Greenspace and human microbiota: A systematic review DOI Creative Commons
Yidan Zhang,

Gang-Long Zhou,

Lu Wang

et al.

Environment International, Journal Year: 2024, Volume and Issue: 187, P. 108662 - 108662

Published: April 16, 2024

Potential effect of greenspace exposure on human microbiota have been explored by a number observational and interventional studies, but the results remained mixed. We comprehensively synthesized these studies performing systematic review following PRISMA guidelines. Comprehensive literature searches in three international databases (PubMed, Embase, Web Science) Chinese (China National Knowledge Infrastructure, Wanfang, China Biology Medicine disc) were conducted from inception to November 1, 2023. Observational that evaluated associations between at different anatomical sites included. Studies assessed using Toxicology Program's office Health Assessment Translation (OHAT) risk bias tool certainty evidence was Grading Recommendations, Assessment, Development Evaluation (GRADE) framework. Two authors independently performed study selection, data extraction, assessment, grading. Study descriptively. Twenty including 11 9 finally included into review. The gut (n = 13), skin 10), oral cavity 5), nasal 5) eyes 1). majority reported with increased diversity (e.g., richness Shannon index) and/or altered overall composition 12) 8), increases relative abundance probiotics Ruminococcaceae) decreases pathogens Streptococcus Escherichia/Shigella). Due limited concerning oral, nasal, ocular still inconclusive. current suggests may diversify alter their healthier profiles. These findings would be helpful uncovering potential mechanisms underlying health promoting profile microbiota.

Language: Английский

Exercise training maintains cardiovascular health: signaling pathways involved and potential therapeutics DOI Creative Commons
Huihua Chen, Chen Chen, Michail Spanos

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: Sept. 1, 2022

Exercise training has been widely recognized as a healthy lifestyle well an effective non-drug therapeutic strategy for cardiovascular diseases (CVD). Functional and mechanistic studies that employ animal exercise models observational interventional cohort with human participants, have contributed considerably in delineating the essential signaling pathways by which promotes fitness health. First, this review summarizes beneficial impact of on multiple aspects We then discuss detail mediating exercise's benefits The exercise-regulated cascades shown to confer myocardial protection drive systemic adaptations. molecules are necessary exercise-induced physiological cardiac hypertrophy potential attenuate injury reverse remodeling. Exercise-regulated noncoding RNAs their associated also discussed roles mechanisms cardioprotective effects. Moreover, we address exercise-mediated can serve targets ranging from pharmacological approaches gene therapies CVD. factors influence effect highlight importance need further investigations regarding biomarkers CVD cross talk between heart other tissues or organs during exercise. conclude deep understanding involved health will undoubtedly contribute identification development novel strategies

Language: Английский

Citations

87
Microbiota revolution: How gut microbes regulate our lives DOI Creative Commons
Marica Colella, Ioannis Alexandros Charitos, Andrea Ballini

et al.

World Journal of Gastroenterology, Journal Year: 2023, Volume and Issue: 29(28), P. 4368 - 4383

Published: July 26, 2023

The human intestine is a natural environment ecosystem of complex diversified and dynamic microorganisms, determined through process competition selection during life. Those intestinal microorganisms called microbiota are involved in variety mechanisms the organism, they interact with host therefore contact organs various systems. However, play crucial role maintaining homeostasis, also influencing its behaviour. Thus, perform series biological functions important for well-being. provides nutrients, simultaneously drawing many benefits such as their contribution to metabolic, trophic, immunological, other functions. For these reasons it has been reported that quantitative qualitative composition can protective or harmful on health. Therefore, dysbiosis lead an association unfavourable factors which dysregulation physiological processes homeostasis. pre-viously noted gut participate pathogenesis autoimmune diseases, chronic inflammation, diabetes mellitus, obesity atherosclerosis, neurological disorders (e.g., autism, etc.) colorectal cancer, more.

