Efficacy of Repeated Low-Level Red-Light Therapy for Slowing the Progression of Childhood Myopia: A Systematic Review and Meta-analysis

American Journal of Ophthalmology, Journal Year: 2023, Volume and Issue: 252, P. 153 - 163

Published: April 7, 2023

Language: Английский

---

Red light instruments for myopia exceed safety limits

Ophthalmic and Physiological Optics, Journal Year: 2024, Volume and Issue: 44(2), P. 241 - 248

Published: Jan. 5, 2024

Low-level red light (LLRL) therapy has recently emerged as a myopia treatment in children, with several studies reporting significant reduction axial elongation and progression. The goal of this study was to characterise the output determine thermal photochemical maximum permissible exposure (MPE) LLRL devices for control.

Language: Английский

---

Photobiomodulation therapy retarded axial length growth in children with myopia: evidence from a 12-month randomized controlled trial evidence

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Feb. 27, 2023

Abstract To determine whether photobiomodulation (PBM) therapy can retard ocular axial length (AL) in children with myopia. A randomized controlled clinical trial was conducted on two consecutive cohorts of 50 eligible aged 8–12 years ≤ − 0.75 Diopter (D) spherical equivalent refraction (SER). Participants were randomly assigned to the intervention group (n = 25) and treated PBM or control single vision spectacles only. At 12-month follow-up, changes AL cycloplegic SER from baseline both compared between groups. In addition, subfoveal choroidal thickness (SFChT), anterior chamber depth (ACD), central corneal refractive power (CCP) analysed at 3-, 6-, 9-, follow-ups, respectively. Among children, 78% included final a mean age 9.7 ± 1.5 2.56 1.70. The difference growth groups 12 months 0.50 mm (PBM vs. Control, 0.02 0.11 0.48 0.16, P < 0.001), + 1.25 D 0.28 0.26 0.97 0.25, 0.001). There no significant differences any other parameters (including SFChT, ACD, CCP) time point. is an effective for slightly decreasing myopia children. Trial registration : Chinese Clinical Registration Number: ChiCTR2100043619. Registered 23/02/2021; prospectively registered. http://www.chictr.org.cn/showproj.aspx?proj=121302 .

Language: Английский

---

Repeated Low-Level Red-Light Therapy for Controlling Onset and Progression of Myopia-a Review

International Journal of Medical Sciences, Journal Year: 2023, Volume and Issue: 20(10), P. 1363 - 1376

Published: Jan. 1, 2023

Repeated low-level red-light (RLRL), characterized by increased energy supply and cellular metabolism, thus enhancing metabolic repair processes, has gained persistent worldwide attention in recent years as a new novel scientific approach for therapeutic application myopia.This revolution led RLRL therapy is due to significant advances bioenergetics photobiology, instance, enormous progresses photobiomodulation regulated cytochrome c oxidase, the primary photoreceptor of light red near infrared regions electromagnetic spectrum, mechanism action therapy.This oxidase also key mitochondrial enzyme bioenergetics, especially nerve cells retina brain.In addition, dopamine (DA)-enhanced release nitric oxide may be involved controlling myopia activation synthase, cGMP signaling.Recent evidence suggested that inhibit progression inhibiting spherical equivalent refraction (SER) axial elongation without adverse effects.In this review, we provide unique paradigm control support theory targeting neuronal metabolism constitute major target neurotherapeutics myopia, with emphasis on its molecular, cellular, nervous tissue levels, potential benefits myopia.

Language: Английский

---

Myopia Control Effect of Repeated Low-Level Red-Light Therapy Combined with Orthokeratology

Ophthalmology, Journal Year: 2024, Volume and Issue: 131(11), P. 1304 - 1313

Published: May 18, 2024

Language: Английский

---

Wavelength‐Selective Photodetector and Neuromorphic Visual Sensor Utilizing Intrinsic Defect Semiconductor

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(46)

Published: July 15, 2024

Abstract With the rapid developments of Artificial Intelligence (AI) and Internet Things (IoT), increasingly intricate expanding application scenarios are placing higher demands on current machine vision capabilities. Therefore, there is a pressing need to simultaneously achieve diverse functionalities, simple designs, efficient computing in devices. Here, study develops two‐terminal optoelectronic device utilizing single 2D intrinsic defect semiconductor In 2 S 3 . The demonstrates wavelength‐selective photodetection neuromorphic visual capabilities, attributed defect‐related charge‐trapping/de‐trapping processes. As photodetector, exhibits high photoresponsivity 473.6 A W −1 , external quantum efficiency 1.6 × 10 5 %, fast rise/fall time 0.3/1.4 ms at wavelength 359 nm. an all‐in‐one device, optoelectronic‐driven fundamental synaptic functions, including paired‐pulse facilitation (PPF), short‐term plasticity (STP), long‐term (LTP), “learning‐experience”, successfully mimicked 671 Moreover, one‐shot recognition 12‐letter image “SHAN XI NORMAL” achieved through artificial convolutional neural network. This provides new strategy for developing compact high‐level intelligence systems complex scenarios.

