A MgFe‐LDH Nanosheet‐Incorporated Smart Thermo‐Responsive Hydrogel with Controllable Growth Factor Releasing Capability for Bone Regeneration

Advanced Materials, Journal Year: 2022, Volume and Issue: 35(5)

Published: Nov. 25, 2022

Although growth factor (GF)-loaded hydrogels have been explored as promising materials in repairing bone defects, it still remains challenging to construct smart with excellent gelation/mechanical properties well controllable GF releasing capability. Herein, the incorporation of morphogenetic protein 2 (BMP-2)-functionalized MgFe-layered double hydroxide (LDH) nanosheets into chitosan/silk fibroin (CS) loaded platelet-derived factor-BB (PDGF-BB) a injectable thermo-responsive hydrogel (denoted CSP-LB), which can achieve burst release PDGF-BB and sustained BMP-2, for highly efficient regeneration is reported. The MgFe-LDH CS not only shortens gelation time decreases sol-gel transition temperature, but also enhances mechanical property hydrogel. Because sequential dual-GFs bioactive Mg2+ /Fe3+ ions, vitro experiments prove that CSP-LB exhibits angiogenic osteogenic compared In vivo further significantly enhance higher volume mineral density than This thermo-sensitive possesses capability properties, thus providing minimally invasive solution defect treatment.

Language: Английский

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3D bioprinting advanced biomaterials for craniofacial and dental tissue engineering – A review

Materials & Design, Journal Year: 2024, Volume and Issue: 241, P. 112886 - 112886

Published: March 28, 2024

The rising incidence of defects in oral and maxillofacial tissues, linked to factors such as trauma, tumors, periodontal disease, aging, poses significant challenges. Current treatments, involving autografts, allografts, synthetic graft materials, face obstacles like secondary inflammation, inadequate biocompatibility. Tissue engineering, integrating cell biology material science since the 1990s, relies heavily on biomaterial scaffolds promote adhesion, proliferation, differentiation. Traditional scaffold fabrication, including 3D printing, methods lack precision, hindering effective tissue repair by controlling distribution extracellular matrix. Biomedical engineering advancements have introduced bioprinting an innovative solution, overcoming constraints conventional scaffolds. technology enables rapid precise reconstruction damaged tissues with loaded cells, mimicking vivo environments. This paper explores key technologies inkjet-based, extrusion-based, fused deposition modeling, laser-assisted, VAT photopolymerization, freeform reversible embedding suspended hydrogels, sacrificial template printing. selection materials suitable mechanical biological properties is crucial, considering distinct requirements each technique. review provides a comprehensive survey research progress printing applications craniofacial dental serving valuable reference for future medical research.

Language: Английский

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A five-in-one novel MOF-modified injectable hydrogel with thermo-sensitive and adhesive properties for promoting alveolar bone repair in periodontitis: Antibacterial, hemostasis, immune reprogramming, pro-osteo-/angiogenesis and recruitment

Bioactive Materials, Journal Year: 2024, Volume and Issue: 41, P. 239 - 256

Published: July 24, 2024

Periodontitis is a chronic inflammatory disease caused by plaque that destroys the alveolar bone tissues, resulting in tooth loss. Poor eradication of pathogenic microorganisms, persistent malignant inflammation and impaired osteo-/angiogenesis are currently primary challenges to control progression rebuild damaged bone. However, existing treatments for periodontitis fail comprehensively address these issues. Herein, an injectable composite hydrogel (SFD/CS/ZIF-8@QCT) encapsulating quercetin-modified zeolitic imidazolate framework-8 (ZIF-8@QCT) developed. This possesses thermo-sensitive adhesive properties, which can provide excellent flowability post-injection stability, resist oral fluid washout as well achieve effective tissue adhesion. Inspirationally, it observed SFD/CS/ZIF-8@QCT exhibits rapid localized hemostatic effect following implantation, then virtue sustained release zinc ions quercetin exerts collective functions including antibacterial, immunomodulation, pro-osteo-/angiogenesis pro-recruitment, ultimately facilitating regeneration. Notably, our study also demonstrates inhibition PDLSCs under due strong energy metabolism powerful activation oxidative stress autophagy, whereas synergistic effects released reversing biological processes. Overall, presents innovative insights into advancement biomaterials regenerate periodontitis.

Language: Английский

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Bioadhesives and bioactive hydrogels for wound management

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 379, P. 285 - 302

Published: Jan. 13, 2025

Language: Английский

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Ion-Doped Calcium Phosphate-Based Coatings with Antibacterial Properties

Journal of Functional Biomaterials, Journal Year: 2023, Volume and Issue: 14(5), P. 250 - 250

Published: April 29, 2023

Ion-substituted calcium phosphate (CP) coatings have been extensively studied as promising materials for biomedical implants due to their ability enhance biocompatibility, osteoconductivity, and bone formation. This systematic review aims provide a comprehensive analysis of the current state art in ion-doped CP-based orthopaedic dental implant applications. Specifically, this evaluates effects ion addition on physicochemical, mechanical, biological properties CP coatings. The also identifies contribution additional (in separate or synergistic way) different components used together with advanced composite In final part, antibacterial specific bacteria strains are reported. present could be interest researchers, clinicians, industry professionals involved development application implants.