Language: Английский

Citations

70
The Crosstalk between Gut Microbiota and Nervous System: A Bidirectional Interaction between Microorganisms and Metabolome DOI Open Access
Monica Montagnani, Lucrezia Bottalico, Maria Assunta Potenza

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(12), P. 10322 - 10322

Published: June 19, 2023

Several studies have shown that the gut microbiota influences behavior and, in turn, changes immune system associated with symptoms of depression or anxiety disorder may be mirrored by corresponding microbiota. Although composition/function intestinal appears to affect central nervous (CNS) activities through multiple mechanisms, accurate epidemiological evidence clearly explains connection between CNS pathology and dysbiosis is not yet available. The enteric (ENS) a separate branch autonomic (ANS) largest part peripheral (PNS). It composed vast complex network neurons which communicate via several neuromodulators neurotransmitters, like those found CNS. Interestingly, despite its tight connections both PNS ANS, ENS also capable some independent activities. This concept, together suggested role played microorganisms metabolome onset progression neurological (neurodegenerative, autoimmune) psychopathological (depression, disorders, autism) diseases, large number investigations exploring functional physiopathological implications microbiota/brain axis.

Language: Английский

Citations

59
Targeting the gut microbiota-related metabolites for osteoporosis: The inextricable connection of gut-bone axis DOI
Yuan‐Wei Zhang, Yan Wu,

Xiang-Fei Liu

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 94, P. 102196 - 102196

Published: Jan. 12, 2024

Language: Английский

Citations

45
Irinotecan-gut microbiota interactions and the capability of probiotics to mitigate Irinotecan-associated toxicity DOI Creative Commons

Marwa S. Mahdy,

Ahmed F. Azmy, Tarek Dishisha

et al.

BMC Microbiology, Journal Year: 2023, Volume and Issue: 23(1)

Published: March 2, 2023

Abstract Background Irinotecan is a chemotherapeutic agent used to treat variety of tumors, including colorectal cancer (CRC). In the intestine, it transformed into SN-38 by gut microbial enzymes, which responsible for its toxicity during excretion. Objective Our study highlights impact on microbiota composition and role probiotics in limiting Irinotecan-associated diarrhea suppressing bacterial β-glucuronidase enzymes. Material methods To investigate effect composition, we applied 16S rRNA gene sequencing three groups stool samples from healthy individuals, colon cancer, treated patients ( n = 5/group). Furthermore, Lactobacillus spp.; Lactiplantibacillus plantarum (L. plantarum) , acidophilus acidophilus) Lacticaseibacillus rhamnosus L. rhamnosus) were single mixed form in-vitro explore expression E. coli . Also, introduced forms mice before administration Irinotecan, their protective effects explored assessing level reactive oxidative species (ROS) as well studying concomitant intestinal inflammation apoptosis. Results The was disturbed individuals with after treatment. group, Firmicutes more abundant than Bacteriodetes, opposite case colon-cancer or groups. Actinobacteria Verrucomicrobia markedly present within while Cyanobacteria noted Irinotecan-treated Enterobacteriaceae genus Dialister group other abundance Veillonella Clostridium Butryicicoccus, Prevotella increased compared Using spp. mixture models significantly relieved Irinotecan-induced through reduction both ROS, addition guarding epithelium against dysbiosis proliferative crypt injury. Conclusions Irinotecan-based chemotherapy altered microbiota. participates greatly determining efficacy chemotherapies, caused ß-glucuronidase can now be aimed modulated promote decrease chemotherapeutics. probiotic regimen this lowered mucositis, stress, cellular inflammation, apoptotic cascade induction Irinotecan.

Language: Английский

Citations

44
Mind, Mood and Microbiota—Gut–Brain Axis in Psychiatric Disorders DOI Open Access
Corneliu Toader,

Nicolaie Dobrin,

Daniel Ovidiu Costea

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3340 - 3340

Published: March 15, 2024

Psychiatric disorders represent a primary source of disability worldwide, manifesting as disturbances in individuals’ cognitive processes, emotional regulation, and behavioral patterns. In the quest to discover novel therapies expand boundaries neuropharmacology, studies from field have highlighted gut microbiota’s role modulating these disorders. These alterations may influence brain’s processes through brain–gut axis, multifaceted bidirectional system that establishes connection between enteric central nervous systems. Thus, probiotic prebiotic supplements are meant overall health play an insightful alleviating psychiatric symptoms, such templates major depressive disorder, anxiety, or schizophrenia. Moreover, administration psychotropic drugs has been revealed induce specific changes microbiome’s diversity, suggesting their potential utility combating bacterial infections. This review emphasizes intricate correlations microbiota, mentioning promising approaches regard modulation treatments, well antimicrobial effects medication.

