is associated This suggests that more susceptible deleterious these glycotoxins sensitivity. Nevertheless, considering involving nutritional intervention directly elucidate sex-dependent, further studies are warranted confirm present findings.

Language: Английский

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Unraveling the Evolutionary Diet Mismatch and Its Contribution to the Deterioration of Body Composition

Metabolites, Journal Year: 2024, Volume and Issue: 14(7), P. 379 - 379

Published: July 7, 2024

Over the millennia, patterns of food consumption have changed; however, foods were always whole foods. Ultra-processed (UPFs) been a very recent development and become primary source for many people. The purpose this review is to propose hypothesis that, forsaking evolutionary dietary environment, its complex milieu compounds resulting in an extensive metabolome, contributes chronic disease modern humans. This metabolome may contributed success early hominins. based on following assumptions: (1) promote health, (2) essential nutrients cannot explain all benefits foods, (3) UPFs are much lower phytonutrients other compared (4) diets more diverse metabolome. Evidence will be presented support hypothesis. Nutrition matter systems biology, investigating as humans, help elucidate hidden connections between diet health. effect also shape future guidelines, define healthy

Language: Английский

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Higher consumption of ultra‐processed foods is associated with higher odds of overweight and obesity amongst under‐five children: A national cross‐sectional study in Lebanon

Pediatric Obesity, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 24, 2024

Summary Introduction Limited evidence exists on the relationship between ultra‐processed food (UPF) consumption and overweight/obesity amongst young children. This study aimed to assess UPF consumption, its socioeconomic correlates association with under‐five children in Lebanon. Materials Methods Data pertinent aged 6 months 4.9 years ( n = 893) from a cross‐sectional national survey were used. Anthropometric measurements obtained, multi‐component questionnaires administered mothers. Dietary intake was assessed using 24‐h recall approach. NOVA classification used assign items into four groups according extent of industrial processing. Contributions each group total energy (EI) macronutrient micronutrient intakes estimated. Regression models conducted explore as well status. Results UPFs found contribute 47% daily EI. Girls higher household income had significantly intakes. Children whose mothers an intermediate, high school, or technical diploma employed fathers education levels consumed less EI UPFs. %EI fell within second third tertiles odds compared those first tertile (adjusted ratio [AOR]: 1.21, 95% confidence interval [CI]: 1.09, 1.32 AOR: 1.61, CI: 1.47, 1.76, respectively), after adjusting for confounders. Conclusion The coupled call public health nutrition interventions at improving feeding dietary practices this age group.

Language: Английский

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Mediterranean Diet and Ultra-Processed Food Intake in Older Australian Adults—Associations with Frailty and Cardiometabolic Conditions

Nutrients, Journal Year: 2024, Volume and Issue: 16(17), P. 2978 - 2978

Published: Sept. 3, 2024

Dietary patterns contribute to overall health and diseases of ageing but are understudied in older adults. As such, we first aimed develop dietary indices quantify Mediterranean Diet Score (MDS) utilisation Ultra-processed Food (UPF) intake a well-characterised cohort relatively healthy community-dwelling Australian Second, understand the relationship between these scores association with prevalent cardiometabolic disease frailty. Our major findings that this population adults, (a) pre-frailty frailty associated reduced MDS increased UPF intake; (b) adherence eating does not preclude high (and vice versa); (c) an pattern prevent risk higher intakes. should be encouraged adults potentially reduce frailty, while impact further explored given convenience foods provide whose access unprocessed food may limited due socioeconomic, health, lifestyle factors.

Language: Английский

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Association between consumption of nonessential energy-dense food and body mass index among Mexican school-aged children: a prospective cohort study

International Journal of Obesity, Journal Year: 2024, Volume and Issue: 48(9), P. 1292 - 1299

Published: June 8, 2024

Language: Английский

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Association of ultra-processed foods intake with untargeted metabolomics profiles in adolescents and young adults in the DONALD cohort study

Journal of Nutrition, Journal Year: 2024, Volume and Issue: 154(11), P. 3255 - 3265

Published: Sept. 25, 2024

High consumption of ultraprocessed foods (UPFs) continues to draw significant public health interest because the associated negative outcomes. Metabolomics can contribute understanding biological mechanisms through which UPFs may influence health.

