Cited by Altered resting-state cerebral blood flow and its relationship with molecular architecture in tremor dominant Parkinson’s disease

Association of Early-Onset Psychiatric Disorders with REM Sleep Behavior Disorder – A Retrospective Study DOI

Chengxin Xie,

Aditii Makwana,

Helen S. Driver

et al.

Sleep Medicine, Journal Year: 2025, Volume and Issue: 127, P. 127 - 132

Published: Jan. 18, 2025

Language: Английский

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In silico analysis of hub genes and regulatory networks implicates the putamen in non-motor Parkinson’s disease disorders DOI

Stephen Tunmise Akanbi, Joshua Ayodele Yusuf,

Thompson Oluwaferanmi Ayandele

et al.

Egyptian Journal of Medical Human Genetics, Journal Year: 2025, Volume and Issue: 26(1)

Published: Jan. 20, 2025

Abstract Background Parkinson’s disease (PD) is a neurodegenerative condition marked by the gradual degeneration of dopaminergic neurons in substantia nigra, leading to depletion nigra as well and decreased activity putamen. This study aims identify role putamen non-motor PD symptoms potential therapeutic target PD. Methods Transcriptome profiles (dataset number: GSE205450, obtained from postmortem caudate samples forty controls thirty-five patients) were retrieved Gene Expression Omnibus (GEO) database. Specifically, we focused on data for patients. Differential gene expression analysis was carried out using with Limma, filtering genes |logFC|> 1 (fold change) p < 0.05 ( -value). Protein–Protein Interaction networks constructed stringDB (combined score > 0.7) analyzed Cytoscape hub based various topological measures (EPC, MCC, MNC, Degree, EcCentricity). Enrichment conducted Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG). Also, transcription factor (TF)-hub networks, miRNA-hub association JASPAR database, Tarbase DisGeNET via NetworkAnalyst platform, respectively. Results Seven genes, namely SST , NPY IL6 PVALB ALB NTS TH identified Notable miRNAs included hsa-mir-34a-5p, hsa-mir-15a-5p, hsa-mir-424-5p, hsa-mir-19b-3p while key factors include GATA2, CREB1, FOXC1, FOXL1, TID1, NFKB1, YY1, SPIB, GATA3, STAT3 . Conclusions Our findings revealed close associations between such major depressive disorder, mood disorders schizophrenia. These may provide new direction developing therapy wet lab research encouraged.

Language: Английский

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Prodromal Parkinson’s Disease DOI

Iro Boura, Karolina Popławska-Domaszewicz,

Naomi Limbachiya

et al.

Neurologic Clinics, Journal Year: 2025, Volume and Issue: 43(2), P. 209 - 228

Published: Jan. 22, 2025

Language: Английский

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A reflective account on piloting compassionate skills training for people with Parkinson’s and their care partners DOI

Olivia Batterbee,

Ruth Lewis-Morton

FPOP Bulletin Psychology of Older People, Journal Year: 2025, Volume and Issue: 1(169), P. 47 - 51

Published: Jan. 1, 2025

Informed by the Expert Experience panel within Parkinson’s Disease service at Cardiff and Vale University Health Board, we have developed a pilot Compassionate Skills training, tailored to people newly diagnosed with their care partners. The training incorporates Compassion Focused Therapy (CFT) principles aim of supporting in a) increasing knowledge psychological impact Parkinson’s; b) implementing CFT strategies c) levels self-compassion. found an increase across all knowledge/understanding questions self-compassion ratings from pre-intervention post-intervention. Further research is required support our understanding interventions for (pwP)

Language: Английский

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Altered resting-state cerebral blood flow and its relationship with molecular architecture in tremor dominant Parkinson’s disease DOI

Shangpei Wang,

Yajie Cai,

Sunhong Yan

et al.

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: unknown, P. 111237 - 111237

Published: Jan. 1, 2025

Language: Английский

Citations