Podcast: Influenza-Associated Complications and the Impact of Vaccination on Public Health DOI Creative Commons
Stefania Maggi, Melissa K. Andrew,

Annemarijn de Boer

et al.

Infectious Diseases and Therapy, Journal Year: 2023, Volume and Issue: 13(3), P. 413 - 420

Published: Nov. 23, 2023

Influenza is primarily considered an acute respiratory infection but can lead to a myriad of medium and long-term sequelae across every major organ system in the body. Increasing awareness, gaining broader understanding its mechanistic pathways, identifying at-risk individuals, determining how better protect them could help minimize impact. The aim this podcast, featuring Dr Stefania Maggi, Annemarijn de Boer, Melissa K. Andrew, outline main influenza complications their impact beyond disease, as well highlighting vaccination tool at our disposal. Both physical cognitive function be affected result infection, notably frailer which turn may loss independence. Observational studies have identified beneficial effects for cardioprotection preventing dementia, more evidence required. In conclusion, cause wide array complications, prevent.Podcast available article.

Language: Английский

Alzheimer’s Amyloid Hypothesis and Antibody Therapy: Melting Glaciers? DOI Open Access
Poul Flemming Høilund‐Carlsen, Abass Alavi, Rudolph J. Castellani

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3892 - 3892

Published: March 31, 2024

The amyloid cascade hypothesis for Alzheimer's disease is still alive, although heavily challenged. Effective anti-amyloid immunotherapy would confirm the hypothesis' claim that protein amyloid-beta cause of disease. Two antibodies, aducanumab and lecanemab, have been approved by U.S. Food Drug Administration, while a third, donanemab, under review. main argument FDA approvals presumed therapy-induced removal cerebral deposits. Lecanemab donanemab are also thought to some statistical delay in determination cognitive decline. However, clinical efficacy less than with conventional treatment, selection amyloid-positive trial patients non-specific amyloid-PET imaging, uncertain amyloids trials cast doubt on this anti-Alzheimer's antibody therapy hence hypothesis, calling more thorough investigation negative impact type brain.

Language: Английский

Citations

14
Associations of infections and vaccines with Alzheimer's disease point to a role of compromised immunity rather than specific pathogen in AD DOI Creative Commons
Svetlana Ukraintseva, Arseniy Yashkin, Igor Akushevich

et al.

Experimental Gerontology, Journal Year: 2024, Volume and Issue: 190, P. 112411 - 112411

Published: April 2, 2024

Diverse pathogens (viral, bacterial, fungal) have been associated with Alzheimer's disease (AD) and related traits in various studies. This suggests that compromised immunity, rather than specific microbes, may play a role AD by increasing an individual's vulnerability to infections, which could contribute neurodegeneration. If true, then vaccines heterologous effects on extending beyond protection against the targeted disease, hold potential for prevention.

Language: Английский

Citations

13
The impact of the Mediterranean diet on immune function in older adults DOI Creative Commons
Fiona Ecarnot, Stefania Maggi

Aging Clinical and Experimental Research, Journal Year: 2024, Volume and Issue: 36(1)

Published: May 23, 2024

Abstract Diet is one of the lifestyle factors that most amenable to intervention, and has a substantial effect on potential for successful aging mitigation risk disease. Good nutrition pillar healthy aging, large body evidence attests benefits Mediterranean diet quality process. The comprises wide range nutrients which, both individually collectively, exert positive effects immunity, in part mediated by gut microbiota. In this article, we review how its beneficial are We certain key components dietary pattern, including vitamins, zinc, selenium, polyphenols. Overall, existing convincingly demonstrates Mediterreanean affects immune health maintaining weight reducing metabolic cardiovascular diseases; inflammation promoting microbiota profile.

Language: Английский

Citations

8
Influenza and Aging: Clinical Manifestations, Complications, and Treatment Approaches in Older Adults DOI

Christian Rosero,

Stefan Gravenstein, Elie Saade

et al.

Drugs & Aging, Journal Year: 2025, Volume and Issue: 42(1), P. 39 - 55

Published: Jan. 1, 2025

Language: Английский

Citations

1
Malignant Brain Aging: The Formidable Link Between Dysregulated Signaling Through Mechanistic Target of Rapamycin Pathways and Alzheimer’s Disease (Type 3 Diabetes) DOI
Suzanne M. de la Monte

Journal of Alzheimer s Disease, Journal Year: 2023, Volume and Issue: 95(4), P. 1301 - 1337

Published: Sept. 12, 2023

Malignant brain aging corresponds to accelerated age-related declines in functions eventually derailing the self-sustaining forces that govern independent vitality. establishes path toward dementing neurodegeneration, including Alzheimer's disease (AD). The full spectrum of AD includes progressive dysfunction neurons, oligodendrocytes, astrocytes, microglia, and microvascular systems, is mechanistically driven by insulin insulin-like growth factor (IGF) deficiencies resistances with accompanying deficits energy balance, increased cellular stress, inflammation, impaired perfusion, mimicking core features diabetes mellitus. underlying pathophysiological derangements result mitochondrial dysfunction, abnormal protein aggregation, oxidative endoplasmic reticulum aberrant autophagy, post-translational modification proteins, all which are signature both dysregulated insulin/IGF-1-mechanistic target rapamycin (mTOR) signaling. This article connects dots from benign malignant neurodegeneration reviewing salient pathologies associated initially adaptive later dysfunctional mTOR signaling brain. Effective therapeutic preventive measures must be two-pronged designed 1) address complex shifting impairments through re-purpose effective anti-diabetes therapeutics brain, 2) minimize impact extrinsic mediators transitions, e.g., inflammatory states, obesity, systemic resistance diseases, repeated bouts general anesthesia, minimizing exposures or implementing neuroprotective measures.

