Long COVID Through a Public Health Lens: An Umbrella Review

Public health reviews, Journal Year: 2022, Volume and Issue: 43

Published: March 15, 2022

Objectives: To synthesize existing evidence on prevalence as well clinical and socio-economic aspects of Long COVID. Methods: An umbrella review reviews a targeted synthesis their primary studies, including searches in four electronic databases, reference lists included reviews, related article relevant publications. Results: Synthesis 23 102 studies. Prevalence estimates ranged from 7.5% to 41% non-hospitalized adults, 2.3%–53% mixed adult samples, 37.6% hospitalized 2%–3.5% primarily children. Preliminary suggests that female sex, age, comorbidities, the severity acute disease, obesity are associated with Almost 50% studies reported some degree COVID-related social family-life impairment, long absence periods off work, adjusted workloads, loss employment. Conclusion: COVID will likely have substantial public health impact. Current is still heterogeneous incomplete. fully understand COVID, well-designed prospective representative samples be essential.

Language: Английский

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One-Year Trajectory of Cognitive Changes in Older Survivors of COVID-19 in Wuhan, China

JAMA Neurology, Journal Year: 2022, Volume and Issue: 79(5), P. 509 - 509

Published: March 8, 2022

Importance

Determining the long-term impact of COVID-19 on cognition is important to inform immediate steps in research and health policy.

Objective

To investigate 1-year trajectory cognitive changes older survivors.

Design, Setting, Participants

This cohort study recruited 3233 survivors 60 years who were discharged from 3 COVID-19–designated hospitals Wuhan, China, February 10 April 10, 2020. Their uninfected spouses (N = 466) as a control population. Participants with preinfection impairment, concomitant neurological disorder, or family history dementia excluded, well those severe cardiac, hepatic, kidney disease any kind tumor. Follow-up monitoring functioning decline took place at 6 12 months. A total 1438 438 individuals included final follow-up. was categorized nonsevere following American Thoracic Society guidelines.

Main Outcomes Measures

The main outcome change 1 year after patient discharge. Cognitive during first second 6-month follow-up periods assessed using Informant Questionnaire Decline Elderly Telephone Interview Status-40, respectively. Based observed 2 periods, trajectories classified into 4 categories: stable cognition, early-onset decline, late-onset progressive decline. Multinomial conditional logistical regression models used identify factors associated risk

Results

Among 1317 screened, participants treated for (691 male [48.05%] 747 female [51.95%]; median [IQR] age, 69 [66-74] years) (222 [50.68%] 216 [49.32%]; 67 completed 12-month incidence impairment months discharge 12.45%. Individuals cases had lower Status-40 scores than (median [IQR]: severe, 22.50 [16.00-28.00]; nonsevere, 30.00 [26.00-33.00]; control, 31.00 [26.00-33.00]). Severe higher (odds ratio [OR], 4.87; 95% CI, 3.30-7.20), (OR, 7.58; 3.58-16.03), 19.00; 9.14-39.51), while 1.71; 1.30-2.27) when adjusting sex, education level, body mass index, comorbidities.

Conclusions Relevance

In this study, survival an increase longitudinal highlighting importance measures deal challenge.

Language: Английский

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Age, Sex and Previous Comorbidities as Risk Factors Not Associated with SARS-CoV-2 Infection for Long COVID-19: A Systematic Review and Meta-Analysis

Journal of Clinical Medicine, Journal Year: 2022, Volume and Issue: 11(24), P. 7314 - 7314

