Environment International,
Journal Year:
2024,
Volume and Issue:
187, P. 108662 - 108662
Published: April 16, 2024
Potential
effect
of
greenspace
exposure
on
human
microbiota
have
been
explored
by
a
number
observational
and
interventional
studies,
but
the
results
remained
mixed.
We
comprehensively
synthesized
these
studies
performing
systematic
review
following
PRISMA
guidelines.
Comprehensive
literature
searches
in
three
international
databases
(PubMed,
Embase,
Web
Science)
Chinese
(China
National
Knowledge
Infrastructure,
Wanfang,
China
Biology
Medicine
disc)
were
conducted
from
inception
to
November
1,
2023.
Observational
that
evaluated
associations
between
at
different
anatomical
sites
included.
Studies
assessed
using
Toxicology
Program's
office
Health
Assessment
Translation
(OHAT)
risk
bias
tool
certainty
evidence
was
Grading
Recommendations,
Assessment,
Development
Evaluation
(GRADE)
framework.
Two
authors
independently
performed
study
selection,
data
extraction,
assessment,
grading.
Study
descriptively.
Twenty
including
11
9
finally
included
into
review.
The
gut
(n
=
13),
skin
10),
oral
cavity
5),
nasal
5)
eyes
1).
majority
reported
with
increased
diversity
(e.g.,
richness
Shannon
index)
and/or
altered
overall
composition
12)
8),
increases
relative
abundance
probiotics
Ruminococcaceae)
decreases
pathogens
Streptococcus
Escherichia/Shigella).
Due
limited
concerning
oral,
nasal,
ocular
still
inconclusive.
current
suggests
may
diversify
alter
their
healthier
profiles.
These
findings
would
be
helpful
uncovering
potential
mechanisms
underlying
health
promoting
profile
microbiota.
Signal Transduction and Targeted Therapy,
Journal Year:
2022,
Volume and Issue:
7(1)
Published: Sept. 1, 2022
Exercise
training
has
been
widely
recognized
as
a
healthy
lifestyle
well
an
effective
non-drug
therapeutic
strategy
for
cardiovascular
diseases
(CVD).
Functional
and
mechanistic
studies
that
employ
animal
exercise
models
observational
interventional
cohort
with
human
participants,
have
contributed
considerably
in
delineating
the
essential
signaling
pathways
by
which
promotes
fitness
health.
First,
this
review
summarizes
beneficial
impact
of
on
multiple
aspects
We
then
discuss
detail
mediating
exercise's
benefits
The
exercise-regulated
cascades
shown
to
confer
myocardial
protection
drive
systemic
adaptations.
molecules
are
necessary
exercise-induced
physiological
cardiac
hypertrophy
potential
attenuate
injury
reverse
remodeling.
Exercise-regulated
noncoding
RNAs
their
associated
also
discussed
roles
mechanisms
cardioprotective
effects.
Moreover,
we
address
exercise-mediated
can
serve
targets
ranging
from
pharmacological
approaches
gene
therapies
CVD.
factors
influence
effect
highlight
importance
need
further
investigations
regarding
biomarkers
CVD
cross
talk
between
heart
other
tissues
or
organs
during
exercise.
conclude
deep
understanding
involved
health
will
undoubtedly
contribute
identification
development
novel
strategies
World Journal of Gastroenterology,
Journal Year:
2023,
Volume and Issue:
29(28), P. 4368 - 4383
Published: July 26, 2023
The
human
intestine
is
a
natural
environment
ecosystem
of
complex
diversified
and
dynamic
microorganisms,
determined
through
process
competition
selection
during
life.
Those
intestinal
microorganisms
called
microbiota
are
involved
in
variety
mechanisms
the
organism,
they
interact
with
host
therefore
contact
organs
various
systems.
However,
play
crucial
role
maintaining
homeostasis,
also
influencing
its
behaviour.
Thus,
perform
series
biological
functions
important
for
well-being.
provides
nutrients,
simultaneously
drawing
many
benefits
such
as
their
contribution
to
metabolic,
trophic,
immunological,
other
functions.
For
these
reasons
it
has
been
reported
that
quantitative
qualitative
composition
can
protective
or
harmful
on
health.
Therefore,
dysbiosis
lead
an
association
unfavourable
factors
which
dysregulation
physiological
processes
homeostasis.
pre-viously
noted
gut
participate
pathogenesis
autoimmune
diseases,
chronic
inflammation,
diabetes
mellitus,
obesity
atherosclerosis,
neurological
disorders
(e.g.,
autism,
etc.)
colorectal
cancer,
more.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(12), P. 10322 - 10322
Published: June 19, 2023
Several
studies
have
shown
that
the
gut
microbiota
influences
behavior
and,
in
turn,
changes
immune
system
associated
with
symptoms
of
depression
or
anxiety
disorder
may
be
mirrored
by
corresponding
microbiota.
