The blood–brain barrier: Structure, regulation and drug delivery

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: May 25, 2023

Abstract Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous system (CNS) from toxins and pathogens in blood. However, the presence of BBB complicates pharmacotherapy for CNS disorders as most chemical drugs biopharmaceuticals have been impeded to enter brain. Insufficient drug delivery into brain leads low therapeutic efficacy well aggravated side effects due accumulation other organs tissues. Recent breakthrough materials science nanotechnology provides library advanced with customized structure property serving powerful toolkit targeted delivery. In-depth research field anatomical pathological study on further facilitates development brain-targeted strategies enhanced crossing. In this review, physiological different cells contributing are summarized. Various emerging permeability regulation crossing including passive transcytosis, intranasal administration, ligands conjugation, coating, stimuli-triggered disruption, overcome obstacle highlighted. Versatile systems ranging organic, inorganic, biologics-derived their synthesis procedures unique physio-chemical properties summarized analyzed. This review aims provide an up-to-date comprehensive guideline researchers diverse fields, offering perspectives system.

Language: Английский

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Additive manufacturing of sustainable biomaterials for biomedical applications

Asian Journal of Pharmaceutical Sciences, Journal Year: 2023, Volume and Issue: 18(3), P. 100812 - 100812

Published: April 27, 2023

Biopolymers are promising environmentally benign materials applicable in multifarious applications. They especially favorable implantable biomedical devices thanks to their excellent unique properties, including bioactivity, renewability, bioresorbability, biocompatibility, biodegradability and hydrophilicity. Additive manufacturing (AM) is a flexible intricate technology, which widely used fabricate biopolymer-based customized products structures for advanced healthcare systems. Three-dimensional (3D) printing of these sustainable applied functional clinical settings wound dressing, drug delivery systems, medical implants tissue engineering. The present review highlights recent advancements different types biopolymers, such as proteins polysaccharides, employed develop by using extrusion, vat polymerization, laser inkjet 3D techniques addition normal bioprinting four-dimensional (4D) techniques. This also incorporates the influence nanoparticles on biological mechanical performances 3D-printed scaffolds. work addresses current challenges well future developments friendly polymeric manufactured through AM Ideally, there need more focused research adequate blending biodegradable biopolymers achieving useful results targeted areas. We envision that composites have potential revolutionize sector near future.

Language: Английский

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Poly(Lactic Acid)-Based Microparticles for Drug Delivery Applications: An Overview of Recent Advances

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(2), P. 359 - 359

Published: Feb. 4, 2022

The sustained release of pharmaceutical substances remains the most convenient way drug delivery. Hence, a great variety reports can be traced in open literature associated with delivery systems (DDS). Specifically, use microparticle has received special attention during past two decades. Polymeric microparticles (MPs) are acknowledged as very prevalent carriers toward an enhanced bio-distribution and bioavailability both hydrophilic lipophilic substances. Poly(lactic acid) (PLA), poly(lactic-co-glycolic (PLGA), their copolymers among frequently used biodegradable polymers for encapsulated drugs. This review describes current state-of-the-art research study poly(lactic acid)/poly(lactic-co-glycolic PLA-copolymers other aliphatic acids devices increasing efficiency delivery, enhancing profile, targeting active ingredients (API). Potential advances generics constant discovery therapeutic peptides will hopefully promote success microsphere technology.

Language: Английский

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PLGA/PLA-Based Long-Acting Injectable Depot Microspheres in Clinical Use: Production and Characterization Overview for Protein/Peptide Delivery

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(16), P. 8884 - 8884

Published: Aug. 18, 2021

Over the past few decades, long acting injectable (LAI) depots of polylactide-co-glycolide (PLGA) or polylactic acid (PLA) based microspheres have been developed for controlled drug delivery to reduce dosing frequency and improve therapeutic effects. Biopharmaceuticals such as proteins peptides are encapsulated in increase their bioavailability provide a release period (days months) with constant plasma concentration. The biodegradable biocompatible properties PLGA/PLA polymers, including but not limited molecular weight, end group, lactide glycolide ratio, minor manufacturing changes, could greatly affect quality attributes microsphere formulations profile, size, encapsulation efficiency, bioactivity biopharmaceuticals. Besides, proteins/peptides susceptible harsh processing conditions associated fabrication methods, exposure organic solvent, shear stress, temperature fluctuations. protein/peptide containing LAI clinical use is typically prepared by double emulsion, coacervation, spray drying techniques. purpose this review an overview formulation conventional techniques that currently protein/peptides. Furthermore, physicochemical characteristics deliberated.