Language: Английский

---

Real-world outcomes of Defocus Incorporated Multiple Segments lenses on retarding axial elongation in myopic children and adolescents

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 24, 2025

Purpose This study aimed to examine the effect of Defocus Incorporated Multiple Segments (DIMS) lenses on myopia progression and axial elongation in a clinical population. Methods A retrospective was conducted using data from 489 156 patients aged 3 17 years old who were prescribed DIMS single vision (SV) lenses, respectively at Optometry Clinic The Hong Kong Polytechnic University between July 2018 August 2019. included with previous control interventions. changes spherical equivalent refraction (SER) length (AL) measured normalized annual changes. correlation age baseline change AL also examined. Results total SER after −0.94 ± 0.79D 0.55 0.40 mm, an average wearing period 31.98 9.97 months. wearers significantly smaller than those SV (DIMS; vs. changes; −0.38 0.32D 0.22 0.16 mm. SV; −0.45 0.41D 0.29 0.20 p &lt; 0.05). Patients history had greater lenses. There significant negative (correlation coefficient, r = −0.61, 0.001), suggesting that faster children younger onset. small proportion (2.7%) experienced clinically shortening (total AL:−0.13 0.07 mm) more 2 years. Conclusion demonstrated could retard elongation, sustained increased duration lens wear. However, highlighted potential for These findings underscore importance adherence intervention achieving optimal treatment efficacy. Further research is needed understand mechanisms underlying these effects optimize use optical interventions control.

Language: Английский

---

Short-term effectiveness and safety of photobiomodulation on low-to-moderate myopia

Lasers in Medical Science, Journal Year: 2025, Volume and Issue: 40(1)

Published: Feb. 15, 2025

Language: Английский

---

Long-term effect of repeated low-level red light therapy on myopia control: A systematic review and meta-analysis

European Journal of Ophthalmology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

Introduction Myopia is a refractive error where distant objects are not clearly seen and appear blurred. Goal of this study was to evaluate long-term effectiveness Repeated Low-Level Red Light (RLRL) therapy for children with myopia, which primarily focused on Axial length (AL) Spherical Equivalent Refraction (SER) as primary endpoints. Methods The research compared outcomes between RLRL treatment Single Vision Spectacles (SVS) childhood myopia management. We performed systematic literature search in the PubMed, Embase Cochrane databases using “Myopia” “ “. Mean differences (MD) were estimated effects therapies measured. Publication bias heterogeneity analysis carried out by Inverted Precision Effect Test-Precision Estimate Standard Error (PET-PEESE) (and subsequent Search Sequential Analysis) Tau test. Bayesian meta-analysis Jaffrey Amazing Statistical Package (JASP). Results This comprised 1,714 participants: 824 890 SVS group. Pooled effect size AL reduction 0.953 ± 0.294, (95% credible interval (CI) 0.775 0.980). SER 1.521 0.662 CI 0.102 2.736). PET-PEESE revealed no significant publication ( p-value 0.407). Random models employed presence (3.9 5.7 AL; SER), alongside degree variation (0.828 & 1.665) (τ), estimates between-study variance. Conclusion Long-term observations indicate that significantly influences management, leading considerable reductions both SER. Additional essential investigate potential rebound effects.

Language: Английский

---

Axial Length Stabilization or Reduction in over 40% of Patients Wearing Extended Depth-of-Focus Contact Lenses

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(5), P. 1750 - 1750

Published: March 5, 2025

Background/Objectives: Preceding studies have reported the efficacy of multifocal contact lenses (MFCLs) in slowing myopia progression. Recently, a novel type MFCL, i.e., extended depth-of-focus (EDOF) lens (CL), was designed. Here, we retrospectively investigated progression associated with EDOF CL wear. Methods: Twenty-four consecutive myopic children (24 eyes; mean age, 13.9 years) received CLs to control and participated study. We measured axial length (AL), spherical equivalent (SE), choroidal thickness (CT) at baseline after 1 year wear compared changes. Results: The AL, SE, CT were, respectively, 26.31 mm, -6.38 diopter (D), 235 μm, 26.40 mm (p = 0.03), -6.61 D 0.05), 244 μm 0.18). AL decreased 20.8% cases (≧-0.05 mm/year), whereas 58.4% had stabilization or an increased (≧+0.05 respectively. patients engaged outdoor activity time 200.6 min/day, mm/year) 126.7 min/day. change correlated significantly (β -0.46, p < 80% shortened (≧+20 μm/year). Conclusions: Our data showed that stabilized over 40% wearing CLs.

Language: Английский

---