Published: Dec. 9, 2022

Identification of predictors long COVID-19 is essential for managing healthcare plans patients. This systematic literature review and meta-analysis aimed to identify risk factors not associated with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, but rather potentially predictive the development COVID-19. MEDLINE, CINAHL, PubMed, EMBASE, Web Science databases, as well medRxiv bioRxiv preprint servers were screened through 15 September 2022. Peer-reviewed studies or preprints evaluating potential pre-SARS-CoV-2 infection long-lasting symptoms included. The methodological quality was assessed using Quality in Prognosis Studies (QUIPSs) tool. Random-effects meta-analyses calculation odds ratio (OR) performed those where a homogenous definition used. From 1978 identified, 37 peer-reviewed one Eighteen articles evaluated age, sixteen sex, twelve medical comorbidities Overall, single reported that old age seems be (n = 18); however, did reveal an association between 3; OR 0.86, 95% CI 0.73 1.03, p 0.17). Similarly, revealed female sex 16); which confirmed 7; 1.48, 1.17 1.86, 0.01). Finally, such pulmonary disease 4), diabetes 1), obesity 6), organ transplantation 1) also identified bias most (71%, n 27/38) moderate high. In conclusion, pooled evidence support advancing supported factor Long some previous comorbidities.

Language: Английский

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Prognostic Factors for Post-COVID-19 Syndrome: A Systematic Review and Meta-Analysis

Journal of Clinical Medicine, Journal Year: 2022, Volume and Issue: 11(6), P. 1541 - 1541

Published: March 11, 2022

Evidence shows that a substantial proportion of patients with COVID-19 experiences long-term consequences the disease, but predisposing factors are poorly understood. We conducted systematic review and meta-analysis to identify present during hospitalization associated an increased risk exhibiting new or persisting symptoms (Post-COVID-19 Syndrome, PCS). MedLine WebOfScience were last searched on 30 September 2021. included English language clinical trials observational studies investigating prognostic for PCS in adults previously hospitalized COVID-19, reporting at least one individual prospective follow-up minimum 12 weeks. Two authors independently assessed bias, which was judged generally moderate. Risk analysis if their association investigated by two studies. To summarize effect each factor (or group factors), odds ratios estimated using raw data. Overall, 20 articles met inclusion criteria, involving 13,340 patients. Associations statistically significant factors: female sex any (OR 1.52; 95% CI 1.27–1.82), mental health 1.67, 1.21–2.29) fatigue 1.54, 1.32–1.79); acute disease severity respiratory 1.66, 1.03–2.68). The I² statistics tests calculated quantify degree study heterogeneity. This is first measuring between sequelae. role as independent must be confirmed robust longitudinal longer follow-up. Identifying populations greatest can enable development targeted prevention management strategies. Systematic registration: PROSPERO CRD42021253467.

Language: Английский

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Long COVID: current definition

Infection, Journal Year: 2021, Volume and Issue: 50(1), P. 285 - 286

Published: Sept. 14, 2021

Language: Английский

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Post-COVID-19 syndrome, low-grade inflammation and inflammatory markers: a cross-sectional study

Current Medical Research and Opinion, Journal Year: 2022, Volume and Issue: 38(6), P. 901 - 909

Published: Feb. 15, 2022

Post-COVID syndrome (PCS) is a poorly known entity. An underlying chronic, low-grade inflammation (LGI) has been theorized as pathophysiological mechanism. Available data on biomarkers in PCS show conflicting results. Our aim was to know whether subjects with present higher levels of inflammatory markers, after mild COVID-19.Analytical cross-sectional study. Cases COVID-19 community setting were included. We collected epidemiological (age, sex, BMI, smoking, comorbidities), variables the acute (duration, symptoms), and at 3 months phase (symptoms laboratory test). Serum C-reactive protein (CRP), neutrophil lymphocyte counts, neutrophil/lymphocyte ratio (NLR), lactate dehydrogenase, ferritin, fibrinogen, D-dimer analysed. LGI defined CRP >0.3 <1.0 mg/dL. A subject classified + if presented signs symptoms >12 weeks an infection consistent COVID-19. Five composite indices (C1-C5) developed, combining upper ranges distributions. Multivariate analyses performed.We analysed 121 cases (mean age = 45.7 years, 56.2% women). Among symptoms, women frequency fatigue (54.4% vs 30.2%; p .008). affected 35.8% 20.8% men (p .07), most reported (42.8%), anosmia (40%), ageusia (22.8%), dyspnea (17.1%) myalgia (11.4%). Neutrophil count, NLR, fibrinogen showed best correlations selected develop indices. In PCS+, C1, C3 C4 more frequently met, while C2, C5 range LGI. Anosmia, related sex differences. Fibrinogen persistent (510 ± 82 mg/dL 394 87; .013). multivariable analysis, woman count above median, or level NLR highest tertile, had 4-5-fold increased risk prevalent PCS. man LGI, 10-17-fold PCS.The obtained study seems demonstrate association between range. Furthermore, appear useful detecting relationships slight elevations PCS, our identifies relevant differences markers regarding

