Polyunsaturated Fatty Acids and Human Health: A Key to Modern Nutritional Balance in Association with Polyphenolic Compounds from Food Sources

Foods, Journal Year: 2024, Volume and Issue: 14(1), P. 46 - 46

Published: Dec. 27, 2024

Polyunsaturated fatty acids (PUFAs) are vital dietary elements that play a significant role in human nutrition. They highly regarded for their positive contributions to overall health and well-being. Beyond the fact they provide substantial supply of energy body (a saturated fats can also perform), these unsaturated and, especially, essential ones involved cell membrane structure, blood pressure regulation, coagulation; participate proper functioning immune system assimilation fat-soluble vitamins; influence synthesis pro- anti-inflammatory substances; protect cardiovascular system. Modern diets like Western diet American rich found especially fast food products, sweets, processed foods, has led an increase prevalence metabolic diseases worldwide (obesity, type II diabetes, gout, disease). Nutritionists have drawn attention moderate consumption need intake detriment ones. This paper examines biochemical roles polyunsaturated fats, particularly acids, contrasts benefits with detrimental effects fat overconsumption. Furthermore, it highlights necessity shifts towards increased PUFA mitigate global burden diet-related issues. The co-occurrence PUFAs polyphenols plant-based foods sophistication nature’s design. These bioactive compounds not randomly distributed but present humans consumed together historically. From traditional Mediterranean, which pairs olive oil (PUFAs polyphenols) vegetables legumes, Asian cuisines combining sesame seeds turmeric, cultural practices long harnessed this natural synergy.

Language: Английский

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Therapeutic Potential of Olive Leaf Extracts: A Comprehensive Review

Applied Biosciences, Journal Year: 2024, Volume and Issue: 3(3), P. 392 - 425

Published: Sept. 22, 2024

The olive tree is currently cultivated worldwide, with higher incidence in Mediterranean Basin. Its climate highly favorable to the synthesis of phenolic compounds, stored leaves; their consumption has been linked a lower cancer and cardiovascular disorders for which research interest upon this feature increased last decade. This study aimed (i) review evidence about importance leaf extract (OLE) on human health physiological effect its major compounds; (ii) update state art studies conducted technological usage extract; (iii) report potential uses OLE pharmaceuticals, food production, cosmetics; (iv) prospect future clinical applications from diverse cultivars, especially metabolic inflammatory conditions such as polycystic ovary syndrome (PCOS). Overall, cultivars richer TPC, including TFC, αT, omega-3 omega-9, present main target supplementation alone or conjunction vitaminic due nutraceutical value disorders, chronic diseases, anti-aging treatments, whereas less water content might be useful substrates preservation. With regard prospects, it would great clarify specific mechanisms underlying beneficial effects neuro-immune design safer healthier nature-based medicine wide array costly prevalent metabolic-related syndromes, namely, PCOS.

Language: Английский

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The Impact of Long-chain Omega-3 polyunsaturated fatty acids (LCPUFA) Supplementation in Pregnant Women Towards the Intelligence Status of Early Childhood: Protocol for Systematic Review and Meta-Analysis (Preprint)

JMIR Research Protocols, Journal Year: 2025, Volume and Issue: 14, P. e60417 - e60417

Published: March 4, 2025

Background Long-chain omega-3 polyunsaturated fatty acids (LCPUFAs) are essential that protect cellular structures and provide energy, particularly for fetal growth development. The maternal supplementations of LCPUFA may affect the rate intelligence in early childhood Objective This systematic review aims to synthesize available evidence on impact supplementation during pregnancy toward development by analyzing outcomes specifying aspects such as neurodevelopment, social-emotional, language, attention, behavior, cognition, vision, hearing, motor skills. Methods We will only include randomized controlled trials pregnant women supplemented with interventions outcome measured is children’s intelligence. Based World Health Organization's definition childhood, we children aged 8 years or younger. Children’s can be indicated using several tools measuring their index, Irrelevant unavailable studies excluded. A search conducted 3 electronic databases, namely PubMed, Scopus, Cochrane relevant synonymous terms. Study screening selection authors based eligibility criteria. Upon encountering conflicting decisions, a discussion held reach consensus. process recorded PRISMA (Preferred Reporting Items Systematic Reviews Meta-Analyses) flowchart. included subjected bias quality assessment accordance Critical Appraisal Skills Programme (CASP) Grading Recommendations Assessment, Development, Evaluation (GRADE) tool trials. Results An initial was November 1, 2023, which returned 1998 screening. extracted data classified into groups subgroups according indicator study. Next, summarized tables evidence. Whenever possible, meta-analysis homogeneous statistical software RevMan (version 5.4; Collaboration). Studies significant heterogeneity discussed narratively. estimated published 2025. Conclusions systematically pool potential use improve status. also important addressing any existing knowledge gaps this topic. Finally, deeper understanding association between consumption aid policy makers, health care practitioners, mothers more informed evidence-based decisions. Trial Registration PROSPERO CRD42023463910; https://www.crd.york.ac.uk/PROSPERO/view/CRD42023463910 International Registered Report Identifier (IRRID) DERR1-10.2196/60417

