The relationship between triglyceride-glucose index and albuminuria in United States adults

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 23, 2023

Triglyceride-glucose (TyG) index is a simple and reliable indicator of metabolic dysfunction. We aimed to investigate possible relationship between TyG albuminuria in the United States adult population.This cross-sectional study was conducted among adults with complete urinary albumin/urinary creatinine (UACR) from 2011-2018 National Health Nutrition Examination Survey (NHANES). The independent (UACR>30mg/g) evaluated. compared insulin resistance represented by homeostatic model assessment (HOMA-IR), syndrome. Subgroup analysis also performed.A total 9872 participants were included this study, average 8.53 ± 0.01. proportion gradually increased increase quartile interval. Elevated independently associated albuminuria, association persisted after additional adjustments for HOMA-IR or dichotomous area under ROC curve (AUC) larger than that log (HOMA-IR). suggested greater concern age<60, overweight/obese, diabetic, syndrome patients.The may be potential epidemiological tool quantify role dysfunction, rather just resistance, population. Further large-scale prospective studies are needed confirm our findings.

Language: Английский

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Association of triglyceride glucose index and triglyceride glucose-body mass index with sudden cardiac arrest in the general population

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: May 18, 2024

Abstract Background Insulin resistance (IR) significantly contributes to cardiovascular disease (CVD) development. Triglyceride glucose (TyG) index and triglyceride glucose-body mass (TyG-BMI) are recognised as convenient proxies for IR. However, their relationship with sudden cardiac arrest (SCA) remains unclear. Methods This prospective cohort analysis included 355,242 UK Biobank participants available TyG TyG-BMI data no history of CVD. Cox proportional risk models assessed the association between index, SCA risk. Additionally, Accelerated Failure Time (AFT) were employed investigate timing onset. The impact dynamic increases in levels on was examined using restricted cubic spline. Results Over a median follow-up period 165.4 months (interquartile range 156.5–174 months), 1,622 cases recorded. Multivariate regression revealed 9% increase per standard deviation (adjusted hazard ratio (aHR) = 1.09, 95% confidence interval (CI) 1.04–1.15) an 14% (aHR 1.14, CI 1.09–1.2). AFT indicated earlier times occurrence increasing quintiles compared lowest quintile (P trend < 0.05). linearly 0.54) non-linearly 0.007) correlated gradual levels, respectively. Sex-stratified analyses showed stronger associations women. Conclusions Higher associated increased onset, particularly

Language: Английский

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Exploring the TyG Index and the Homeostasis Model Assessment of Insulin Resistance as Insulin Resistance Markers: Implications for Fibromyalgia Management and Understanding—A Narrative Review

Diagnostics, Journal Year: 2025, Volume and Issue: 15(4), P. 494 - 494

Published: Feb. 18, 2025

Fibromyalgia (FM) is a chronic musculoskeletal disease with higher prevalence among women. To date, there has been no definitive laboratory or imaging assessment for FM, and hence, the diagnosis criteria FM remained based on subjective of symptoms high overlap other rheumatological disorders. Many patients suffer from metabolic disorders leading to insulin resistance (IR). There have several methods assess IR, which Homeostasis Model Assessment Insulin Resistance (HOMA-IR) triglyceride-glucose (TyG) index used more frequently, latter being available cost-effective. As IR reported various mechanisms, in this review, we sought investigate association between using current evidence. One possible underlying mechanisms might be mitochondrial dysfunction oxidative stress observed conditions its role FM. Studies also shown that indices are compared healthy controls, while HOMA-IR levels were severities Impact Questionnaire-Revised (FIQR) scores. While these findings suggest involvement pathophysiology add value measurement clinical assessment, further large-scale studies needed establish causal them.