Language: Английский

Citations

19
Gut microbiota: a novel target for exercise-mediated regulation of NLRP3 inflammasome activation DOI Creative Commons
Jun Chen,

Shaohui Jia,

Xiaoguang Xue

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 6, 2025

The NOD-like receptor family pyrin domain-containing 3 (NLRP3) is a key pattern recognition in the innate immune system. Its overactivation leads to production of pro-inflammatory cytokines, such as IL-1β and IL-18, which contribute development progression various diseases. In recent years, evidence has shown that gut microbiota plays an important role regulating activation NLRP3 inflammasome. Variations function composition can directly or indirectly influence inflammasome by influencing bacterial components metabolites. Additionally, exercise been effectively reduce while promoting beneficial changes microbiota. This suggests may play mediating effects on regulation. review explores impact activation, examines mechanisms through mediates anti-inflammatory exercise, providing new avenues for research.

Language: Английский

Citations

2
Gut microbe-derived betulinic acid alleviates sepsis-induced acute liver injury by inhibiting macrophage NLRP3 inflammasome in mice DOI Creative Commons

Xuheng Tang,

Tao Zeng, Wenyan Deng

et al.

mBio, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Sepsis-induced acute liver injury (SALI) is a prevalent and life-threatening complication associated with sepsis. The gut microbiota plays crucial role in the maintenance of health development diseases. impact physical exercise on modulation has been well-documented. However, potential microbiome training-induced protection against SALI remains uncertain. Here, we discovered training ameliorated systemic inflammation septic mice. Notably, pre-depletion abolished protective effects Fecal transplantation treatment revealed that training-associated contributed to beneficial effect SALI. Exercise modulated metabolism Ligilactobacillus enriched betulinic acid (BA) levels Functionally, BA conferred by inhibiting hepatic inflammatory response bound inactivated hnRNPA2B1, thus suppressing NLRP3 inflammasome activation macrophages. Collectively, this study reveals involved SALI, microbiota-derived inhibits via hnRNPA2B1-NLRP3 axis, providing therapeutic strategy for Sepsis characterized dysregulated immune an infection leads multiple organ dysfunction. occurrence frequently observed during initial stage sepsis directly linked mortality intensive care unit. preventive well recognized, yet underlying mechanism poorly elucidated. alters mice, increasing abundance promoting generation BA. Additionally, supplementation can suppress macrophages binding thereby mitigating These results highlight response, which represents stride toward implementing microbiome-based strategies clinical management

Language: Английский

Citations

2
The gut microbiome: linking dietary fiber to inflammatory diseases DOI Creative Commons
Feng Zhang, Dejun Fan, Jianlin Huang

et al.

Medicine in Microecology, Journal Year: 2022, Volume and Issue: 14, P. 100070 - 100070

Published: Nov. 30, 2022

Dietary fiber intake in humans is nowadays substantially decreased as compared to the communities of ancestral populations. Accompanying that, incidences inflammatory bowel disease (IBD), allergy, and other autoimmune diseases are steadily increasing over past 60 years, especially high-income countries, which partly attributed changing dietary habit modern societies. Chronic inflammation triggered by immune disorders central part pathophysiology various non-communicable diseases. inexorably linked gut microbiome leading reduction inflammation. This review explores how fibers modulate microbiota composition function alteration host physiology. High-fiber regime has been consistently shown increase alpha diversity short-chain fatty acids (SCFAs)-producing bacteria human gut. SCFAs main players interplay between diet, microbiota, health. In clinical settings, therapies with high or SCFA supplementations proposed for However, due greater variations dosage, type, duration intervention different trials, effects remain controversial. Unraveling mechanisms exerted synergy holds a promising prospect guiding next-generation precision therapies.

Language: Английский

Citations

42
The roles of gut microbiota and its metabolites in diabetic nephropathy DOI Creative Commons
Hui Zhao,

Cheng-E Yang,

Tian Liu

et al.

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: July 27, 2023

Diabetic nephropathy (DN) is a severe microvascular complication of diabetes, which increases the risk renal failure and causes high global disease burden. Due to lack sustainable treatment, DN has become primary cause end-stage worldwide. Gut microbiota its metabolites exert critical regulatory functions in maintaining host health are associated with many pathogenesis aging-related chronic diseases. Currently, theory gut–kidney axis opened novel angle understand relationship between gut multiple kidney In recent years, accumulating evidence revealed that their play an essential role pathophysiologic processes through axis. this review, we summarize current investigations microbial involvement progression DN, further discuss potential microbiota-targeted therapeutic approaches for DN.

Language: Английский

Citations

27