Language: Английский

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Comparative Analysis of Omega-3, Omega-6, and Endocannabinoid Content of Human, Cattle, Goat, and Formula Milk

Foods, Journal Year: 2025, Volume and Issue: 14(10), P. 1786 - 1786

Published: May 17, 2025

Human milk is the primary source of infant nutrition, although breastfeeding rates are declining today, and human often replaced by animal milk-based formula. Infant formula intended to replicate composition milk, albeit significant differences remain in physiological responses feeding offspring. More research needed on other types, especially regarding their lipid content. A comparative analysis different samples was carried out this study. The amount omega-3 fatty acids, omega-6 endocannabinoids measured human, cattle, goat as well milk- cow formulas using chromatography coupled mass spectrometry. Significant between milks were observed case acid endocannabinoid content, with higher lower levels than formulas. Goat shares highest similarity terms analyzed species. However, our results indicate that examined bioactive species failed be milk-derived

Language: Английский

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A Complete Examination of Omega-3 Full of Fat Acids: Their Origin, Activities, Well Being Advantages

Journal of Science Innovations and Nature of Earth, Journal Year: 2025, Volume and Issue: 5(1), P. 05 - 08

Published: March 1, 2025

Both n-3 in addition n-6 full of fat acids, are vital aimed at human vigor and physiological function as well all domesticated species. A proper dose LNA (linolenic acid) is crucial, the greasy acid proportion ineffective hinders growing polyunsaturated fatty consumption. When ingested sufficient quantities while avoiding additional FA, it can convert to EPA DHA promoting optimal functions wellness. Humans have a lower turnover compared rodents, transformation less common significantly more restricted. Stearidonic skips crucial phase production eicosapentaenoic acid, rather than docosa-hexaenoic from linolenic acid. Genetically modified oil crops being developed improve stearidonic composition, supplementation has potential boost humans. quantitative extraction pets not yet been described. However, conversion restricted these areas, aquatic creatures may be affected. Research indicates that consuming fish particularly DHA, benefit health. This study examines health consequences throughout pregnancy breastfeeding, immune response stress, CVS illness, cancer, psychological disorders. Pregnant nursing women should ingest minimum 200 mg daily. Certain feed supplements profile animal-derived products, such for example essence eggs main dairy.

Language: Английский

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The Correlation between Knowledge of Food Sustainability, Sustainable Eating Attitudes, and Adherence to the Mediterranean Diet among Blue- and White-Collar Employees

Sustainability, Journal Year: 2024, Volume and Issue: 16(19), P. 8644 - 8644

Published: Oct. 6, 2024

To enhance and advance both human planetary health, it is imperative to transition towards more sustainable nutrition approaches. This study aimed assess the correlation between levels of sustainability knowledge, attitudes nutrition, adherence Mediterranean diet (MD) among blue- white-collar employees. included 210 adults, half whom were employees, with other being blue-collar Sociodemographic data collected, anthropometric measurements performed. The Questionnaire on Food Sustainability Knowledge Attitudes Sustainable Eating Diet Adherence Scale (MEDAS) also in applied survey. Dietary intake was assessed using 24 h dietary records. mean age 41.9 ± 10.87 years. Of participants, 56.2% classified as overweight or obese. level knowledge concept “food sustainability” all participants 30.5%. MEDAS score 5.4 1.90, 74.8% did not follow MD. Positive correlations found Definition (r = 0.174) (p ˂ 0.05) Attitude 0.312) 0.001). Negative body weight −0.320; p 0.001), BMI −0.249; waist circumference −0.278; PBF −0.177; 0.05). We that, increased, behaviors improved, MD incidence obesity decreased.

Language: Английский

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Global research dynamics in the Mediterranean diet and diabetes mellitus: a bibliometric study from 2014 to 2024

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 14, 2024

Objective The Mediterranean diet (MedDiet) has been found to have benefits for diabetes mellitus (DM), but a bibliometric analysis of its association with DM yet be conducted. This paper aims explore the current status and research hotspots on connection between from 2014 2024, providing reference future studies. Methods We retrieved articles published 2024 Web Science database analyzed them using R software, VOSviewer, CiteSpace. Results A total 2,806 were included in this study. Research relationship MedDiet showed steady increase publication volume 2019, followed by sharp rise 2020 2023. Spain was leading country terms volume, Italy, United States, China, Greece. also led international collaborations, CIBER—Centro de Investigación Biomédica en Red Harvard University being most prominent collaboration centers. Nutrients frequently cited journal field. Common keywords literature components such as olive oil, legumes, red wine. Mechanisms studied field primarily focused antioxidant effects, improvements insulin sensitivity secretion, regulation lipid metabolism, modulation gut microbiota. Conclusion beneficial effects patients garnered significant attention researchers worldwide, it is expected become major focus prevention treatment. study provides comprehensive regarding DM, offering valuable references research.

