International Journal of Oral Science,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: Oct. 31, 2024
Abstract
The
reconstruction
of
craniomaxillofacial
bone
defects
remains
clinically
challenging.
To
date,
autogenous
grafts
are
considered
the
gold
standard
but
present
critical
drawbacks.
These
shortcomings
have
driven
recent
research
on
to
focus
synthetic
with
distinct
materials
and
fabrication
techniques.
Among
various
methods,
additive
manufacturing
(AM)
has
shown
significant
clinical
potential.
AM
technologies
build
three-dimensional
(3D)
objects
personalized
geometry
customizable
from
a
computer-aided
design.
layer-by-layer
3D
biomaterial
structures
can
support
formation
by
guiding
cell
migration/proliferation,
osteogenesis,
angiogenesis.
Additionally,
these
be
engineered
degrade
concomitantly
new
tissue
formation,
making
them
ideal
as
grafts.
This
review
delves
into
key
advances
bioceramic
grafts/scaffolds
obtained
printing
for
reconstruction.
In
this
regard,
relevant
topics
such
ceramic-based
biomaterials,
graft/scaffold
characteristics
(macro/micro-features),
material
extrusion-based
printing,
step-by-step
workflow
engineer
discussed.
Importantly,
in
vitro
models
highlighted
conjunction
thorough
examination
signaling
pathways
reported
when
investigating
bioceramics
their
effect
cellular
response/behavior.
Lastly,
we
summarize
potential
translation
opportunities
regeneration.
Advanced Functional Materials,
Journal Year:
2021,
Volume and Issue:
31(21)
Published: March 8, 2021
Abstract
Bone
tissue
engineering
(BTE)
is
a
rapidly
growing
field
aiming
to
create
biofunctional
that
can
integrate
and
degrade
in
vivo
treat
diseased
or
damaged
tissue.
It
has
become
evident
scaffold
fabrication
techniques
are
very
important
dictating
the
final
structural,
mechanical
properties,
biological
response
of
implanted
biomaterials.
A
comprehensive
review
current
accomplishments
on
techniques,
their
structure,
function
properties
for
BTE
provided
herein.
Different
types
biomaterials
ranging
from
inorganic
natural
synthetic
polymers
related
composites
processing
presented.
Emergent
scaffolding
such
as
electrospinning,
freeze‐drying,
bioprinting,
decellularization
also
discussed.
Strategies
improve
vascularization
potential
immunomodulation,
which
considered
grand
challenge
scaffolding,
Journal of Magnesium and Alloys,
Journal Year:
2022,
Volume and Issue:
10(6), P. 1428 - 1456
Published: May 2, 2022
Traditional
orthopedic
metal
implants,
such
as
titanium
(Ti),
Ti
alloys,
and
cobalt-chromium
(Co-Cr)
cannot
be
degraded
in
vivo.
Fracture
patients
is
must
always
suffer
a
second
operation
to
remove
the
implants.
Moreover,
stress
shielding,
or
protection
occurs
when
traditional
implants
are
applied
fractures
surgery.
The
mechanical
shunt
produced
by
can
cause
bone
loss
over
time,
resulting
decreased
strength
delayed
fracture
healing.
Biodegradable
metals
that
'biocorrode'
currently
attracting
significant
interest
orthopedics
field
due
their
suitability
temporary
As
one
of
biodegradable
metals,
magnesium
(Mg)
Mg
alloys
have
gained
medicine
low
density,
excellent
biocompatibility,
high
bioresorbability,
proper
properties.
Additionally,
ions
released
from
promote
osteogenesis
angiogenesis
during
degradation
process
vivo,
which
substantially
better
for
fixation
than
other
bioinert
materials.
Therefore,
this
review
focuses
on
properties,
fabrication,
biological
functions,
surface
modification
Mg-based
novel
bioabsorbable
biomaterials
applications.
Bioactive Materials,
Journal Year:
2022,
Volume and Issue:
16, P. 271 - 284
Published: Feb. 28, 2022
Angiogenesis
and
neurogenesis
play
irreplaceable
roles
in
bone
repair.
Although
biomaterial
implantation
that
mimics
native
skeletal
tissue
is
extensively
studied,
the
nerve-vascular
network
reconstruction
neglected
design
of
biomaterials.
Our
goal
here
to
establish
a
periosteum-simulating
bilayer
hydrogel
explore
efficiency
repair
via
enhancement
angiogenesis
neurogenesis.
In
this
contribution,
we
designed
platform
incorporated
with
magnesium-ion-modified
black
phosphorus
(BP)
nanosheets
for
promoting
neuro-vascularized
regeneration.
Specifically,
(BP@Mg)
into
gelatin
methacryloyl
(GelMA)
prepare
upper
hydrogel,
whereas
bottom
was
as
double-network
system,
consisting
two
interpenetrating
polymer
networks
composed
GelMA,
PEGDA,
β-TCP
nanocrystals.
The
magnesium
ion
modification
process
developed
enhance
BP
nanosheet
stability
provide
sustained
release
bioactive
ions.
results
demonstrated
layer
provided
bionic
periosteal
structure,
which
significantly
facilitated
induction
endothelial
cell
migration
presented
multiple
advantages
upregulation
nerve-related
protein
expression
neural
stem
cells
(NSCs).