Language: Английский

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Biomaterials Based on Organic Polymers and Layered Double Hydroxides Nanocomposites: Drug Delivery and Tissue Engineering

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(2), P. 413 - 413

Published: Jan. 26, 2023

The development of biomaterials has a substantial role in pharmaceutical and medical strategies for the enhancement life quality. This review work focused on versatile based nanocomposites comprising organic polymers class layered inorganic nanoparticles, aiming drug delivery (oral, transdermal, ocular delivery) tissue engineering (skin bone therapies). Layered double hydroxides (LDHs) are 2D nanomaterials that can intercalate anionic bioactive species between layers. layers hold metal cations confer intrinsic biological activity to LDHs as well biocompatibility. intercalation allows formation systems with elevated loading capacity modified release profiles promoted by ion exchange and/or solubilization. integration, antigenicity, stimulation collagen formation, among other beneficial characteristics LDH, have been observed vivo assays. association properties biocompatible LDH-drug nanohybrids produces multifunctional compatible living matter. Such stimuli-responsive, show appropriate mechanical properties, be prepared creative methods allow fine-tuning release. They processed end form films, beads, gels, monoliths etc., reach orientated therapeutic applications. Several studies attest higher performance polymer/LDH-drug nanocomposite compared hybrid or free drug.

Language: Английский

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3D-printed strontium-incorporated β-TCP bioceramic triply periodic minimal surface scaffolds with simultaneous high porosity, enhanced strength, and excellent bioactivity

Journal of Advanced Ceramics, Journal Year: 2023, Volume and Issue: 12(9), P. 1671 - 1684

Published: July 17, 2023

In bone tissue engineering, scaffolds with excellent mechanical and bioactive properties play prominent roles in space maintaining regeneration, attracting increasingly interests clinical practice. this study, strontium-incorporated β-tricalcium phosphate (β-TCP), named Sr-TCP, bioceramic triply periodic minimal surface (TPMS) structured were successfully fabricated by digital light processing (DLP) based 3D printing technique, achieving high porosity, enhanced strength bioactivity. The Sr-TCP first characterized element distribution, macro- microstructure, properties. Notably, the compressive of reached 1.44 MPa a porosity 80%, bringing great breakthrough to porous scaffolds. Furthermore, also facilitated osteogenic differentiation mouse osteoblastic cell line (MC3T3-E1) cells both gene protein aspects, verified alkaline phosphatase (ALP) activity polymerase chain reaction (PCR) assays. Overall, printed TPMS obtained boosted superior bioactivity at same time, serving as promising approach for regeneration.

Language: Английский

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Unraveling the potential of 3D bioprinted immunomodulatory materials for regulating macrophage polarization: State-of-the-art in bone and associated tissue regeneration

Bioactive Materials, Journal Year: 2023, Volume and Issue: 28, P. 284 - 310

Published: June 1, 2023

Macrophage-assisted immunomodulation is an alternative strategy in tissue engineering, wherein the interplay between pro-inflammatory and anti-inflammatory macrophage cells body determines fate of healing or inflammation. Although several reports have demonstrated that regeneration depends on spatial temporal regulation biophysical biochemical microenvironment biomaterial, underlying molecular mechanism behind still under consideration for developing immunomodulatory scaffolds. Currently, most fabricated platforms reported literature show regenerative capabilities a particular tissue, example, endogenous (e.g., bone, muscle, heart, kidney, lungs) exogenous skin eye). In this review, we briefly introduced necessity 3D scaffolds nanomaterials, focusing material properties their interaction with macrophages general readers. This review also provides comprehensive summary origin taxonomy, diverse functions, various signal transduction pathways during biomaterial-macrophage interaction, which particularly helpful scientists clinicians next-generation From clinical standpoint, discussed role biomaterial and/or nanomaterial composites macrophage-assisted engineering special focus bone associated tissues. Finally, expert opinion presented to address challenges future bioprinted materials engineering.

Language: Английский

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3D-printed dual-ion chronological release functional platform reconstructs neuro-vascularization network for critical-sized bone defect regeneration

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 465, P. 143015 - 143015

Published: April 19, 2023

Language: Английский

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Metal ions: the unfading stars of bone regeneration—from bone metabolism regulation to biomaterial applications

Biomaterials Science, Journal Year: 2023, Volume and Issue: 11(22), P. 7268 - 7295

Published: Jan. 1, 2023

Schematic representation of the basic regulatory strategies, metal ions commonly used, and ion-based biomaterials for bone regeneration presented in this review.

Language: Английский

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