Language: Английский

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Ultra-processed Food Intake During Pregnancy and its Impact on Maternal Diet Quality and Weight Change: A Systematic Review of Observational Studies

Current Nutrition Reports, Journal Year: 2024, Volume and Issue: 13(4), P. 800 - 814

Published: Oct. 7, 2024

Language: Английский

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Review of the Relationships Between Human Gut Microbiome, Diet, and Obesity

Nutrients, Journal Year: 2024, Volume and Issue: 16(23), P. 3996 - 3996

Published: Nov. 22, 2024

Obesity is a complex disease that increases the risk of other pathologies. Its prevention and long-term weight loss maintenance are problematic. Gut microbiome considered potential obesity modulator. The objective present study was to summarize recent findings regarding relationships between obesity, gut microbiota, diet (vegetable/animal proteins, high-fat diets, restriction carbohydrates), with an emphasis on dietary fiber resistant starch. composition human methods its quantification described. Products metabolism, such as short-chain fatty acids secondary bile acids, their effects intestinal barrier function immune homeostasis discussed in context obesity. importance starch emphasized far host concerned. finally summarized.

Language: Английский

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Quantitative Assessment of the Inadequate Intake of Macronutrients, Minerals, and Vitamins Associated with Ultra-Processed Food Consumption

International Journal of Environmental Research and Public Health, Journal Year: 2024, Volume and Issue: 21(7), P. 888 - 888

Published: July 8, 2024

Studies indicate that ultra-processed food (UP) consumption correlates negatively with essential vitamin and mineral intake positively sodium lipid intake. The objective of this study was to explore the relationship between UP deviations from nutritional guidelines. An observational, cross-sectional analytical conducted on a probability sample manufacturing workers in state Rio Grande do Norte, Brazil. Food assessed 24 h recall survey, nutrient inadequacies were calculated as difference individuals’ energy, macronutrients, minerals vitamins, dietary reference intakes for individuals same sex age group, then analyzed trends across percentage contribution total energy nonparametric multiple regression adjusted covariates. included 921 33 industries, 55.9% male, mean 32 years. Overall, population exhibited deficits all some micronutrients. With increasing intake, there is trend towards greater (p < 0.001), total, saturated, monounsaturated, trans fats n6-polyunsaturated fatty acids = 0.03), carbohydrates calcium 0.008), manganese thiamin B6 0.01); however, comes negative consequence terms reducing protein 0.037), fiber 0.035), copper 0.033), E 0.002) results show correcting micronutrient deficiencies by can also lead decrease diet quality.

Language: Английский

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Availability, Price and Nutritional Assessment of Plant-Based Meat Alternatives in Hypermarkets and Supermarkets in Petaling, the Most Populated District in Malaysia

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 16, 2024

Abstract This study investigated the availability, price, nutritional composition, and quality of PBMAs in supermarkets hypermarkets Petaling, most populated district Malaysia. The survey covered 85 stores through on-site visits, identifying 251 unique PBMA products from 42 brands. were categorized into nine groups: Burgers/Patties, Coated Meat, Luncheon Minced Pastries, Pieces/Chunks/Fillets/Strips, Prepacked Cooked Meals, Sausages, Seafood Balls/Cakes/Meatballs. indicated widespread availability with premium offering extensive selection. median prices across categories below MYR 7 (∼USD 1.6) per 100 grams, Pieces/Chunks/Fillets/Strips being affordable. Nutritionally, exhibited lower energy, total fat, saturated sodium, protein levels than meat equivalents, while showing higher carbohydrate content. Nutri-Score profiling revealed generally favourable scores (Grade A to C), indicating moderate good quality. These findings suggest that offer a viable alternative for consumers Malaysia seeking healthier more sustainable food options, particularly those aiming reduce their intake fat sodium. However, may not be recommended individuals diet. Further research is explore micronutrient profiles enhance dietary decision-making.

Language: Английский

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