Chromatische Pupillometrie – ein neuer Weg zur funktionellen Glaukomdiagnostik? DOI
Cord Huchzermeyer

Klinische Monatsblätter für Augenheilkunde, Journal Year: 2023, Volume and Issue: 240(12), P. 1350 - 1358

Published: Sept. 7, 2023

Chromatic pupillometry allows quantification of photoreceptor-driven (extrinsic) and melanopsin-driven (intrinsic) responses the intrinsic-photosensitive retinal ganglion cells (ipRGCs). This small subpopulation is also affected by glaucoma, making chromatic a potential diagnostic tool. Studies show reduced phasic tonic in glaucoma patients. The value earlier studies depended on technical details study design. purpose this article to give an introduction into principles discuss applications management glaucoma.Die chromatische Pupillometrie erlaubt die Quantifizierung der photorezeptorvermittelten (extrinsischen) und melanopsinvermittelten (intrinsischen) Antwort intrinsisch-photosensitiven retinalen Ganglienzellen Diese kleine Subpopulation wird beim Glaukom ebenfalls geschädigt, somit ist für Glaukomdiagnostik potenziell interessant. Die bisherigen Studien zeigen sowohl eine Verminderung phasischen als auch tonischen Glaukom. diagnostische Wertigkeit unterschied sich abhängig von verwendeten Technik dem Studiendesign. Der vorliegende Artikel soll vor allem Grundlagen chromatischen potenziellen Anwendungen darstellen.

Comparison of an AI-based mobile pupillometry system and NPi-200 for pupillary light reflex and correlation with glaucoma-related markers DOI Creative Commons
Damian Jaworski, Karolina Suwała, Bartłomiej J. Kałużny

et al.

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 9, 2025

Glaucoma is a leading cause of blindness, often progressing asymptomatically until significant vision loss occurs. Early detection crucial for preventing irreversible damage. The pupillary light reflex (PLR) has proven useful in glaucoma diagnosis, and mobile technologies like the AI-based smartphone pupillometer (AI Pupillometer) offer promising solution accessible screening. This study assesses reliability AI Pupillometer detecting glaucoma. In Experiment 1, 20 healthy participants were assessed using both NPi-200 device to evaluate equivalence measuring PLR. Each eye underwent three trials. 2 included 46 participants, 24 with primary open-angle (POAG) 22 controls. PLR measurements from correlated structural functional ocular parameters. An additional expanded sample 387 (103 patients, 284 controls), focusing on differential pupillometry parameters minimize ambient interference. demonstrated strong correlations key initial pupil size (r = 0.700), constricted 0.755), constriction velocity 0.541), confirming its reliability. 2, although no statistically differences light-corrected found between groups, patients had marginally higher (p 0.1632). Significant observed advanced imaging results, notably amplitude visual field loss. revealed 0.014) relative change 0.0072) controls, reinforcing Pupillometer's diagnostic potential. confirms as reliable, tool Mobile diagnostics could enhance early detection, improving outcomes patients.

Language: Английский

Citations

1
Basics, benefits, and pitfalls of pupillometers assessing visual function DOI

M. Barbara Philibert,

Dan Miléa

Eye, Journal Year: 2024, Volume and Issue: 38(12), P. 2415 - 2421

Published: May 27, 2024

Language: Английский

Citations

2
Chromatische Pupillometrie – ein neuer Weg zur funktionellen Glaukomdiagnostik? DOI
Cord Huchzermeyer

Klinische Monatsblätter für Augenheilkunde, Journal Year: 2023, Volume and Issue: 240(12), P. 1350 - 1358

Published: Sept. 7, 2023

Chromatic pupillometry allows quantification of photoreceptor-driven (extrinsic) and melanopsin-driven (intrinsic) responses the intrinsic-photosensitive retinal ganglion cells (ipRGCs). This small subpopulation is also affected by glaucoma, making chromatic a potential diagnostic tool. Studies show reduced phasic tonic in glaucoma patients. The value earlier studies depended on technical details study design. purpose this article to give an introduction into principles discuss applications management glaucoma.Die chromatische Pupillometrie erlaubt die Quantifizierung der photorezeptorvermittelten (extrinsischen) und melanopsinvermittelten (intrinsischen) Antwort intrinsisch-photosensitiven retinalen Ganglienzellen Diese kleine Subpopulation wird beim Glaukom ebenfalls geschädigt, somit ist für Glaukomdiagnostik potenziell interessant. Die bisherigen Studien zeigen sowohl eine Verminderung phasischen als auch tonischen Glaukom. diagnostische Wertigkeit unterschied sich abhängig von verwendeten Technik dem Studiendesign. Der vorliegende Artikel soll vor allem Grundlagen chromatischen potenziellen Anwendungen darstellen.

Citations

0