Language: Английский

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Indicators of insulin resistance in clinical practice

Hypertension Research, Journal Year: 2024, Volume and Issue: 47(4), P. 978 - 980

Published: Jan. 4, 2024

Language: Английский

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Deciphering the complex interplay of risk factors in type 2 diabetes mellitus: A comprehensive review

Metabolism Open, Journal Year: 2024, Volume and Issue: 22, P. 100287 - 100287

Published: May 19, 2024

The complex and multidimensional landscape of type 2 diabetes mellitus (T2D) is a major global concern. Despite several years extensive research, the precise underlying causes T2D remain elusive, but evidence suggests that it influenced by myriad interconnected risk factors such as epigenetics, genetics, gut microbiome, environmental factors, organelle stress, dietary habits. number influencing pathogenesis increasing day which worsens scenario; meanwhile, interconnections shoot up frame. By gaining deeper insights into contributing we may pave way for development personalized medicine, could unlock more impactful treatment pathways individuals with T2D. This review summarizes state knowledge about pathogenesis, focusing on interplay between various their implications future therapeutic strategies. Understanding these lead to tailored treatments targeting specific inform prevention efforts population level, ultimately improving outcomes reducing its burden globally.

Language: Английский

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Efficacy and safety of tart cherry supplementary citrate mixture on gout patients: a prospective, randomized, controlled study

Arthritis Research & Therapy, Journal Year: 2023, Volume and Issue: 25(1)

Published: Sept. 7, 2023

Low urine pH, which may be mediated by metabolic syndrome (MetS), is common in gout. Tart cherries are shown to improve MetS symptoms and possess anti-inflammatory properties. However, the efficacy of tart cherry supplements on pH has yet studied.This study aimed investigate safety supplementary citrate (TaCCi) mixture serum urate (sUA), C-reactive protein (CRP), gout flares patients initiating urate-lowering therapy (ULT), comparison sodium bicarbonate.A prospective, randomized (1:1:1), open-label, parallel-controlled trial was conducted among 282 men with fasting ≤ 6, who were ULT febuxostat (initially 20 mg daily, escalating 40 daily if ≥ 360 μmol/L). Participants groups taking either bicarbonate, mixture, or TaCCi mixture. All participants followed every 4 weeks until week 12. Urine sUA co-primary outcomes, various biochemical clinical secondary endpoints.Urine increased a similar extent all three groups. SUA levels declined as well, no significant differences observed between At 12, group exhibited greater reduction albumin/creatinine ratio (UACR) compared other two (p < 0.05). experienced fewer than those bicarbonate over period Additionally, had lower CRP level at 12 relative 0.01). Adverse events across groups.The alkalization sUA-lowering resulted improvements UACR CRP, suggests that provide additional benefits for renal protection reduce inflammation gout, particularly when starting ULT.This project registered ChiCTR ( www.chictr.org.cn ), registration number: ChiCTR2100050749.

Language: Английский

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Longitudinal association between DNA methylation and type 2 diabetes: findings from the KORA F4/FF4 study

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 18, 2025

Abstract Background Type 2 diabetes (T2D) has been linked to changes in DNA methylation levels, which can, turn, alter transcriptional activity. However, most studies for epigenome-wide associations between T2D and comes from cross-sectional design. Few large-scale investigations have explored these longitudinally over multiple time-points. Methods In this longitudinal study, we examined data the Cooperative Health Research Region of Augsburg (KORA) F4 FF4 studies, conducted approximately seven years apart. Leucocyte was assessed using Illumina EPIC 450K arrays. Linear mixed-effects models were employed identify significant sites status, as well with fasting plasma glucose (FPG), hemoglobin A1c (HbA1c), homoeostasis model assessment beta cell function (HOMA-B), insulin resistance (HOMA-IR). Interaction effects status follow-up time also examined. Additionally, CpG associated persistent prediabetes or T2D, progression normal tolerance (NGT) T2D. Finally, identified their corresponding gene expression levels. Results A total 3,501 observations 2,556 participants, measured at least once across two visits, included analyses. We 64 including 15 novel known like those thioredoxin-interacting protein ( TXNIP ) ATP-binding cassette sub-family G member 1 ABCG1 genes. Of these, eight exhibited different rates annual change NGT groups, annotated mannosidase alpha class 2a MAN2A2 carnitine palmitoyl transferase CPT1A ). Longitudinal analysis revealed FPG 128 sites, HbA1c 41 HOMA-IR 57 sites. 104 CpG-transcript pairs whole blood, comprising 40 unique 96 transcripts. Conclusions Our study differentially methylated loci through a approach. report demonstrate that is following differences. These findings provide new insights into molecular mechanisms development. Graphical abstract