Although
composition/function
intestinal
appears
to
affect
central
nervous
(CNS)
activities
through
multiple
mechanisms,
accurate
epidemiological
evidence
clearly
explains
connection
between
CNS
pathology
and
dysbiosis
is
not
yet
available.
The
enteric
(ENS)
a
separate
branch
autonomic
(ANS)
largest
part
peripheral
(PNS).
It
composed
vast
complex
network
neurons
which
communicate
via
several
neuromodulators
neurotransmitters,
like
those
found
CNS.
Interestingly,
despite
its
tight
connections
both
PNS
ANS,
ENS
also
capable
some
independent
activities.
This
concept,
together
suggested
role
played
microorganisms
metabolome
onset
progression
neurological
(neurodegenerative,
autoimmune)
psychopathological
(depression,
disorders,
autism)
diseases,
large
number
investigations
exploring
functional
physiopathological
implications
microbiota/brain
axis.
BMC Microbiology,
Journal Year:
2023,
Volume and Issue:
23(1)
Published: March 2, 2023
Abstract
Background
Irinotecan
is
a
chemotherapeutic
agent
used
to
treat
variety
of
tumors,
including
colorectal
cancer
(CRC).
In
the
intestine,
it
transformed
into
SN-38
by
gut
microbial
enzymes,
which
responsible
for
its
toxicity
during
excretion.
Objective
Our
study
highlights
impact
on
microbiota
composition
and
role
probiotics
in
limiting
Irinotecan-associated
diarrhea
suppressing
bacterial
β-glucuronidase
enzymes.
Material
methods
To
investigate
effect
composition,
we
applied
16S
rRNA
gene
sequencing
three
groups
stool
samples
from
healthy
individuals,
colon
cancer,
treated
patients
(
n
=
5/group).
Furthermore,
Lactobacillus
spp.;
Lactiplantibacillus
plantarum
(L.
plantarum)
,
acidophilus
acidophilus)
Lacticaseibacillus
rhamnosus
L.
rhamnosus)
were
single
mixed
form
in-vitro
explore
expression
E.
coli
.
Also,
introduced
forms
mice
before
administration
Irinotecan,
their
protective
effects
explored
assessing
level
reactive
oxidative
species
(ROS)
as
well
studying
concomitant
intestinal
inflammation
apoptosis.
Results
The
was
disturbed
individuals
with
after
treatment.
group,
Firmicutes
more
abundant
than
Bacteriodetes,
opposite
case
colon-cancer
or
groups.
Actinobacteria
Verrucomicrobia
markedly
present
within
while
Cyanobacteria
noted
Irinotecan-treated
Enterobacteriaceae
genus
Dialister
group
other
abundance
Veillonella
Clostridium
Butryicicoccus,
Prevotella
increased
compared
Using
spp.
mixture
models
significantly
relieved
Irinotecan-induced
through
reduction
both
ROS,
addition
guarding
epithelium
against
dysbiosis
proliferative
crypt
injury.
Conclusions
Irinotecan-based
chemotherapy
altered
microbiota.
participates
greatly
determining
efficacy
chemotherapies,
caused
ß-glucuronidase
can
now
be
aimed
modulated
promote
decrease
chemotherapeutics.
probiotic
regimen
this
lowered
mucositis,
stress,
cellular
inflammation,
apoptotic
cascade
induction
Irinotecan.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(6), P. 3340 - 3340
Published: March 15, 2024
Psychiatric
disorders
represent
a
primary
source
of
disability
worldwide,
manifesting
as
disturbances
in
individuals’
cognitive
processes,
emotional
regulation,
and
behavioral
patterns.
In
the
quest
to
discover
novel
therapies
expand
boundaries
neuropharmacology,
studies
from
field
have
highlighted
gut
microbiota’s
role
modulating
these
disorders.
These
alterations
may
influence
brain’s
processes
through
brain–gut
axis,
multifaceted
bidirectional
system
that
establishes
connection
between
enteric
central
nervous
systems.
Thus,
probiotic
prebiotic
supplements
are
meant
overall
health
play
an
insightful
alleviating
psychiatric
symptoms,
such
templates
major
depressive
disorder,
anxiety,
or
schizophrenia.
Moreover,
administration
psychotropic
drugs
has
been
revealed
induce
specific
changes
microbiome’s
diversity,
suggesting
their
potential
utility
combating
bacterial
infections.
This
review
emphasizes
intricate
correlations
microbiota,
mentioning
promising
approaches
regard
modulation
treatments,
well
antimicrobial
effects
medication.
Frontiers in Microbiology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 6, 2025
The
NOD-like
receptor
family
pyrin
domain-containing
3
(NLRP3)
is
a
key
pattern
recognition
in
the
innate
immune
system.
