Effects on physical activity, physical fitness and well-being in a 36-months randomized controlled study, comparing a multimodal hospital-based intervention programme for primary cardiovascular prevention with usual care

BMC Cardiovascular Disorders, Journal Year: 2024, Volume and Issue: 24(1)

Published: April 25, 2024

Abstract Background Cardiovascular disease is a major cause of mortality and morbidity worldwide, primary prevention efforts are poorly developed in people at high cardiovascular risk. On this background, we performed the Hjerteløftet Study demonstrated that participation over 36 months multimodal programme, significantly reduced validated risk scores. In current substudy aimed to further explore several elements effects following intervention programme. Methods A random sample from original was included for examinations ( n = 255, 40% women), these patients were already randomized an group (IG) 127), or control (CG) 128). We compared changes baseline 36-months follow-up physical activity, cardiorespiratory fitness, psychological well-being (WHO-5), medication use, smoking habits, cardiometabolic factors (blood pressure, lipids, blood glucose, HbA1c, Apolipoprotein A-I, B high-sensitive C-reactive protein). Results Self-reported activity increased with absolute difference mean delta Physical Activity Index score IG CG: 0.90, 95% CI: 0.10 1.70, p 0.028 (ANCOVA). There no corresponding differences fitness. The resulted improvement both groups larger increase CG. WHO-5 5.06, 0.68 9.45, 0.024, 3.28, -0.69 5.25, 0.104 when controlled values use antihypertensive more CG 0.044). Only minor, nonsignificant observed traditional variables. Conclusions Participation programme improved level, but without changing also tended improve well-being, possibly related less medication. Concerning metabolic status, observed, minor may have been concealed by group. Trial registration ClinicalTrials.gov (NCT01741428), 04/12/2012.

Language: Английский

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Resveratrol Effects on Metabolic Syndrome Features: A Systematic Review and Meta-Analysis

Endocrines, Journal Year: 2024, Volume and Issue: 5(2), P. 225 - 243

Published: May 22, 2024

Resveratrol is a natural polyphenol with important anti-inflammatory and antioxidant properties for treating cardiometabolic disorders. Therefore, the present meta-analysis aimed to review investigate oral resveratrol supplementation effects on metabolic syndrome (MetS) components. The bibliographic search was carried out in 2023 following databases: PubMed, Web of Science, Scopus. Studies that investigated MetS parameters were included. Statistical analyses performed using RevMan Software V.5.3. main findings showed significantly decreased systolic diastolic blood pressure while having no significant waist circumference high-density lipoprotein levels. In addition, glucose level subgroup studies reporting change from baseline means, although overall effect not statistically (p = 0.81), triglyceride levels increased after treatment period. conclusion, evidenced potential therapeutic improving some features, especially regarding pressure, reduction; however, results are still borderline sometimes controversial, which might be justified by methodological statistical heterogeneity studies, latter varying 17 57%.

Language: Английский

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Insulin resistance assessed by short insulin tolerance test and its association with obesity and insulin resistance-related parameters in humans: A pilot randomized trial

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(6), P. e0297718 - e0297718

Published: June 21, 2024

The aim of this study was to examine the association insulin resistance (evaluated by short tolerance test [SITT]) with parameters related obesity and resistance. We prospectively recruited controls patients type 2 diabetes mellitus (T2DM), subjected them SITT, calculated K indices intravenous (KITT(iv)) subcutaneous (KITT(sc)). compared KITT(iv) results between volunteers examined its correlation KITT(sc). also obesity, resistance-related parameters, dose required for glycemic control. A total 24 participants (seven 17 T2DM) were studied. mean significantly lower in T2DM than (2.5%±2.1% vs. 4.5%±1.8%). In all participants, correlated homeostasis model assessment (HOMA-IR) values (r = -0.601, p<0.05) but not KITT(sc) (p 0.62). positively serum adiponectin concentration, negatively visceral fat area concentrations tumor necrosis factor-α branched-chain amino acids. T2DM, HOMA-IR Insulin evaluated using values, degree associated biomarkers, such as adiponectin, factor-α, acids, area,

Language: Английский

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Evaluation of Fasting Glucose-Insulin-C-Peptide-Derived Metabolic Indices for Identifying Metabolic Syndrome in Young, Healthy Adults

Nutrients, Journal Year: 2024, Volume and Issue: 16(13), P. 2135 - 2135

Published: July 4, 2024

Metabolic syndrome (MetS) is a condition defined by cluster of symptoms, including excessive adipose tissue, impaired glucose homeostasis, dyslipidemia, and high blood pressure (BP). We aimed to evaluate the correlation between MetS criteria (IDF) fasting glucose-insulin-C-peptide-derived indices in cohort 128 healthy young adults who were 20–35 years old at time this study. measured serum glucose, insulin, C-peptide (CP), HDL-cholesterol, triglycerides, hsCRP; HOMA-IR INS, CP1, CP2, HOMA-BETA, HOMA-BETA CP, QUICKI, disposition index (DI), CP (CPI), 20/C-peptide*glucose. Significant correlations found BMI all HOMA indices, CPI; waist circumferences QUICKI (for both sexes); INS/CP1/CP2, DI, QUICKI; HDL-cholesterol for males females only with triglycerides systolic BP HOMA-BETA; diastolic DI. The cut-off values combined group (females + males) 1.855, 82.250, 0.355; 2.115, 106.370, 0.345 males; 1.805, 71.305, 0.355 females. A stronger was males’ hsCRP. In conclusion, CP-derived do not add significant information, male sex more predisposed MetS.

Language: Английский

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Assessing the Utility of the Metabolic Score for Insulin Resistance (METS-IR) in Evaluating Metabolic Risk Among Individuals Undergoing Master Health Checkups in a Tertiary Care Hospital in South India: A Retrospective Cohort Study

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 26, 2024

Background The metabolic score for insulin resistance (METS-IR) is a neoteric assessing that has been used as non-insulin-based, objectively measured method. It an easily accessible tool can be on large scale to detect in community. Methods We conducted retrospective cohort study explore the utility of this identifying risk those individuals attending master health checkup tertiary care setting. Data were collected from 254 between October and December 2023. Results According univariate regression analysis, METS-IR had strong correlation predicting cardiovascular risks, evidenced by its positive linear association with increase age (β=0.186,

Language: Английский

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