Obesity and Its Related Diseases: A New Escalating Alarming in Global Health

Journal of Innovations in Medical Research, Journal Year: 2023, Volume and Issue: 2(3), P. 12 - 23

Published: March 1, 2023

At present rising of obesity becomes a principal public global health and economic concern. In 1997, the World Health Organization (WHO) has declared as epidemic. About one-third world population is now suffering from overweight or obesity. It estimated that some diseases, such hypertension, cardiovascular Alzheimer disease, asthma, metabolic syndrome, liver steatosis, gallbladder osteoarthritis, obstructive sleep apnea, certain types cancer, hypercholesterolemia, musculoskeletal disorders (joint muscle pains), type 2 diabetes are increased globally due to Obesity can affect nearly every organ system human body even may cause total heart failure. On other hand, incurring substantial costs for healthcare already affected society. be prevented, avoided, cured. Prevention best policy, but proper treatment necessary who with This article tries discuss aspects obesity, causes prevention

Language: Английский

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Ulvophyte Green Algae Caulerpa lentillifera: Metabolites Profile and Antioxidant, Anticancer, Anti-Obesity, and In Vitro Cytotoxicity Properties

Molecules, Journal Year: 2023, Volume and Issue: 28(3), P. 1365 - 1365

Published: Jan. 31, 2023

Marine algae have excellent bioresource properties with potential nutritional and bioactive therapeutic benefits, but studies regarding Caulerpa lentillifera are limited. This study aims to explore the metabolites profile antioxidant, anticancer, anti-obesity, in vitro cytotoxicity of fractionated ethanolic extract C. using two maceration soxhlet extraction methods. Dried simplicia was mashed extracted ethanol solvent, concentrated evaporated, then sequentially partitioned equal volumes ethyl acetate n-Hexane. Six samples were used this study, consisting ME (Maceration-Ethanol), MEA (Maceration-Ethyl Acetate), MH (Maceration-n-Hexane), SE (Soxhletation-Ethanol), SEA (Soxhletation-Ethyl SH (Soxhletation-n-Hexane). Non-targeted metabolomic profiling determined LC-HRMS, while anticancer DPPH ABTS, lipase inhibition, MTT assay, respectively. demonstrates that has several functional metabolites, antioxidant capacity (EC50 is very close EC50 Trolox), as well anti-obesity < orlistat, an inhibitor lipid hydrolyzing enzymes), which useful precursors for new approaches improving obesity-related diseases. More interestingly, ME, MH, novel agents drugs, especially hepatoma, breast, colorectal, leukemia cancers. Finally, can be a nutraceutical great benefits.

Language: Английский

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Human gut microbiome, diet, and mental disorders

International Microbiology, Journal Year: 2024, Volume and Issue: unknown

Published: April 1, 2024

Abstract Diet is one of the most important external factor shaping composition and metabolic activities gut microbiome. The microbiome plays a crucial role in host health, including immune system development, nutrients metabolism, synthesis bioactive molecules. In addition, has been described as critical for development several mental disorders. Nutritional psychiatry an emerging field research that may provide link between diet, microbial function, brain health. this study, we have reviewed influence different diet types, such Western, Mediterranean, vegetarian, ketogenic, on microbiota their implication various neuropsychiatric psychological

Language: Английский

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Sex-differences in Mediterranean diet: a key piece to explain sex-related cardiovascular risk in obesity? A cross-sectional study

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Jan. 10, 2024

Abstract Background Mediterranean Diet (MD) has many health benefits, particularly in reducing cardiovascular risk (CVR). However, it is still little known if there are any sex differences following this nutritional pattern and, thus, the potential sex-related repercussions on CVR obesity. The study aimed to characterize adherence MD and its association with factors subjects Methods A total of 968 females (33.81 ± 11.06 years; BMI 34.14 7.43 kg/m 2 ) 680 males (aged 34.77 11.31years; 33.77 8.13 were included a cross-sectional observational study. Lifestyle habits, anthropometric parameters, high sensitivity C-reactive protein (hs-CRP), evaluated. Results Females had significantly higher lower hs-CRP levels than (p < 0.001). Additionally, consumed more vegetables, fruits, legumes, fish/seafood, nuts, sofrito sauce less quantity olive oil, butter, cream, margarine, red/processed meats, soda drinks = 0.001), red wine, commercial sweets confectionery their counterparts. PREDIMED score ≤ 6 was associated increased both sexes. Conclusions MD, CVR, different food preferences males. Although same threshold been identified as spy preference individual foods could explain impact Graphical

Language: Английский

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Nutritional Strategies for Battling Obesity-Linked Liver Disease: the Role of Medical Nutritional Therapy in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Management

Current Obesity Reports, Journal Year: 2025, Volume and Issue: 14(1)

Published: Jan. 11, 2025

This narrative review explores the role of Medical Nutritional Therapy (MNT) in managing Metabolic-Associated Steatotic Liver Disease (MASLD), previously known as nonalcoholic fatty liver disease. It aims to examine effectiveness specific nutritional strategies preventing and treating this obesity-linked Emerging evidence underscores benefits Mediterranean diet, low-carbohydrate diets, intermittent fasting reducing fat, improving insulin sensitivity, mitigating inflammation. Supplementing with vitamin E, omega-3 acids, silymarin can potentially reduce fibrosis promote health. MNT is a key intervention for MASLD management, emphasizing dietary patterns, caloric restriction, nutraceutical supplementation. Integrating these lifestyle modifications, including regular physical activity, offers comprehensive approach metabolic outcomes patients MASLD. Further research needed refine personalize therapeutic interventions.

