Effect of sleep-disordered breathing on recovery in patients with “wake-up” stroke DOI Open Access
Л. С. Коростовцева, Mikhail Bochkarev, M. S. Golovkova-Kucheryavaya

et al.

Arterial’naya Gipertenziya (Arterial Hypertension), Journal Year: 2023, Volume and Issue: 29(6), P. 628 - 637

Published: Dec. 3, 2023

Background. Wake-up stroke (WUS) is often combined with sleep-disordered breathing and may potentially have a more unfavorable course. Objective — to evaluate the association between time of onset pattern breathing, as well effect wake-up on recovery severity in patients ischemic stroke. Design methods. We included 18–85 years old acute admitted within 24 hours symptom neurological resuscitation unit, performed polygraphy first day hospitalization assess parameters breathing. In 2018–2023, 2122 were screened, was 639 patients, data from 292 final analysis. Stroke assessed using NIHSS scale, type determined TOAST classification. WUS considered when symptoms detected upon awakening. Functional status by Barthel index, rehabilitation outcomes modified Rankin scale. The cumulative end point death any cause, new nonfatal myocardial infarction, stroke/transient attack, emergency revascularization, or due exacerbation cardiovascular disease. Results. 101 (34,6 %). group had frequent diabetes mellitus higher (p = 0,021) index 0,026) at discharge, less thrombolytic therapy endovascular procedures 0,007) which most cases associated beyond therapeutic window < 0,001). Endpoints reached 21,6 % median follow-up 209 days. No significant differences found main indices groups different pathogenetic factors related discharge 0,001) age influenced 0,006) admission Conclusions. Our study did not show previously described incidence WUS. best subjects who received reperfusion therapy. Patients should be hospitalized hospital where available. Lower values characterize their lower potential.

Language: Английский

Complex gene-dependent and-independent mechanisms control daily rhythms of hematopoietic cells DOI Open Access
Francesca Sciarra, Edoardo Franceschini, Gabriella Palmieri

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 183, P. 117803 - 117803

Published: Jan. 2, 2025

Language: Английский

Citations

1
Circadian rhythms in stem cells and their therapeutic potential DOI Creative Commons

Napasiri Putthanbut,

Pen‐Hua Su,

Jea-Young Lee

et al.

Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 23, 2025

Language: Английский

Citations

0
Associations of Rest‐Activity Rhythm Disturbances With Stroke Risk and Poststroke Adverse Outcomes DOI Creative Commons
Lei Gao, Xi Zheng,

Sarah N. Baker

et al.

Journal of the American Heart Association, Journal Year: 2024, Volume and Issue: 13(18)

Published: Sept. 5, 2024

Many disease processes are influenced by circadian clocks and display ~24-hour rhythms. Whether disruptions to these rhythms increase stroke risk is unclear. We evaluated the association between 24-hour rest-activity rhythms, risk, major poststroke adverse outcomes.

Language: Английский

Citations

2
Molecular circadian markers in acute ischemic stroke (preliminary results) DOI Open Access
Л. С. Коростовцева,

E. N. Zabroda,

Sergey Kolomeichuk

et al.

Arterial’naya Gipertenziya (Arterial Hypertension), Journal Year: 2024, Volume and Issue: 30(3), P. 282 - 291

Published: June 14, 2024

Background. Ischemic stroke is the leading cause of mortality and loss working ability. Sleep disorders sleep-wake rhythm are considered to be a potential modifiable risk factor acute stroke. Objective. To determine peculiarities circadian rhythms in by assessing daily variation urinary excretion cortisol 6-sulfatoxymelatonin. Materials methods. We examined 27 patients with ischemic 9 admitted hospital suspected but not confirmed All examinations both groups were performed similar settings. underwent neurological assessment phase before discharge including evaluation National Institute Health Stroke Scale, modified Rankin scale (mRs), Barthel index Rivermead index. Within 48–72 hours after admission, urine samples collected at 7 a. m., 3 p. m. 11 for 6-sulfatoxymelatonin (enzyme-linked immunosorbent assay analysis). Results. Daily did differ control subjects. However, demonstrated highest values evening while subjects had higher levels morning. The preserved level show lower all time points (by 45 %, 33 % 72 morning, afternoon evening, respectively). There no changes either or depending on severity. Afternoon correlates (ρ = 0,63; p 0,004), mRs score –0,65; 0,003) admission 0,52; 0,024) 0,49; 0,032). Conclusion. Patients mild-moderate abnormal maximum evening. night, have compared

Language: Английский

Citations

0
Midday Dipping and Circadian Blood Pressure Patterns in Acute Ischemic Stroke DOI Open Access
Nikolaos Kakaletsis, George Ntaios, Haralampos Milionis

et al.

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(14), P. 4816 - 4816

Published: July 21, 2023

The purpose of this study was to investigate the alterations in blood pressure (BP) during midday and changes circadian BP patterns acute phase ischemic stroke (AIS) with severity their predictive role outcomes within 3 months. A total 228 AIS patients (a prospective multicenter follow-up study) underwent 24 h ambulatory monitoring (ABPM). Mean parameters day (7:00–22:59), (13:00–16:59), night (23:00–6:59), nocturnal dipping were calculated. Midday SBP dippers had less severe stroke, lower incidence hypertension SBP/DBP on admission, levels serum glucose WBCs, delayed initiation ABPM compared risers. There a reverse relation between both severity. “double dippers” (midday dipping) least lowest heart rate from ABPM, risk an unfavorable outcome, while risers” opposite results, by approximately five-fold death/disability at These findings indicate different AIS, which could be considered marker prognosis.