Language: Английский

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Cognitive impairment in people with previous COVID-19 infection: A scoping review

Cortex, Journal Year: 2022, Volume and Issue: 154, P. 212 - 230

Published: June 11, 2022

Language: Английский

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Post-exertional malaise among people with long COVID compared to myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)

Work, Journal Year: 2023, Volume and Issue: 74(4), P. 1179 - 1186

Published: March 10, 2023

BACKGROUND: Long COVID describes a condition with symptoms that linger for months to years following acute COVID-19. Many of these are like those experienced by patients myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). OBJECTIVE: We wanted determine if people post-exertional malaise (PEM), the hallmark symptom ME/CFS, and so, how it compared PEM ME/CFS. METHODS: A questionnaire asked about domains including triggers, experience, recovery, prevention was administered 80 seeking care at Bateman Horne Center. Their responses were given 151 ME/CFS using chi-square tests independence. RESULTS: All but one respondent reported having PEM. There many significant differences in types during PEM, ways recover prevent between Similarities included low medium physical cognitive exertion trigger fatigue, pain, immune reaction, neurologic, orthostatic intolerance, gastrointestinal rest from pacing CONCLUSION: People experience This may be due newness COVID, not knowing what exertional intolerance is or manage it.

Language: Английский

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Prevalence and characteristics of long COVID in elderly patients: An observational cohort study of over 2 million adults in the US

PLoS Medicine, Journal Year: 2023, Volume and Issue: 20(4), P. e1004194 - e1004194

Published: April 17, 2023

Incidence of long COVID in the elderly is difficult to estimate and can be underreported. While sometimes considered a novel disease, many viral or bacterial infections have been known cause prolonged illnesses. We postulate that some influenza patients might develop residual symptoms would satisfy diagnostic criteria for COVID, condition we call "long Flu." In this study, incidence Flu among Medicare using World Health Organization (WHO) consensus definition. compare incidence, symptomatology, healthcare utilization between patients.

Language: Английский

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Definition and measurement of post-COVID-19 conditions in real-world practice: a global systematic literature review

BMJ Open, Journal Year: 2024, Volume and Issue: 14(1), P. e077886 - e077886

Published: Jan. 1, 2024

Post-COVID-19 conditions (PCC) is an umbrella term that encompasses a range of signs, symptoms and present weeks after the acute phase SARS-CoV-2 infection. This systematic literature review summarises heterogeneous methodology used to measure PCC across real-world studies highlights trends by region, age group, follow-up period data source. Methods Medline, EMBASE Cochrane Library were searched supplemented with conference grey searches. Eligible included individuals (1) or (2) positive test COVID-19 diagnosis who followed over time. Included published in English between 1 January 2020 14 November 2022. Findings Of 291 publications included, 175 (60%) confirmed time for 116 (40%) prespecified definition. There was substantial heterogeneity study design, geography, conditions/symptoms assessed their classification duration follow-up. Among using definition, author-defined criteria (51%) more common than recommended major public health organisations (19%). Measurement periods outcomes from date primarily 3 <6 months (39.2%), 6 <12 (27.5%) <3 (22.9%). When classified organ/system, constitutional-related most frequently adult (86%) paediatric (87%) populations. Within constitutional symptoms, fatigue (91.6%) (95.0%) populations, fever/chills (37.9% 55%, respectively). Conclusions definitions are heterogenous studies, which limits reliable comparisons studies. However, some similarities observed terms measured PCC-associated symptoms/conditions, may aid clinical management patients PCC. CRD42022376111.

Language: Английский

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