Language: Английский

Citations

13
Association between COVID-19 infection and new-onset dementia in older adults: a systematic review and meta-analysis DOI Creative Commons
Dan Shan,

Congxiyu Wang,

Trevor J. Crawford

et al.

BMC Geriatrics, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 14, 2024

Abstract Background The relationship between COVID-19 infection and a possible increased likelihood of older adults developing new-onset dementia (NOD) remains elusive. Methods A thorough search was performed across several databases including MEDLINE/PubMed, PsycINFO, Scopus, medRxiv, PQDT Global for studies published in English from January 2020 to December 2023. Only original investigations exploring the link NOD were selected inclusion. We assessed risk NOD, using Risk Ratio (RR) measurement. Control groups categorized as: (i) non-COVID cohort with other respiratory infections [control group (C1)]; (ii) otherwise unspecified health status (C2)]. Follow-up periods divided into intervals 3, 6, 12, 24 months post-COVID. Results 11 (involving 939,824 post-COVID-19 survivors 6,765,117 controls) included review. Across median observation period 12 post-COVID, overall incidence about 1.82% COVID-infected group, compared 0.35% non-COVID-infected group. pooled meta-analysis showed significantly among adult non-COVID-19 controls (RR = 1.58, 95% CI 1.21–2.08). Similar risks observed subgroup analyses restricted an observational 1.56, 1.21–2.01), as well five that employed propensity score matching sufficiently effectively control multiple confounding covariates 1.46, 1.10–1.94). C1 shared comparably (overall RR 1.13, 0.92–1.38). Discussion Under normal circumstances, we believe is likely be factor over time. While due appears similar associated infections, it warrants necessitates investigation longer observations.

Language: Английский

Citations

5
MRI detects blood-brain barrier alterations in a rat model of Alzheimer’s disease and lung infection DOI Creative Commons
Yolanda Ohene, William J. Harris, Elizabeth Powell

et al.

npj Imaging, Journal Year: 2025, Volume and Issue: 3(1)

Published: March 4, 2025

Pneumonia is a common infection in people suffering with Alzheimer's disease, leading to delirium, critical illness or severe neurological decline, which may be due an amplified response of the blood-brain barrier (BBB) peripheral insult. We assess BBB repeated Streptococcus pneumoniae lung rat model disease (TgF344-AD), at 13- and 18-months old, using dynamic contrast-enhanced (DCE) MRI filter exchange imaging. Higher water rate initially detected infected TgF344-AD rats. rates correlated hippocampus aquaporin-4 channel expression animals. no differences permeability gadolinium contrast agent measured by DCE-MRI, confirmed staining for tight junction proteins, occludin claudin-5. These findings provide insight into mechanisms how inflammation impacts BBB.

Language: Английский

Citations

0
SARS-CoV-2 amyloid, is COVID-19-exacerbated dementia an amyloid disorder in the making? DOI Creative Commons
Nathaniel G.N. Milton

Frontiers in Dementia, Journal Year: 2023, Volume and Issue: 2

Published: July 6, 2023

OPINION article Front. Dement., 06 July 2023Sec. Cellular and Molecular Mechanisms of Dementia Volume 2 - 2023 | https://doi.org/10.3389/frdem.2023.1233340

Language: Английский

Citations

8
A review of the roles of pathogens in Alzheimer’s disease DOI Creative Commons
Meng Zhao, Yongchun Wang, Yanxin Shen

et al.

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Aug. 19, 2024

Alzheimer’s disease (AD) is one of the leading causes dementia and characterized by memory loss, mental behavioral abnormalities, impaired ability to perform daily activities. Even as a global that threatens human health, effective treatments slow progression AD have not been found, despite intensive research significant investment. In recent years, role infections in etiology has sparked intense debate. Pathogens invade central nervous system through damaged blood–brain barrier or nerve trunk disrupt neuronal structure function well homeostasis brain microenvironment series molecular biological events. this review, we summarize various pathogens involved pathology, discuss potential interactions between AD, provide an overview promising future anti-pathogenic therapies for AD.

Language: Английский

Citations

1
Detection and management of suspected infections in people with dementia – a scoping review of current practices DOI Creative Commons

Mihaela Ivosevic,

Gritt Overbeck, Anne Holm

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 102520 - 102520

Published: Sept. 1, 2024

Language: Английский

Citations

1