Bridging the immunogenicity of a tetravalent dengue vaccine (TAK-003) from children and adolescents to adults

npj Vaccines, Journal Year: 2023, Volume and Issue: 8(1)

Published: May 25, 2023

Immunobridging is an important methodology that can be used to extrapolate vaccine efficacy estimates populations not evaluated in clinical studies, and has been successfully developing many vaccines. Dengue, caused by a mosquito-transmitted flavivirus endemic tropical subtropical regions, traditionally thought of as pediatric disease but now global threat both children adults. We bridged immunogenicity data from phase 3 study tetravalent dengue (TAK-003), performed adolescents living areas, with adults non-endemic areas. Neutralizing antibody responses were comparable studies following receipt two-dose TAK-003 schedule (months 0 3). Similar immune observed across exploratory assessments additional humoral responses. These support the potential for

Language: Английский

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Vaccination in post-tuberculosis lung disease management: A review of the evidence

Pulmonology, Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 1, 2023

Post-tuberculosis lung disease (PTLD), as other chronic respiratory disorders, may have infectious complications; some of them can be prevented with vaccinations. So far, no document has discussed the potential role vaccination in PTLD. Therefore, objective this review was to describe recommendations prevent infections potentially capable complicating A non-systematic literature conducted. The following keywords were used: tuberculosis, vaccination, vaccines and PubMed/MEDLINE Embase used search engine, focusing on English-language only. We identified 9 useful Influenza, pneumococcal anti-COVID-19 vaccinations should recommended. Patients PTLD also benefit from against shingles. Vaccination pertussis is mainly relevant during childhood. Diphtheria, tetanus measles are recommended for general population considered patients not previously vaccinated. Tdap (Tetanus, diphtheria, pertussis) booster repeated every adult ten years. BCG retains its importance early childhood countries where TB endemic. deserves among strategies and/or mitigate complications. Further evidence necessary better understand which greatest impact cost-benefit.

Language: Английский

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Effect of the COVID-19 pandemic on the pediatric infectious disease landscape

European Journal of Pediatrics, Journal Year: 2023, Volume and Issue: 183(3), P. 1001 - 1009

Published: Sept. 20, 2023

Language: Английский

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Umbrella review of the safety of Chikungunya vaccine platforms used in other vaccines

Human Vaccines & Immunotherapeutics, Journal Year: 2025, Volume and Issue: 21(1)

Published: Feb. 11, 2025

Chikungunya virus (CHIKV), transmitted through Aedes mosquitoes, is a significant global health concern. Various vaccine platforms have been explored to combat CHIKV, including formalin inactivation, live-attenuated strains, virus-like particles (VLPs), viral vectors, and mRNA technologies. This umbrella review synthesizes evidence on the safety profiles of used in vaccines that applied other vaccines, focusing adverse events special interest (AESI) pregnant persons, children, adolescents. A comprehensive overview systematic reviews (SRs) was conducted. Results: Seven were included complemented with primary studies. Vaccines like influenza, human papillomavirus (HPV), COVID-19, which share showed no increase AESI. Moderate-to high-quality SRs supported favorable profiles. sharing generally exhibit acceptable

Language: Английский

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Shielding the immunocompromised: COVID-19 prevention strategies for patients with primary and secondary immunodeficiencies

Vaccine, Journal Year: 2025, Volume and Issue: 51, P. 126853 - 126853

Published: Feb. 12, 2025

Language: Английский

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