Language: Английский

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Long-Term Efficacy and Safety of Nutritional and Pharmacological Strategies for Obesity

Current Obesity Reports, Journal Year: 2025, Volume and Issue: 14(1)

Published: Jan. 3, 2025

Language: Английский

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Unlocking the potential: very-low-energy ketogenic therapy in obesity-related disorders

Food and Agricultural Immunology, Journal Year: 2025, Volume and Issue: 36(1)

Published: Jan. 16, 2025

The Very Low-Energy Ketogenic Therapy (VLEKT) is a structured, multi-phase dietary regimen characterized by carbohydrate intake of less than 50 g/day and daily caloric fewer 800 kcal, which induces ketosis facilitates significant weight loss. Evidence suggests that this nutritional therapy can improve glycemic control, lipid profiles, blood pressure, making it promising option for managing type 2 diabetes (T2D) reducing cardiovascular risk. These benefits are achieved through reductions in triglycerides low-density lipoprotein cholesterol (LDL-c), alongside increases high-density (HDL-c). However, the effects VLEKT on metabolism remain controversial. review emphasizes urgent need further research to validate long-term safety efficacy VLEKT. It also highlights critical role personalized plans, supervised healthcare professionals, optimize health outcomes address individual patient needs.

Language: Английский

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Ketogenic Diet as Medical Prescription in Women with Polycystic Ovary Syndrome (PCOS)

Current Nutrition Reports, Journal Year: 2023, Volume and Issue: 12(1), P. 56 - 64

Published: Jan. 25, 2023

Abstract Purpose of Review The polycystic ovary syndrome (PCOS) is an endocrine dysfunction associated with a myriad metabolic disorders and high rate infertility. In order to aid its management, several lifestyle/dietary interventions have been evaluated. Very low-calorie ketogenic diet (VLCKD) rapidly showing promising benefits not only in obesity but also the treatment other diseases. main objective this review assess scientific evidence support dietary pattern as effective measure for treating PCOS it. Recent Findings Preliminary data suggested significant improvements body weight composition, profile (glucose, serum insulin, triglycerides, total low-density lipoprotein cholesterol), insulin resistance following VLCKD. However, still scarce needs be more substantiated. Summary Weight reduction women has shown improve derangements there no consensus on ideal or macronutrient composition. There some supporting possible role Mediterranean improving infertility (along well-known benefits) PCOS. Of note, VLCKD might considered potential intervention short-term PCOS, it must prescribed carefully guided by professionals.

Language: Английский

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Pathogenesis of Hypertension in Metabolic Syndrome: The Role of Fructose and Salt

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(5), P. 4294 - 4294

Published: Feb. 21, 2023

Metabolic syndrome is manifested by visceral obesity, hypertension, glucose intolerance, hyperinsulinism, and dyslipidemia. According to the CDC, metabolic in US has increased drastically since 1960s leading chronic diseases rising healthcare costs. Hypertension a key component of associated with an increase morbidity mortality due stroke, cardiovascular ailments, kidney disease. The pathogenesis hypertension syndrome, however, remains poorly understood. results primarily from caloric intake decreased physical activity. Epidemiologic studies show that enhanced consumption sugars, form fructose sucrose, correlates amplified prevalence syndrome. Diets high fat content, conjunction elevated salt intake, accelerate development This review article discusses latest literature specific emphasis on role its stimulatory effect absorption small intestine tubules.

Language: Английский

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Mediterranean diet and olive oil, microbiota, and obesity-related cancers. From mechanisms to prevention

Seminars in Cancer Biology, Journal Year: 2023, Volume and Issue: 95, P. 103 - 119

Published: Aug. 4, 2023

Olive oil (OO) is the main source of added fat in Mediterranean diet (MD). It a mix bioactive compounds, including monounsaturated fatty acids, phytosterols, simple phenols, secoiridoids, flavonoids, and terpenoids. There growing body evidence that MD OO improve obesity-related factors. In addition, obesity has been associated with an increased risk for several cancers: endometrial, oesophageal adenocarcinoma, renal, pancreatic, hepatocellular, gastric cardia, meningioma, multiple myeloma, colorectal, postmenopausal breast, ovarian, gallbladder, thyroid cancer. However, epidemiological linking these cancers, their potential mechanisms action, especially those involving gut microbiota, are not clearly described or understood. The goals this review 1) to update current knowledge on associations between consumption 2) identify microbiota involved 3) report effects mechanisms.

Language: Английский

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