Current Issues in Molecular Biology,
Journal Year:
2023,
Volume and Issue:
45(2), P. 1149 - 1167
Published: Feb. 1, 2023
In
the
field
of
phage
applications
and
clinical
treatment,
virulent
phages
have
been
in
spotlight
whereas
temperate
received,
relatively
speaking,
less
attention.
The
fact
that
often
carry
or
drug-resistant
genes
is
a
constant
concern
drawback
applications.
However,
also
play
role
bacterial
regulation.
This
review
elucidates
biological
properties
based
on
their
life
cycle
introduces
latest
work
applications,
such
as
host
virulence
reduction,
biofilm
degradation,
genetic
engineering
display.
versatile
use
coupled
with
inherent
properties,
economy,
ready
accessibility,
wide
variety
specificity,
make
solid
candidate
tackling
infections.
Cell,
Journal Year:
2023,
Volume and Issue:
186(1), P. 17 - 31
Published: Jan. 1, 2023
Increasing
antimicrobial
resistance
rates
have
revitalized
bacteriophage
(phage)
research,
the
natural
predators
of
bacteria
discovered
over
100
years
ago.
In
order
to
use
phages
therapeutically,
they
should
(1)
preferably
be
lytic,
(2)
kill
bacterial
host
efficiently,
and
(3)
fully
characterized
exclude
side
effects.
Developing
therapeutic
takes
a
coordinated
effort
multiple
stakeholders.
Herein,
we
review
state
art
in
phage
therapy,
covering
biological
mechanisms,
clinical
applications,
remaining
challenges,
future
directions
involving
naturally
occurring
genetically
modified
or
synthetic
phages.
PLoS Biology,
Journal Year:
2023,
Volume and Issue:
21(5), P. e3002119 - e3002119
Published: May 23, 2023
Phage
therapy
is
a
medical
form
of
biological
control
bacterial
infections,
one
that
uses
naturally
occurring
viruses,
called
bacteriophages
or
phages,
as
antibacterial
agents.
Pioneered
over
100
years
ago,
phage
nonetheless
currently
experiencing
resurgence
in
interest,
with
growing
numbers
clinical
case
studies
being
published.
This
renewed
enthusiasm
due
large
part
to
holding
promise
for
providing
safe
and
effective
cures
infections
traditional
antibiotics
acting
alone
have
been
unable
clear.
Essay
introduces
basic
biology,
provides
an
outline
the
long
history
therapy,
highlights
some
advantages
using
phages
agents,
overview
recent
successes.
Although
has
clear
potential,
it
faces
biological,
regulatory,
economic
challenges
its
further
implementation
more
mainstream
acceptance.
International Journal of Clinical Practice,
Journal Year:
2024,
Volume and Issue:
2024, P. 1 - 38
Published: March 9, 2024
The
emergence
of
antibiotic-resistant
strains,
the
decreased
effectiveness
conventional
therapies,
and
side
effects
have
led
researchers
to
seek
a
safer,
more
cost-effective,
patient-friendly,
effective
method
that
does
not
develop
antibiotic
resistance.
With
progress
in
synthetic
biology
genetic
engineering,
genetically
engineered
microorganisms
treatment,
prophylaxis,
drug
delivery,
diagnosis
been
developed.
present
study
reviews
types
bacteria
phages,
their
impacts
on
diseases,
cancer,
metabolic
inflammatory
disorders,
biosynthesis
these
modified
route
administration,
environment.
We
conclude
can
be
considered
promising
candidates
for
adjunctive
treatment
diseases
cancers.
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2024,
Volume and Issue:
14
Published: Jan. 31, 2024
Drug-resistant
Staphylococcus
aureus
stands
as
a
prominent
pathogen
in
nosocomial
and
community-acquired
infections,
capable
of
inciting
various
infections
at
different
sites
patients.
This
includes
bacteremia
(SaB),
which
exhibits
severe
infection
frequently
associated
with
significant
mortality
rate
approximately
25%.
In
the
absence
better
alternative
therapies,
antibiotics
is
still
main
approach
for
treating
infections.
However,
excessive
use
has,
turn,
led
to
an
increase
antimicrobial
resistance.
Hence,
it
imperative
that
new
strategies
are
developed
control
drug-resistant
S.
Bacteriophages
viruses
ability
infect
bacteria.
Bacteriophages,
were
used
treat
bacterial
before
advent
antibiotics,
but
subsequently
replaced
by
due
limited
theoretical
understanding
inefficient
preparation
processes
time.
Recently,
phages
have
attracted
attention
many
researchers
again
because
serious
problem
antibiotic
article
provides
comprehensive
overview
phage
biology,
animal
models,
diverse
clinical
case
treatments,
trials
context
therapy.
It
also
assesses
strengths
limitations
therapy
outlines
future
prospects
research
directions.
review
expected
offer
valuable
insights
engaged
phage-based
treatments
Antibiotics,
Journal Year:
2024,
Volume and Issue:
13(9), P. 870 - 870
Published: Sept. 11, 2024
Phage
therapy,
the
use
of
bacteriophages
(phages)
to
treat
bacterial
infections,
is
regaining
momentum
as
a
promising
weapon
against
rising
threat
multidrug-resistant
(MDR)
bacteria.