Moreover,
promoted
marrow
mesenchymal
(BMSCs)
activity
osteogenic
differentiation.
We
next
employed
structure
correct
rat
skull
defects.
Based
on
our
radiological
histological
examinations,
scaffolds
markedly
enhanced
early
vascularization
neurogenesis,
prompted
eventual
regeneration
remodeling.
current
strategy
paves
way
designing
biomaterials
ACS Biomaterials Science & Engineering,
Journal Year:
2022,
Volume and Issue:
8(6), P. 2321 - 2335
Published: May 31, 2022
Large-sized
bone
defects
are
a
great
challenge
in
clinics
and
considerably
impair
the
quality
of
patients'
daily
life.
Tissue
engineering
strategies
using
cells,
scaffolds,
bioactive
molecules
to
regulate
microenvironment
regeneration
is
promising
approach.
Zinc,
magnesium,
iron
ions
natural
elements
tissue
participate
many
physiological
processes
metabolism
therefore
have
potential
for
regeneration.
In
this
review,
we
performed
systematic
analysis
on
effects
zinc,
engineering.
We
focus
role
these
properties
scaffolds
(mechanical
strength,
degradation,
osteogenesis,
antibacterial
properties,
etc.).
hope
that
our
summary
current
research
achievements
notifications
improve
repair
will
find
new
inspiration
breakthroughs
inspire
future
research.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: Nov. 12, 2024
Scaffold
porosity
is
a
critical
factor
in
replicating
the
complex
vivo
microenvironment,
directly
influencing
cellular
interactions,
migration,
nutrient
transfer,
vascularization,
and
formation
of
functional
tissues.
For
optimal
tissue
formation,
scaffold
design
must
account
for
various
parameters,
including
material
composition,
morphology,
mechanical
properties,
compatibility.
This
review
highlights
importance
interconnected
pore
size,
emphasizing
their
impact
on
behavior
across
several
engineering
domains,
such
as
skin,
bone,
cardiovascular,
lung
Specific
size
ranges
enhance
functionality
different
tissues:
small
pores
(∼1–2
µm)
aid
epidermal
cell
attachment
skin
regeneration,
moderate
(∼2–12
support
dermal
larger
(∼40–100
facilitate
vascular
structures.
bone
engineering,
multi-layered
scaffolds
with
smaller
(50–100
foster
attachment,
while
(200–400
diffusion
angiogenesis.
Cardiovascular
tissues
benefit
from
sizes
(∼25–60
to
balance
integration
diffusion.
By
addressing
challenges
optimizing
distributions,
this
provides
insights
into
innovations,
ultimately
advancing
regeneration
strategies.
Aggregate,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 9, 2025
ABSTRACT
The
repair
and
functional
reconstruction
of
bone
defects
resulting
from
trauma,
surgical
resection,
degenerative
diseases,
congenital
malformations
are
major
clinical
challenges.
Bone
tissue
engineering
has
significant
advantages
in
the
treatment
severe
defects.
Vascularized
scaffolds
gradually
attracting
attention
development
because
their
excellent
biomimetic
properties
efficient
efficiency.
Three‐dimensional
(3D)
printing
technology,
which
can
be
used
to
fabricate
structures
at
different
scales
using
a
wide
range
materials,
been
production
vascularized
scaffolds.
This
review
discusses
research
progress
3D
for
Angiogenesis‐osteogenesis
coupling
regeneration
process
is
first
introduced,
followed
by
summary
technologies,
inks,
bioactive
factors
Notably,
this
focuses
on
structural
design
strategies
Finally,
application
medicine,
as
well
challenges
outlooks
future
development,
described.
Biomedical Materials,
Journal Year:
2021,
Volume and Issue:
16(4), P. 045013 - 045013
Published: March 24, 2021
Abstract
There
is
a
need
for
effective
wound
healing
through
rapid
closure,
reduction
of
scar
formation,
and
acceleration
angiogenesis.
Hydrogel
widely
used
in
tissue
engineering,
but
it
not
an
ideal
solution
because
its
low
vascularization
capability
poor
mechanical
properties.
In
this
study,
gelatin
methacrylate
(GelMA)
was
tested
as
viable
option
with
tunable
physical
GelMA
hydrogel
incorporating
vascular
endothelial
growth
factor
(VEGF)
mimicking
peptide
successfully
printed
using
three-dimensional
(3D)
bio-printer
owing
to
the
shear-thinning
properties
inks.
The
3D
structure
patch
had
high
porosity
water
absorption
Furthermore,
bioactive
characterization
confirmed
by
cell
culture
mouse
fibroblasts
lines
(NIH
3T3)
human
umbilical
vein
cells.
VEGF
peptide,
which
slowly
released
from
patches,
can
promote
viability,
proliferation,
tubular
formation.
addition,
pig
skin
model
evaluate
wound-healing
efficacy
GelMA-VEGF
patches;
results
suggest
that
be
dressing.
