Phage-tail-like bacteriocins as a biomedical platform to counter anti-microbial resistant pathogens DOI Open Access
Rahul Bhattacharjee, Aditya Nandi, Adrija Sinha

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 155, P. 113720 - 113720

Published: Sept. 23, 2022

Phage Tail Like bacteriocins (PTLBs) has been an area of interest in the last couple years owing to their varied application against multi-drug resistant (MDR), anti-microbial (AMR) pathogens and evolutionary link with dsDNA virus bacteriophages. PTLBs are defective phages derived from Myoviridae Siphoviridae phages, distinguished into R-type (Rigid type) characterized by a non-flexible contractile nanotube resembling phage tails, F-type (Flexible flexible non-contractile rod-like structure similar phages. In this review, we have discussed structural association, mechanism, characterization PTLBs. Moreover, elucidated symbiotic biological function MDR XDR highlighted role The difficulties that must be overcome implement clinically also discussed. It is imperative these issues addressed academics future studies before being implemented clinical settings. This article novel its way as it will not only provide us gateway acts strategy for scholars mitigate control uprising issue AMR but promote development

Language: Английский

The emergence of metal oxide nanoparticles (NPs) as a phytomedicine: A two-facet role in plant growth, nano-toxicity and anti-phyto-microbial activity DOI Open Access
Rahul Bhattacharjee, Lamha Kumar, Nobendu Mukerjee

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 155, P. 113658 - 113658

Published: Sept. 23, 2022

Anti-microbial resistance (AMR) has recently emerged as an area of high interest owing to the rapid surge AMR phenotypes. Metal oxide NPs (MeONPs) have been identified novel phytomedicine and peaked a lot due their potential applications in combating phytopathogens, besides enhancing plant growth yields. Numerous MeONPs (Ti2O, MgO, CuO, Ag2O, SiO2, ZnO, CaO) synthesized tested validate antimicrobial roles without causing toxicity cells. This review discusses application with special emphasis on anti-microbial activities agriculture enlists how cellular caused through reactive oxygen species (ROS) production affects growth, morphology, viability. further highlights two-facet role silver copper including toxicities. Furthermore, factor modulating nanotoxicity immunomodulation for cytokine also discussed. Thus, this article will not only provide researchers bottlenecks but emphasizes comprehensive outline breakthroughs applicability agriculture.

Language: Английский

Citations

83
Nanotheranostics to target antibiotic-resistant bacteria: Strategies and applications DOI Creative Commons
Rahul Bhattacharjee, Arvind Negi,

Basudha Bhattacharya

et al.

OpenNano, Journal Year: 2023, Volume and Issue: 11, P. 100138 - 100138

Published: March 5, 2023

Various health agencies, such as the European Medical Agency (EMA), Centers for Disease Control and Prevention (CDC), World Health Organization (WHO), timely cited upsurge of antibiotic resistance a severe threat to public global economy. Importantly, there is rise in nosocomial infections among covid-19 patients in-hospitalized with delineating disorder. Most are related bacteria residing biofilm, which commonly formed on material surfaces. In biofilms, microcolonies various live syntropy; therefore, their require higher dosage or cocktail broad-spectrum antibiotics, aggravating severity resistance. Notably, lack intrinsic antibacterial properties commercial-grade materials desires develop newer functionalized prevent biofilm formation To devise strategies, prepared at nanoscale demonstrated reasonable enhanced activity antimicrobial agents (that encapsulated/chemically onto surface). this manuscript, we compiled nanosized materials, specifying role targeting specific strains bacteria. We also enlisted examples nanomaterials, nanodevice, nanomachines, nano-camouflaging, nano-antibiotics bactericidal possible clinical implications.

Language: Английский

Citations

43
New Frontiers in CRISPR: Addressing Antimicrobial Resistance with Cas9, Cas12, Cas13, and Cas14 DOI Creative Commons
Ahmed S.A. Ali Agha, Ali Al‐Samydai, Talal Aburjaı

et al.

Heliyon, Journal Year: 2025, Volume and Issue: 11(2), P. e42013 - e42013

Published: Jan. 1, 2025

The issue of antimicrobial resistance (AMR) poses a major challenge to global health, evidenced by alarming mortality predictions and the diminishing efficiency conventional drugs. CRISPR-Cas system has proven be powerful tool in addressing this challenge. It originated from bacterial adaptive immune mechanisms gained significant recognition scientific community. This review aims explore applications technologies combating AMR, evaluating their effectiveness, challenges, potential for integration into current strategies. We conducted comprehensive recent literature databases such as PubMed Web Science, focusing on studies that employ against AMR. offer transformative approach combat with extend beyond traditional Integrating these existing methods could significantly enhance our ability manage potentially reverse growing problem resistance. Future research should address technical ethical barriers facilitate safe effective clinical environmental applications. underscores necessity interdisciplinary collaboration international cooperation harness full fight superbugs.

Language: Английский

Citations

2
The translational paradigm of nanobiomaterials: Biological chemistry to modern applications DOI Creative Commons
Adrija Sinha, Faizan Zarreen Simnani, Dibyangshee Singh

et al.