This
comprehensive
review
explores
historical
context,
modern
resurgence
phage
and
phage-facilitated
advancements
in
medical
technological
fields.
It
details
mechanisms
action
applications
phages
treating
MDR
particularly
those
associated
with
biofilms
intracellular
pathogens.
The
further
highlights
innovative
uses
vaccine
development,
cancer
gene
delivery
vectors.
Despite
its
targeted
efficient
approach,
therapy
faces
challenges
related
stability,
immune
response,
regulatory
approval.
By
examining
these
areas
detail,
this
underscores
immense
potential
remaining
hurdles
integrating
phage-based
therapies
into
practices.
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(16), P. 8937 - 8937
Published: Aug. 19, 2021
Bacteriophages
are
viruses
infecting
bacterial
cells.
Since
there
is
a
lack
of
specific
receptors
for
bacteriophages
on
eukaryotic
cells,
these
were
long
time
considered
to
be
neutral
animals
and
humans.
However,
studies
recent
years
provided
clear
evidence
that
can
interact
with
significantly
influencing
the
functions
tissues,
organs,
systems
mammals,
including
In
this
review
article,
we
summarize
discuss
discoveries
in
field
interactions
phages
animal
human
organisms.
Possibilities
penetration
into
organs
discussed,
effects
immune
system,
respiratory
central
nervous
gastrointestinal
urinary
tract,
reproductive
system
presented
discussed.
Modulations
cancer
cells
by
indicated.
Direct
indirect
virulent
temperate
We
conclude
organisms
robust,
they
must
taken
under
consideration
when
using
medicine,
especially
phage
therapy,
biotechnological
applications.
Nanotechnology Science and Applications,
Journal Year:
2021,
Volume and Issue:
Volume 14, P. 161 - 177
Published: Sept. 1, 2021
Abstract:
Biofilms
are
bacterial
communities
that
live
in
association
with
biotic
or
abiotic
surfaces
and
enclosed
an
extracellular
polymeric
substance.
Their
formation
on
both
surfaces,
including
human
tissue
medical
device
pose
a
major
threat
causing
chronic
infections.
In
addition,
current
antibiotics
antiseptic
agents
have
shown
limited
ability
to
completely
remove
biofilms.
this
review,
the
authors
provide
overview
of
biofilms
its
characteristics,
burden
evolution
phages.
Moreover,
most
recent
possible
use
phages
phage-derived
enzymes
combat
bacteria
biofilm
structures
is
elucidated.
From
emerging
results,
it
can
be
concluded
despite
successful
products
destroying
biofilms,
they
mostly
not
adequate
eradicate
all
cells.
Nevertheless,
combined
therapy
and/or
other
antimicrobial
antibiotics,
nanoparticles,
peptides
may
effective
approaches
from
treat
their
associated
infections
humans.
Keywords:
substance,
phages,
enzymes,
Biomedicine & Pharmacotherapy,
Journal Year:
2022,
Volume and Issue:
151, P. 113122 - 113122
Published: May 17, 2022
The
Host-microbiome
interactions
that
exist
inside
the
gut
microbiota
operate
in
a
synergistic
and
abnormal
manner.
Additionally,
normal
homeostasis
functioning
of
are
frequently
disrupted
by
intervention
Multi-Drug
Resistant
(MDR)
pathogens.
CRISPR-Cas
(CRISPR-associated
protein
with
clustered
regularly
interspersed
short
palindromic
repeats)
recognized
as
prokaryotic
immune
system
has
emerged
an
effective
genome-editing
tool
to
edit
delete
specific
microbial
genes
for
expulsion
bacteria
through
bactericidal
action.
In
this
review,
we
demonstrate
many
systems
against
anti-microbial
resistance
multiple
pathogens,
which
infiltrate
gastrointestinal
tract.
Moreover,
discuss
advancement
development
phage-delivered
killing
MDR
pathogen.
We
also
combinatorial
approach
use
bacteriophage
delivery
gene
targeting
pathogenic
community
microbiome
resensitize
drug
sensitivity.
Finally,
engineered
phage
plausible
potential
option
improvement
efficacy
system.
Antibiotics,
Journal Year:
2023,
Volume and Issue:
12(8), P. 1329 - 1329
Published: Aug. 17, 2023
The
growing
threat
of
antibiotic
resistance
is
a
significant
global
health
challenge
that
has
intensified
in
recent
years.
burden
on
public
augmented
due
to
its
multifaceted
nature,
as
well
the
slow-paced
and
limited
development
new
antibiotics.
posed
by
now
existential
phage
therapy,
which
had
long
been
touted
promising
replacement
for
Consequently,
it
imperative
explore
potential
combination
therapies
involving
antibiotics
phages
feasible
alternative
treating
infections
with
multidrug-resistant
bacteria.
Although
either
bacteriophage
or
can
potentially
treat
bacterial
infections,
they
are
each
fraught
resistance.
Combination
therapies,
however,
yielded
positive
outcomes
most
cases;
nonetheless,
few
combinations
did
not
show
any
benefit.
comprising
synergistic
activity
other
treatments
such
probiotics
hold
promise
treatment
drug-resistant
infections.