Its
overactivation
leads
to
production
of
pro-inflammatory
cytokines,
such
as
IL-1β
and
IL-18,
which
contribute
development
progression
various
diseases.
In
recent
years,
evidence
has
shown
that
gut
microbiota
plays
an
important
role
regulating
activation
NLRP3
inflammasome.
Variations
function
composition
can
directly
or
indirectly
influence
inflammasome
by
influencing
bacterial
components
metabolites.
Additionally,
exercise
been
effectively
reduce
while
promoting
beneficial
changes
microbiota.
This
suggests
may
play
mediating
effects
on
regulation.
review
explores
impact
activation,
examines
mechanisms
through
mediates
anti-inflammatory
exercise,
providing
new
avenues
for
research.
mBio,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 31, 2025
Sepsis-induced
acute
liver
injury
(SALI)
is
a
prevalent
and
life-threatening
complication
associated
with
sepsis.
The
gut
microbiota
plays
crucial
role
in
the
maintenance
of
health
development
diseases.
impact
physical
exercise
on
modulation
has
been
well-documented.
However,
potential
microbiome
training-induced
protection
against
SALI
remains
uncertain.
Here,
we
discovered
training
ameliorated
systemic
inflammation
septic
mice.
Notably,
pre-depletion
abolished
protective
effects
Fecal
transplantation
treatment
revealed
that
training-associated
contributed
to
beneficial
effect
SALI.
Exercise
modulated
metabolism
Ligilactobacillus
enriched
betulinic
acid
(BA)
levels
Functionally,
BA
conferred
by
inhibiting
hepatic
inflammatory
response
bound
inactivated
hnRNPA2B1,
thus
suppressing
NLRP3
inflammasome
activation
macrophages.
Collectively,
this
study
reveals
involved
SALI,
microbiota-derived
inhibits
via
hnRNPA2B1-NLRP3
axis,
providing
therapeutic
strategy
for
Sepsis
characterized
dysregulated
immune
an
infection
leads
multiple
organ
dysfunction.
occurrence
frequently
observed
during
initial
stage
sepsis
directly
linked
mortality
intensive
care
unit.
preventive
well
recognized,
yet
underlying
mechanism
poorly
elucidated.
alters
mice,
increasing
abundance
promoting
generation
BA.
Additionally,
supplementation
can
suppress
macrophages
binding
thereby
mitigating
These
results
highlight
response,
which
represents
stride
toward
implementing
microbiome-based
strategies
clinical
management
Medicine in Microecology,
Journal Year:
2022,
Volume and Issue:
14, P. 100070 - 100070
Published: Nov. 30, 2022
Dietary
fiber
intake
in
humans
is
nowadays
substantially
decreased
as
compared
to
the
communities
of
ancestral
populations.
Accompanying
that,
incidences
inflammatory
bowel
disease
(IBD),
allergy,
and
other
autoimmune
diseases
are
steadily
increasing
over
past
60
years,
especially
high-income
countries,
which
partly
attributed
changing
dietary
habit
modern
societies.
Chronic
inflammation
triggered
by
immune
disorders
central
part
pathophysiology
various
non-communicable
diseases.
inexorably
linked
gut
microbiome
leading
reduction
inflammation.
This
review
explores
how
fibers
modulate
microbiota
composition
function
alteration
host
physiology.
High-fiber
regime
has
been
consistently
shown
increase
alpha
diversity
short-chain
fatty
acids
(SCFAs)-producing
bacteria
human
gut.
SCFAs
main
players
interplay
between
diet,
microbiota,
health.
In
clinical
settings,
therapies
with
high
or
SCFA
supplementations
proposed
for
However,
due
greater
variations
dosage,
type,
duration
intervention
different
trials,
effects
remain
controversial.
Unraveling
mechanisms
exerted
synergy
holds
a
promising
prospect
guiding
next-generation
precision
therapies.
Frontiers in Microbiology,
Journal Year:
2023,
Volume and Issue:
14
Published: July 27, 2023
Diabetic
nephropathy
(DN)
is
a
severe
microvascular
complication
of
diabetes,
which
increases
the
risk
renal
failure
and
causes
high
global
disease
burden.
Due
to
lack
sustainable
treatment,
DN
has
become
primary
cause
end-stage
worldwide.
Gut
microbiota
its
metabolites
exert
critical
regulatory
functions
in
maintaining
host
health
are
associated
with
many
pathogenesis
aging-related
chronic
diseases.
Currently,
theory
gut–kidney
axis
opened
novel
angle
understand
relationship
between
gut
multiple
kidney
In
recent
years,
accumulating
evidence
revealed
that
their
play
an
essential
role
pathophysiologic
processes
through
axis.
this
review,
we
summarize
current
investigations
microbial
involvement
progression
DN,
further
discuss
potential
microbiota-targeted
therapeutic
approaches
for
DN.