Materials Today Bio, Journal Year: 2022, Volume and Issue: 17, P. 100463 - 100463

Published: Oct. 17, 2022

Recently nanotechnology has evolved as one of the most revolutionary technologies in world. It now become a multi-trillion-dollar business that covers production physical, chemical, and biological systems at scales ranging from atomic molecular levels to wide range industrial applications, such electronics, medicine, cosmetics. Nanobiomaterials synthesis are promising approaches produced various elements be it plants, bacteria, peptides, nucleic acids, etc. Owing better biocompatibility approach synthesis, they have gained immense attention biomedical field. Moreover, due their scaled-down sized property, nanobiomaterials exhibit remarkable features which make them potential candidate for different domains tissue engineering, materials science, pharmacology, biosensors, Miscellaneous characterization techniques been utilized nanobiomaterials. Currently, commercial transition research level form nano-scaffolds, implants, biosensors is stimulating whole field starting bio-mimetic nacres 3D printing, multiple nanofibers like silk fibers functionalizing drug delivery cancer therapy. The contribution single quantum dot nanoparticles tagging typically discipline genomics proteomics noteworthy. This review focuses on diverse emerging applications mechanistic advancements owing physiochemical properties leading growth industries measures. Alongside implementation several gene approaches, optical coding, photodynamic therapy, vapor sensing elaborately discussed this review. Different parameters based current challenges future perspectives also here.

Language: Английский

Citations

60
The resurgence of phage-based therapy in the era of increasing antibiotic resistance: From research progress to challenges and prospects DOI Creative Commons

Ngozi Joannes Anyaegbunam,

Chijioke Chinedu Anekpo,

Zikora Kizito Glory Anyaegbunam

et al.

Microbiological Research, Journal Year: 2022, Volume and Issue: 264, P. 127155 - 127155

Published: July 30, 2022

Language: Английский

Citations

49
Emerging trends in the nanomedicine applications of functionalized magnetic nanoparticles as novel therapies for acute and chronic diseases DOI Creative Commons
Sabyasachi Dash, Tuhin Das, Paritosh Patel

et al.

Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)

Published: Aug. 31, 2022

Abstract High-quality point-of-care is critical for timely decision of disease diagnosis and healthcare management. In this regard, biosensors have revolutionized the field rapid testing screening, however, are confounded by several technical challenges including material cost, half-life, stability, site-specific targeting, analytes specificity, detection sensitivity that affect overall diagnostic potential therapeutic profile. Despite their advances in testing, very few classical proven effective commercially viable situations emergency recent COVID-19 pandemic. To overcome these functionalized magnetic nanoparticles (MNPs) emerged as key players advancing biomedical sector with promising applications during ongoing crises. This review focus on understanding developments theranostic (MNPs). Given profound global economic health burden, we discuss impact MNPs acute chronic diseases like small RNA therapeutics, vascular diseases, neurological disorders, cancer, well testing. Lastly, culminate a futuristic perspective scope provide an insight into emerging opportunities whose anticipated to disrupt industry. Graphical

Language: Английский

Citations

44
Crosstalk between long noncoding RNA and microRNA in Cancer DOI Creative Commons
Rahul Bhattacharjee, Neeraj Prabhakar, Lamha Kumar

et al.

Cellular Oncology, Journal Year: 2023, Volume and Issue: 46(4), P. 885 - 908

Published: May 28, 2023

miRNAs and lncRNAs play a central role in cancer-associated gene regulations. The dysregulated expression of has been reported as hallmark cancer progression, acting an independent prediction marker for individual patient. interplay miRNA lncRNA decides the variation tumorigenesis that could be mediated by sponges endogenous RNAs, regulating decay, mediating intra-chromosomal interactions, modulating epigenetic components. This paper focuses on influence crosstalk between hallmarks such epithelial-mesenchymal transition, hijacking cell death, metastasis, invasion. Other cellular roles crosstalks, neovascularization, vascular mimicry, angiogenesis were also discussed. Additionally, we reviewed mechanism with specific host immune responses targeting (between miRNA) diagnosis management.

Language: Английский

Citations

36
Deciphering endogenous and exogenous regulations of anammox consortia in responding to lincomycin by multiomics: quorum sensing and CRISPR system DOI

Dong-Qi Huang,

Qian Wu, Jiahui Yang

et al.

Water Research, Journal Year: 2023, Volume and Issue: 239, P. 120061 - 120061

Published: May 15, 2023

Language: Английский

Citations

31
Nanomedicine for drug resistant pathogens and COVID-19 using mushroom nanocomposite inspired with bacteriocin – A review DOI Open Access

Moovendran Srinivash,

Raman Krishnamoorthi,

Pambayan Ulagan Mahalingam

et al.

Inorganic Chemistry Communications, Journal Year: 2023, Volume and Issue: 152, P. 110682 - 110682

Published: April 3, 2023

Language: Английский

Citations

23
CRISPR-Cas System: A Tool to Eliminate Drug-Resistant Gram-Negative Bacteria DOI Creative Commons

Rajeshwari Rajesh Kundar,

Karuna Gokarn

Pharmaceuticals, Journal Year: 2022, Volume and Issue: 15(12), P. 1498 - 1498

Published: Nov. 30, 2022

Rapidly emerging drug-resistant superbugs, especially Gram-negative bacteria, pose a serious threat to healthcare systems all over the globe. Newer strategies are being developed detect and overcome arsenal of weapons that these bacteria possess. The development antibiotics is time-consuming may not provide full proof action on evolving pathogens. clustered regularly interspaced short palindromic repeats/CRISPR-associated protein (CRISPR/Cas) promising in curbing bacteria. This review focuses pathogenesis emergence antimicrobial drug resistance, their treatment failures. It also draws attention present status CRISPR-Cas system diagnosisand bacterial infections.

Language: Английский

Citations

25