Language: Английский

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The relationship of dietary omega-3 fatty acid and omega-6 to omega-3 ratio intake and likelihood of type 2 diabetes in a cross-sectional study

BMC Endocrine Disorders, Journal Year: 2024, Volume and Issue: 24(1)

Published: Nov. 29, 2024

There is a belief that consuming significant amount of omega-3 and omega-6 fatty acids can positively affect chronic diseases. However, the connection between these type 2 diabetes mellitus (T2DM) risk remains unclear. To explore this further, we conducted study to investigate relationship dietary intake (FA), as well ratio, odds T2DM. Our research involved cross-sectional analysis data from Ravansar Non-Communicable Disease (RaNCD) cohort. We evaluated their habits using comprehensive 118-item food frequency questionnaire (FFQ). determine aforementioned association, employed logistic regression calculate ratios (OR) 95% confidence intervals (CIs). The prevalence T2DM among 8744 qualified participants was 751 (8.6%). After considering all possible factors could outcome, high associated with 58% lower likelihood (OR: 0.42; CI: 0.32, 0.56; P-trend: <0.001). In contrast, at fourth quartile omega 6 3 FA ratio had higher odd 1.42; 95%CI: 1.11, 1.84; 0.01). Nevertheless, there no highest lowest 0.91; 0.71, 1.17; 0.80). According study, through diet linked diabetes. Conversely, an elevated greater

Language: Английский

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Dietary Intake of Polyunsaturated Fatty Acids Is Associated with Blood Glucose and Diabetes in Community-Dwelling Older Adults

Nutrients, Journal Year: 2024, Volume and Issue: 16(23), P. 4087 - 4087

Published: Nov. 27, 2024

Objectives: The present study was conducted to examine the cross-sectional associations between dietary intake of polyunsaturated fatty acids (PUFAs) and cardiometabolic risk factors in a large sample Italian community-dwelling older adults. Methods: This is study. Longevity Check-up 8+ (Lookup 8+) an ongoing project that started June 2015. unconventional settings (e.g., exhibitions, malls, health promotion campaigns) across Italy with aim fostering adoption healthy lifestyles general population. For study, participants were eligible if they 65+ years provided written informed consent. Systolic blood pressure (SBP) diastolic (DBP), glucose cholesterol levels assessed. A 12-item food frequency questionary used estimate PUFAs, which included omega-3 (α-linolenic acid [ALA], eicosapentaenoic [EPA], docosahexaenoic [DHA]) omega-6 acids. Results: Data 4461 adults (♀56%, mean age: 72.9 years, body mass index [BMI]: 26.1 kg/m2, glucose: 109 mg/dL, total cholesterol: 198.5 ALA: 8.8%, EPA: 16.0%, DHA: 26.1%) cross-sectionally analyzed. Multilinear regression results indicated high consumption EPA, DHA, DHA+EPA negatively significantly associated levels. Furthermore, binary analysis ALA PUFAs inversely prevalence diabetes. In contrast, BMI values positively EPA DHA+EPA. Conclusions: Findings indicate cross-sectionally, inversely, diabetes

Language: Английский

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The Role of Omega-3 Polyunsaturated Fatty Acids in Patients with Metabolic Syndrome and Endothelial Dysfunction

Medicina, Journal Year: 2024, Volume and Issue: 61(1), P. 43 - 43

Published: Dec. 30, 2024

Background and Objectives: Metabolic syndrome (MS) represents several diseases encompassing a heterogeneous group of biochemical physiological abnormalities characterized by structural functional alterations in the myocardium, including endothelium coronary arteries. MS also affects substantial portion global population. Understanding risk factors, development treatment associated with are paramount importance for early identification, prevention. This study was designed to evaluate role supplementation omega-3 polyunsaturated fatty acids (n-3 PUFAs) on endothelial function patients MS. Materials Methods: A total 80 were enrolled two groups. The evaluated (EF) subjects before after three-month n-3 PUFAs dose 2.4 g daily (800 mg, three times day) vs. placebo, using an Endo-PAT2000 device (Itamar Medical Ltd., Caesarea, Israel) measuring reactive hyperemia index (a parameter EF) augmentation arterial stiffness). Plasmatic levels glutathione peroxidase, homocysteine, apolipoprotein B lipoprotein comparison. Results: results showed that average value 1.62 ± 0.42, compared 1.96 0.62 at end (p < 0.005). changed from 14.66 19.55 9.21 15.64 = 0.003) PUFA. revealed statistically significant decrease (0.94 0.36 1.13 0.35, p 0.001) homocysteine (19.31 5.29 13.78 3.05, increase peroxidase plasma (41.65 8.90 45.20 8.01), 0.001. Conclusions: this prospective improvement EF treated daily.

Language: Английский

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