Weight Reduction with GLP-1 Agonists and Paths for Discontinuation While Maintaining Weight Loss

Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 408 - 408

Published: March 13, 2025

Worldwide, nearly 40% of adults are overweight and 13% obese. Health consequences excess weight include cardiovascular diseases, type 2 diabetes, dyslipidemia, increased mortality. Treating obesity is challenging calorie restriction often leads to rebound gain. Treatments such as bariatric surgery create hesitancy among patients due their invasiveness. GLP-1 medications have revolutionized loss can reduce body in obese by between 15% 25% on average after about 1 year. Their mode action mimic the endogenous GLP-1, an intestinal hormone that regulates glucose metabolism satiety. However, drugs carry known risks and, since use for recent, may unforeseen well. They a boxed warning people with personal or family history medullary thyroid carcinoma multiple endocrine neoplasia syndrome 2. Gastrointestinal adverse events (nausea, vomiting, diarrhea) fairly common while pancreatitis obstruction rarer. There be lean mass well premature facial aging. A significant disadvantage using these high rate regain when they discontinued. Achieving success pharmacologic treatment then weaning avoid future negative effects would ideal.

Language: Английский

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Demographic and lifestyle factors affecting BMI and weight satisfaction of physicians in Babylon Province

Polish Annals of Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 6

Published: Jan. 10, 2025

Introduction Obesity, defined by a high body mass index (BMI), is significant global health issue that has increased over recent decades, leading to higher rates of type 2 diabetes, heart diseases, and some cancers. Aim To explore the demographic, socioeconomic, lifestyle factors affecting obesity in medical professionals, identify causes, create effective weight control strategies. Material methods A cross-sectional study 200 physicians utilized face-to-face interviews standardized questionnaire gather data on demographics, lifestyle, management, with BMI assessed according WHO guidelines. Results discussion In Babylon, troubling 75.5% are overweight or obese, highest among women aged 46, likely due menopause. Additionally, 78% those who do not exercise regularly have elevated levels. Factors like job stress ineffective management exacerbate obesity, particularly private clinic physicians. Notably, 56.5% physician’s express dissatisfaction their weight, especially categories. Conclusions reveals strong correlation between age female physicians, soaring 59.1% 46 older, primarily Overall, fall into obese categories, middle-aged individuals. Key influencing include insufficient failed loss efforts. Furthermore, there notable inverse relationship individuals compared normal weight.

Language: Английский

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Effects of antidepressants on body weight in patients treated in a naturalistic setting in Oman

Middle East Current Psychiatry, Journal Year: 2025, Volume and Issue: 32(1)

Published: Jan. 14, 2025

Abstract Background The rising use of antidepressants is critical for managing mental health disorders, but weight gain a concerning side effect, particularly with certain classes like TCAs and SSRIs. This study aims to investigate changes in Omani patients prescribed paroxetine, fluoxetine, mirtazapine, or venlafaxine. Method A cross-sectional conducted from January June 2023 at Sultan Qaboos University Hospital recruited adults disorders on these medications. Weight measurements were taken baseline follow-up, clinically significant defined as ≥ 7% increase. Results total 135 participants analyzed, showing mean 5.54 kg, 60.7% experiencing gain. Mirtazapine paroxetine exhibited the highest average increases (7.51 kg 8.05 respectively) compared fluoxetine (0.69 kg) venlafaxine (4.32 kg). No demographic factors influenced ( p = 0.213). Conclusion highlights among antidepressants, mirtazapine paroxetine. underscores importance monitoring clinical practice necessitates further investigations into individualized treatment strategies manage both weight-related concerns.

Language: Английский

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Configural path of obesity: linkage of physical activity and lifestyle based on fuzzy-set qualitative comparative analysis

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: March 28, 2025

Obesity plays a significant role in the burden of various health conditions, it is not only global issue but challenges national public system. Some regions China still face high prevalence obesity, and broadly recognized that physical activities interact with lifestyle different pathways would affect obesity. We aim to capture configurational paths lead using fuzzy set Qualitative Comparative Analysis. Eight obesity-related variables were involved, data collected between January 1, 2021, 31, 2022. The study shows six result which necessary condition "educational status," core conditions "the time exercise" "weekly sitting time*sleeping less than 6 h*second hand smoking exposure on average 4-6 days per week *keep excising 4 times week* exercise intensity shortness breath, markedly increased heart rate, heavy sweating" play an important obesity outcome, solution exhibits acceptable consistency 0.50. 0.76, coverage 0.31. Besides factors play(s) development we have consider multiple activity cross-cutting effect This can offer better understanding mechanisms cause by identifying characterizing regional population, help develop effective protective measure for

Language: Английский

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Weight loss methods and risk of depression: Evidence from the NHANES 2005-2018 cohort

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Gewichtneutrale Ansätze zur Behandlung von Adipositas

Aktuelle Ernährungsmedizin, Journal Year: 2025, Volume and Issue: 50(02), P. 115 - 128

Published: April 1, 2025

In Deutschland sind 19% der Erwachsenen von Adipositas betroffen 1. Traditionelle Gewichtsreduktionsprogramme zur Behandlung bringen häufig nicht die gewünschten Erfolge bei Gewichtsreduktion. Es werden daher dringend alternative Behandlungsansätze benötigt, um Versorgung Personen mit zu verbessern. Bisherige Interventionen gewichtsneutralen Ansätzen zeigen vielversprechende Ergebnisse.

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