Inter-organ metabolic interaction networks in non-alcoholic fatty liver disease

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 9, 2025

Non-alcoholic fatty liver disease (NAFLD) is a multisystem metabolic disorder, marked by abnormal lipid accumulation and intricate inter-organ interactions, which contribute to systemic imbalances. NAFLD may progress through several stages, including simple steatosis (NAFL), non-alcoholic steatohepatitis (NASH), cirrhosis, potentially cancer. This closely associated with disorders driven overnutrition, key pathological processes dysregulation, impaired autophagy, mitochondrial dysfunction, endoplasmic reticulum (ER) stress, local inflammation. While hepatic metabolism in well-documented, further research into communication mechanisms crucial for deeper understanding of progression. review delves intrahepatic networks tissue-specific signaling mediators involved pathogenesis, emphasizing their impact on distal organs.

Language: Английский

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Liver function linked to bone health: A bibliometric of the liver-bone axis

World Journal of Hepatology, Journal Year: 2025, Volume and Issue: 17(2)

Published: Feb. 20, 2025

BACKGROUND The liver exerts profound influence on skeletal health, while osseous tissues reciprocally modulate hepatic function. This bidirectional metabolic axis between these two organ systems plays a pivotal role in both physiological homeostasis and pathological states. AIM To investigate analyze the literatures liver-bone using bibliometrics. METHODS A comprehensive literature search pertaining to was conducted Science Citation Index Expanded within Web of Core Collection. Subsequently, visualization bibliometric analyses were performed utilizing VOSviewer (version 1.6.20), Citespace 6.2.R4), R programming language. RESULTS analysis encompasses 855 publications, comprising 694 articles 161 reviews, authored by 4988 researchers from 425 institutions across 61 countries. United States China emerge as leading nations terms publication volume. University California system stands out most influential institution research. Guanabens N is identified prolific author this field. annual increase publications related underscores its growing prominence research focus. study highlights key areas investigation, including osteoporosis, bone metabolism, non-alcoholic fatty disease, insulin-like growth factor-1, which represent current prospective hot topics domain. CONCLUSION investigation employs methodologies conduct systematic spanning 2001 2024. exponential over past decades significance synthesizing outcomes Through rigorous statistical analyses, we delineate fundamental contributions field providing strategic direction for emerging scholars. Furthermore, illuminate trajectories identify promising future investigative directions. Investigation enhances our comprehension inter-organ communication networks. Conceptualizing organs an integrated provides insights into pathophysiological mechanisms disease management strategies. paradigm not only facilitates development sophisticated diagnostic modalities but also catalyzes discovery novel therapeutic agents targeting mechanistic pathways, thereby advancing capacity diagnose treat disorders.

Language: Английский

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Unraveling the link between metabolic dysfunction-associated steatotic liver disease and osteoporosis: a bridging function of gut microbiota

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: April 1, 2025

This review examines the strong association between metabolic dysfunction-associated steatotic liver disease (MASLD) and osteoporosis (OP), with a particular focus on role of gut microbiota in linking these two disorders. Both MASLD OP are closely linked to syndrome, their pathogenesis involves multiple factors, such as inflammatory response, insulin resistance, altered intestinal permeability, estrogen deficiency. Dysregulation not only affects hepatic fat accumulation bone metabolism disorders through metabolites, short-chain fatty acids, but also exacerbates systemic chronic inflammation by impairing barrier function, thus accelerating progression both diseases. article summarizes recent studies that highlight central co-morbid factor OP, offering new perspectives for future diagnostic therapeutic strategies.

Language: Английский

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Osteocalcin: A bone protein with multiple endocrine functions

Clinica Chimica Acta, Journal Year: 2024, Volume and Issue: 567, P. 120067 - 120067

Published: Dec. 2, 2024

Language: Английский

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