Language: Английский

Citations

1
Study on the circadian rhythm and sleep state characteristics of patients with acute cerebral infarction accompanied by sleep-breathing disorders DOI Creative Commons
Lianhui Wang, Xiaodong Yuan, Ya Ou

et al.

Sleep and Biological Rhythms, Journal Year: 2024, Volume and Issue: 22(3), P. 353 - 362

Published: March 15, 2024

There is limited research on the circadian rhythm and sleep state in patients with acute cerebral infarction (ACI) accompanied by sleep-breathing disorders (SDB). This study aims to provide a scientific basis for individualized diagnosis treatment stroke-related SDB patients. The SC-500 monitor was used continuously 1367 ACI over 5 days. Based apnea–hypopnea index (AHI), were divided into non-SDB group (normal) (mild, moderate, severe, fluctuating). Interdaily stability (IS) intradaily variability (IV) calculated through heart rate monitoring, states their correlations analyzed. Compared group, moderate-to-severe showed decreased IS, increased IV, fragmentation. Significant statistical differences observed total time (TST), rapid eye movement latency (REML), efficiency (SE), non-rapid stages 1–2 (NREM stages1–2), 3–4 3–4), proportion of (NREM%), wake after onset (WASO), number awakenings (NOA) between (P < 0.05). AHI strong negative correlation IS positive IV. positively correlated (SL), REML, NREM stages1–2, NREM%, (REM%), WASO, out bed (TOB), NOA, negatively TST, SE, 3–4, (REM), all significance significant Mini-Mental State Examination (MMSE) without SDB, among mild, fluctuating groups Patients are more likely experience changes states, which turn affect cognitive functions.

Language: Английский

Citations

0
Clinical implication of time of stroke among post stroke survivors from eastern India: A circadian perspective DOI Creative Commons

Dipanwita Sadhukhan,

Arunima Roy, Tapas Kumar Banerjee

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 10, 2024

Abstract Introduction The circadian variation in stroke occurrence is a well-documented phenomenon. However, the effect on outcome, particularly post-stroke cognition, not yet been fully elucidated. Aims and objective We aim to evaluate influence of diurnal onset upon cognition development depression. Materials Methods Based 4-hourly time period occurrence, 249 recruited cohorts were categorized into 6 groups. Several clinical cognitive parameters compared among Then, mRNA expression core clock genes Peripheral Blood Mononuclear Cells quantified correlated with post outcome 24 acute phase cases day-time or night-time occurrence. Furthermore, genetic susceptibility towards higher number morning examined by genotyping CLOCK (rs1801260T/C, rs4580704G/C) CRY2 (rs2292912C/G) variants 292 controls. Results conclusion Among six subgroups, subgroup-1 represents nocturnal-onset cases; they identified have NIHSS score (12.2±5.67) at admission than other subgroups (8.73±5.92). In same cohort, more diabetic individuals fasting blood sugar level (186.57±93.40) was also observed. After months, those had prevalence language impairment depression score. A significant decrease BMAL1 CRY1 raw for depression; data nocturnal further established our observation. incidence day did reveal any correlation.

Language: Английский

Citations

0
Clinical Implication of Time of Ischaemic Stroke Among Post-Stroke Survivors from Eastern India: A Circadian Perspective DOI

Dipanwita Sadhukhan,

Arunima Roy, Tapas Kumar Banerjee

et al.

NeuroMolecular Medicine, Journal Year: 2024, Volume and Issue: 26(1)

Published: Oct. 14, 2024

Language: Английский

Citations

0
Effect of sleep-disordered breathing on recovery in patients with “wake-up” stroke DOI Open Access
Л. С. Коростовцева, Mikhail Bochkarev, M. S. Golovkova-Kucheryavaya

et al.

Arterial’naya Gipertenziya (Arterial Hypertension), Journal Year: 2023, Volume and Issue: 29(6), P. 628 - 637

Published: Dec. 3, 2023

Background. Wake-up stroke (WUS) is often combined with sleep-disordered breathing and may potentially have a more unfavorable course. Objective — to evaluate the association between time of onset pattern breathing, as well effect wake-up on recovery severity in patients ischemic stroke. Design methods. We included 18–85 years old acute admitted within 24 hours symptom neurological resuscitation unit, performed polygraphy first day hospitalization assess parameters breathing. In 2018–2023, 2122 were screened, was 639 patients, data from 292 final analysis. Stroke assessed using NIHSS scale, type determined TOAST classification. WUS considered when symptoms detected upon awakening. Functional status by Barthel index, rehabilitation outcomes modified Rankin scale. The cumulative end point death any cause, new nonfatal myocardial infarction, stroke/transient attack, emergency revascularization, or due exacerbation cardiovascular disease. Results. 101 (34,6 %). group had frequent diabetes mellitus higher (p = 0,021) index 0,026) at discharge, less thrombolytic therapy endovascular procedures 0,007) which most cases associated beyond therapeutic window < 0,001). Endpoints reached 21,6 % median follow-up 209 days. No significant differences found main indices groups different pathogenetic factors related discharge 0,001) age influenced 0,006) admission Conclusions. Our study did not show previously described incidence WUS. best subjects who received reperfusion therapy. Patients should be hospitalized hospital where available. Lower values characterize their lower potential.

Language: Английский

Citations

0