Language: Английский

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Effects of SGLT2 inhibitors and GLP-1 receptor agonists on glycemic variability, islet cell function, and insulin resistance in patients with type 2 diabetes mellitus and renal cell carcinoma

American Journal of Cancer Research, Journal Year: 2025, Volume and Issue: 15(3), P. 946 - 965

Published: Jan. 1, 2025

This study evaluated the effects of sodium-glucose co-transporter 2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA) on glycemic control, islet cell function, insulin resistance in type diabetes mellitus (T2DM) patients with T1-stage renal carcinoma (RCC). A retrospective cohort 175 was divided into a control group receiving SGLT2i monotherapy (n = 84) an observation combination therapy GLP-1RA 91). Propensity score matching (PSM) employed to balance baseline characteristics, resulting 35 per group. After treatment, showed significant improvements fasting plasma glucose (FPG), 2-hour postprandial (2hPG), glycated hemoglobin (HbA1c) compared (P < 0.001). Islet function markers, including HOMA-IR, also improved significantly Renal such as serum creatinine, blood urea nitrogen, urinary albumin excretion rate, were better 0.05). Multivariate analysis identified older age (OR 7.434, P 0.025), higher BMI 6.812, 0.003), high-fat diet 0.044, 0.005) independent risk factors for resistance. The combined use demonstrated superior efficacy improving variability, sensitivity, highlighting its potential effective strategy managing T2DM RCC.

Language: Английский

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Association Between Coffee Consumption and Glucose Metabolism Markers in Korean Adults

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1484 - 1484

Published: April 28, 2025

Background/Objectives: Studies examining the association between coffee consumption and glucose metabolism markers have reported inconsistent findings, few considered type. We investigated in Korean adults. Methods: A cross-sectional analysis was conducted using data from Korea National Health Nutrition Examination Survey (2019-2021), including 7453 adults aged 19-64 years. Coffee assessed a 24 h dietary recall categorized as black or with sugar and/or cream (non-drinkers, ≤1 cup/day, 2 cups/day, ≥3 cups/day). Multivariable logistic regression models were used to assess associations markers, homeostasis model assessment of insulin resistance (HOMA-IR). Results: The mean age participants 40.6 years (standard error: 0.19). After full adjustment for covariates, women, consuming two more cups per day inversely associated elevated HOMA-IR (2 cups/day: OR = 0.73, 95% CI: 0.56-0.96; 0.66, 0.44-0.99) fasting levels 0.70, 0.54-0.91; 0.64, 0.43-0.93), compared no consumption, showing significant linear trend (p-trend ≤0.01 all cases). By type, women who consumed had lower odds ≤0.02). In men those cream, observed. Conclusions: Our findings indicate that is women.

Language: Английский

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Insulin resistance assessed by estimated glucose disposal rate and the risk of abdominal aortic calcification: findings from a nationwide cohort study

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: May 12, 2025

Purpose The estimated glucose disposal rate (eGDR) serves as a straightforward and noninvasive indicator of insulin resistance (IR). This study aims to explore the association between eGDR risk abdominal aortic calcification (AAC). Methods We utilized data from adult participants (≥40 years old, n=3006) 2013–2014 National Health Nutrition Examination Survey (NHANES) database. AAC was measured by dual-energy X-ray absorptiometry quantified using Kauppila score. Severe (SAAC) defined an score &gt; 6. Logistic regression, restricted cubic spline (RCS), subgroup analysis were used analyze relationship SAAC risk. Results In fully adjusted models, found be negatively associated with (OR=0.86, 95%CI:0.79–0.94, P &lt;0.001). Compared in lowest quantile, those highest quantile exhibited lower (OR=0.47, 95%CI:0.25–0.91, =0.026). RCS indicates nonlinear risk, turning point at 7.05 mg/kg/min. Subgroup showed that more significant women. Conclusions degree IR assessed is shows promise epidemiological tool for evaluating influence on AAC.

Language: Английский

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