Language: Английский

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PLGA-Based Nanomedicine: History of Advancement and Development in Clinical Applications of Multiple Diseases

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(12), P. 2728 - 2728

Published: Dec. 6, 2022

Research on the use of biodegradable polymers for drug delivery has been ongoing since they were first used as bioresorbable surgical devices in 1980s. For tissue engineering and delivery, polymer poly-lactic-co-glycolic acid (PLGA) shown enormous promise among all biomaterials. PLGA are a family FDA-approved that physically strong highly biocompatible have extensively studied vehicles drugs, proteins, macromolecules such DNA RNA. wide range erosion times mechanical properties can be modified. Many innovative platforms widely created development methods controlled PLGA. In this paper, various manufacturing processes characteristics impact their breakdown release explored depth. Besides different PLGA-based nanoparticles, preclinical clinical applications diseases platform types scale-up issues will discussed.

Language: Английский

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Comparative statistical analysis of the release kinetics models for nanoprecipitated drug delivery systems based on poly(lactic-co-glycolic acid)

PLoS ONE, Journal Year: 2022, Volume and Issue: 17(3), P. e0264825 - e0264825

Published: March 10, 2022

Poly(lactic-co-glycolic acid) is one of the most used polymers for drug delivery systems (DDSs). It shows excellent biocompatibility, biodegradability, and allows spatio-temporal control release a by altering its chemistry. In spite this, few formulations have reached market. To characterize optimize process, mathematical models offer good alternative as they allow interpreting predicting experimental findings, saving time money. However, there no general model that describes all types polymeric DDSs. This study aims to perform statistical comparison several commonly in order find which them best profile from PLGA particles synthesized nanoprecipitation method. For this purpose, 40 datasets extracted scientific articles published since 2016 were collected. Each set was fitted models: zero fifth polynomials, Korsmeyer-Peppas, Weibull Hyperbolic Tangent Function. Some data sets had observations do not apply statistic test, thus bootstrap resampling technique performed. Statistic evidence showed Function fit data.

Language: Английский

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Recent advances in long-acting drug delivery systems for anticancer drug

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 194, P. 114724 - 114724

Published: Feb. 4, 2023

The use of systemic anticancer chemotherapy is intrinsically limited by its toxicity. Whether dealing with small molecules or biopharmaceuticals, after administration, doses fail to reach effective intratumoral concentrations, while high significant tumor inhibition effects may also drive the death healthy cells, endangering patients. Therefore, strategies based on drug delivery systems (DDSs) for avoiding toxicity have been designed. Due their ability protect drugs from early elimination and control release, DDSs can foster exposure therapeutics extending circulation time steadily releasing into sites. However, approval tailored clinical minimal as safety in vivo activity still need be ameliorated manipulating physicochemical characteristics. During last few years, several described improve safety, stability, fine-tune pharmaceuticals release kinetics. Herein, we reviewed main DDSs, namely polymeric conjugates, nano microparticles, hydrogels, microneedles, explored long-acting treatments, highlighting recently proposed modifications potential advantages different therapies. Additionally, important limitations therapies future technology directions were covered.

Language: Английский

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New insights into water-in-oil-in-water (W/O/W) double emulsions: Properties, fabrication, instability mechanism, and food applications

Trends in Food Science & Technology, Journal Year: 2022, Volume and Issue: 128, P. 22 - 37

Published: Aug. 4, 2022

Language: Английский

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Recent Advancements in Microneedle Technology for Multifaceted Biomedical Applications

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(5), P. 1097 - 1097

Published: May 20, 2022

Microneedle (MNs) technology is a recent advancement in biomedical science across the globe. The current limitations of drug delivery, like poor absorption, low bioavailability, inadequate skin permeation, and biodistribution, can be overcome by MN-based delivery. Nanotechnology made significant changes fabrication techniques for microneedles design shifted from conventional to novel, using various types natural synthetic materials their combinations. Nowadays, MNs has gained popularity worldwide research delivery due its multifaceted broad-spectrum applications. This review broadly discusses MN's types, methods, composition, characterization, applications, advancements, global intellectual scenarios.

Language: Английский

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Micro and nano-carriers-based pulmonary drug delivery system: Their current updates, challenges, and limitations – A review

JCIS Open, Journal Year: 2023, Volume and Issue: 12, P. 100095 - 100095

Published: Sept. 29, 2023

The lung is an attractive target for drug delivery because of the ease non-invasive administration via inhalation, bypassing metabolism in liver, direct to respiratory system treatment diseases, and a large surface area absorption. Nanocarrier systems offer several benefits pulmonary delivery, including uniform distribution among alveoli, improved solubility, sustained release, which reduces dosing frequency enhances patient compliance, potential cell internalization. Nanomedicine also being utilized combat emerging infectious illnesses like SARS-CoV, SARS-CoV-2, MERS-CoV, influenza A/H1N1. This review gives quick rundown diseases caused by agents such as bacterial, viral, biological roadblocks that prevent effective recalcitrant tract infections. We emphasized summarized recent efforts these infections using novel inhaled formulation-mediated strategies nanocarriers liposomes, polymeric nanoparticles, SLNs. In addition, we reviewed latest findings advancements regarding development inhalable formulations circumvent barriers boost bioavailability.

Language: Английский

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