Orexin increases the neuronal excitability of several brain areas associated with maintaining of arousal DOI Open Access
Xinyi Chen, Wu Yang, Yan Xue

et al.

Journal of Neurochemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 2, 2024

Orexin is exclusively produced in neurons localized within the lateral hypothalamic area (LHA) and perifornical (PFA). has been identified as a key promotor of arousal. The selective loss orexinergic results narcolepsy. It known that intrinsic electrophysiological properties are critical for to perform their functions corresponding brain regions. In addition orexin, other nuclei involved regulation sleep wakefulness. Quite lot studies focus on elucidating orexin-induced sleep-wake states modulation neuronal several Here, we summarize exhibit spontaneous firing activity which associated with cycle. mainly exerts postsynaptic excitatory effects multiple process This review may provide background guide future research about cellular mechanisms maintaining

Language: Английский

Dual orexin receptor antagonists as promising therapeutics for Alzheimer’s disease DOI Creative Commons

Sydney M. Ragsdale,

John M. Radovich,

Isabel I. Coiduras

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: 2(1)

Published: March 8, 2025

We examine the relationship between sleep, glymphatics and Alzheimer's disease (AD), recent work questioning glymphatic clearance during sleep. highlight a need for understanding and/or other mechanism of review flow measurement methods. Further, we explore dual orexin receptor antagonists (DORAs) potential to mitigate AD sleep disturbances enhance clearance. Further research could elucidate linkage DORAs, improved reducing pathophysiology.

Language: Английский

Citations

0
Efficacy and safety of Lemborexant in treating adult patients with insomnia in China: a single-center, retrospective observational study DOI Creative Commons

Weiying Jian,

Minyan Feng, Yifan Zhao

et al.

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: March 14, 2025

Except for one case report, there has been no published study of Lemborexant treatment patients with insomnia in China. This investigated efficacy and safety treating Chinese insomnia. In this single-center, retrospective observational study, adult diagnosed an Insomnia Severity Index (ISI) score ≥8 who were prescribed at Guangzhou United Family Hospital from January 2023 to July 2024 had ≥2 follow-up ISI assessment(s) included. The primary outcome was change the total baseline after 4 weeks treatment. Treatment-emergent adverse events (TEAEs) collected. Forty a mean 17.0 ± 3.3 continuation rate during median 8-week (range: 2-20) 90%. reduced significantly (-10.2 3.0, p < 0.001), further 8 (-12.7 3.7, 0.001). Significant improvement week over also observed. Both Patient Health Questionnaire-9 General Anxiety Disorder-7 scores improved Thirty five (87.5%) responders (ISI 8). Age, combination therapy 10 mg qn independent factors associated responders. One (2.5%) patient experienced mild dizziness. No discontinued due TEAE(s). effective safe wide variety different symptom(s)

Language: Английский

Citations

0
Comparison of efficacy and safety of dual orexin receptor antagonists lemborexant and daridorexant for the treatment of insomnia: a systematic review and meta-analysis DOI
Ming Tang,

Ziyi Shen,

Peilu Yu

et al.

Psychopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Language: Английский

Citations

0
Current and Emerging Sleep Interventions for Older Adults with or without Mild Cognitive Impairment DOI Creative Commons
Anastasia Suraev, Shawn Dexiao Kong, Zoe Menczel Schrire

et al.

Current Treatment Options in Neurology, Journal Year: 2024, Volume and Issue: 26(11), P. 463 - 483

Published: Sept. 4, 2024

Language: Английский

Citations

2
Orexin Receptor Antagonists for the Prevention and Treatment of Alzheimer’s Disease and Associated Sleep Disorders DOI Creative Commons
Matteo Carpi, Nicola Biagio Mercuri, Claudio Liguori

et al.

Drugs, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 4, 2024

Orexins/hypocretins are neuropeptides produced by the hypothalamic neurons, binding two G-protein coupled receptors (orexin 1 and orexin 2 receptors) playing a critical role in regulating arousal, wakefulness, various physiological functions. Given high prevalence of sleep disturbances Alzheimer's disease (AD) their reported involvement AD pathophysiology, system is hypothesized to contribute pathogenesis. Specifically, recent evidence suggests that orexin's influence may extend beyond regulation, potentially affecting amyloid-β tau pathologies. Dual receptor antagonists (DORAs), namely suvorexant, lemborexant, daridorexant, demonstrated efficacy treating chronic insomnia disorder across diverse clinical populations. Considering stabilizing effects on parameters emerging possible neuroprotective role, these agents represent promising strategy for management. This leading article reviews potential use AD, particularly focusing effect modulating disease-associated outcomes. Overall, studies support DORAs enhance quality patients with comorbid circadian sleep-wake rhythm disorders. Preliminary results also suggest compounds might pathology, progression. Conversely, research selective currently limited. Further investigation needed explore antagonism not only as symptomatic treatment disturbances, but its broader implications modifying neurodegeneration, emphasizing mechanisms action long-term

Language: Английский

Citations

2
Orexin increases the neuronal excitability of several brain areas associated with maintaining of arousal DOI Open Access
Xinyi Chen, Wu Yang, Yan Xue

et al.

Journal of Neurochemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 2, 2024

Orexin is exclusively produced in neurons localized within the lateral hypothalamic area (LHA) and perifornical (PFA). has been identified as a key promotor of arousal. The selective loss orexinergic results narcolepsy. It known that intrinsic electrophysiological properties are critical for to perform their functions corresponding brain regions. In addition orexin, other nuclei involved regulation sleep wakefulness. Quite lot studies focus on elucidating orexin-induced sleep-wake states modulation neuronal several Here, we summarize exhibit spontaneous firing activity which associated with cycle. mainly exerts postsynaptic excitatory effects multiple process This review may provide background guide future research about cellular mechanisms maintaining

Language: Английский

Citations

1