Per- and poly-fluoroalkyl substances (PFAS) and female reproductive outcomes: PFAS elimination, endocrine-mediated effects, and disease

Toxicology, Journal Year: 2021, Volume and Issue: 465, P. 153031 - 153031

Published: Nov. 10, 2021

Per- and poly-fluoroalkyl substances (PFAS) are widespread environmental contaminants frequently detected in drinking water supplies worldwide that have been linked to a variety of adverse reproductive health outcomes women. Compared men, effects women generally understudied while global trends female reproduction rates declining. Many factors may contribute the observed decline reproduction, one which is contaminant exposure. PFAS used home, food storage, personal care industrial products for decades. Despite phase-out some legacy due their persistence effects, alternative, short-chain mixtures will continue pollute air adversely influence women's health. Studies shown both long- disrupt normal function through altering hormone secretion, menstrual cyclicity, fertility. Here, we summarize role tract dysfunction disease. Since these chemicals affect tissues directly or indirectly endocrine disruption, breast, thyroid, hypothalamic-pituitary-gonadal axis also discussed as interplay between be critical understanding long-term A major research gap need mechanism action data - targets systems not evident, but many. Given fecundity ability negatively impact health, further studies needed examine on target involved onset disorders

Language: Английский

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Health-related toxicity of emerging per- and polyfluoroalkyl substances: Comparison to legacy PFOS and PFOA

Environmental Research, Journal Year: 2022, Volume and Issue: 212, P. 113431 - 113431

Published: May 13, 2022

Language: Английский

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Per- and polyfluoroalkyl substance (PFAS) exposure, maternal metabolomic perturbation, and fetal growth in African American women: A meet-in-the-middle approach

Environment International, Journal Year: 2021, Volume and Issue: 158, P. 106964 - 106964

Published: Nov. 1, 2021

Prenatal exposures to per- and polyfluoroalkyl substances (PFAS) have been linked reduced fetal growth. However, the detailed molecular mechanisms remain largely unknown. This study aims investigate biological pathways intermediate biomarkers underlying association between serum PFAS growth using high-resolution metabolomics in a cohort of pregnant African American women Atlanta area, Georgia.Serum perfluorohexane sulfonic acid (PFHxS), perfluorooctane (PFOS), perfluorooctanoic (PFOA), perfluorononanoic (PFNA) measurements untargeted profiling were conducted 313 at 8-14 weeks gestation. Multiple linear regression models applied assess associations with birth weight small-for-gestational age (SGA) birth. A workflow including metabolome-wide study, pathway enrichment analysis, chemical annotation confirmation meet-in-the-middle approach was performed characterize PFAS-fetal relationship.Each log2-unit increase PFNA concentration significantly associated higher odds SGA (OR = 1.32, 95% CI 1.07, 1.63); similar but borderline significant found PFOA 1.20, 0.94, 1.49) SGA. Among 25,516 metabolic features extracted from samples, we successfully annotated confirmed 10 overlapping metabolites both endpoints, glycine, taurine, uric acid, ferulic 2-hexyl-3-phenyl-2-propenal, unsaturated fatty C18:1, androgenic hormone conjugate, parent bile acid-glycine conjugate. Also, identified 21 analyses. These closely related amino lipid metabolism perturbations.In this women, concentrations Perturbations involved growth, shown be potential biomarker. Our results provide opportunities for future studies develop early detection intervention PFAS-induced restriction.

Language: Английский

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Environmental and health impacts of PFAS: Sources, distribution and sustainable management in North Carolina (USA)

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 878, P. 163123 - 163123

Published: March 29, 2023

Language: Английский

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Concentrations of per- and polyfluoroalkyl substances (PFAS) in human placental tissues and associations with birth outcomes

Chemosphere, Journal Year: 2022, Volume and Issue: 295, P. 133873 - 133873

Published: Feb. 7, 2022

Language: Английский

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Adsorption, Structure, and Dynamics of Short- and Long-Chain PFAS Molecules in Kaolinite: Molecular-Level Insights

Environmental Science & Technology, Journal Year: 2022, Volume and Issue: 56(12), P. 8043 - 8052

Published: May 11, 2022

The ubiquitous presence of poly- and perfluoroalkyl substances (PFAS) in different natural settings poses a serious threat to environmental human health. Soils sediments represent one the important exposure pathways PFAS for humans animals. With increasing bioaccumulation mobility, it is extremely understand interactions molecules with dominant constituents soils such as clay minerals. This study reports first time fundamental molecular-level insights into adsorption, interfacial structure, dynamics short- long-chain at water-saturated mesopores kaolinite using classical molecular (MD) simulations. At conditions, all are exclusively adsorbed near hydroxyl surface kaolinite, irrespective terminal functional groups metal cations. adsorption structures coordination environments strongly dependent on nature their hydrophobic chain length. formation large, aggregated clusters responsible restricted comparison short-chain molecules. Such comprehensive knowledge mineral interface critical developing novel site-specific degradation mitigation strategies.

Language: Английский

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Treatment technologies for removal of per- and polyfluoroalkyl substances (PFAS) in biosolids

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 453, P. 139964 - 139964

Published: Oct. 22, 2022

Language: Английский

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Birth Outcomes in Relation to Prenatal Exposure to Per- and Polyfluoroalkyl Substances and Stress in the Environmental Influences on Child Health Outcomes (ECHO) Program

Environmental Health Perspectives, Journal Year: 2023, Volume and Issue: 131(3)

Published: March 1, 2023

Background: Per- and polyfluoroalkyl substances (PFAS) are persistent ubiquitous chemicals associated with risk of adverse birth outcomes. Results previous studies have been inconsistent. Associations between PFAS outcomes may be affected by psychosocial stress. Objectives: We estimated in relation to prenatal concentrations evaluate whether maternal stress modifies those relationships. Methods: included 3,339 participants from 11 prospective cohorts the Environmental influences on Child Health Outcomes (ECHO) program estimate associations five stratified perceived scale scores examine effect modification used Bayesian Weighted Sums mixtures PFAS. Results: observed reduced size increased all For a 1-unit higher log-normalized exposure perfluorooctanoic acid (PFOA), perfluorooctanesulfonic (PFOS), perfluorononanoic (PFNA), perfluorohexane sulfonic (PFHxS), we lower birthweight-for-gestational-age z-scores β=−0.15 [95% confidence interval (CI): −0.27, −0.03], β=−0.14 (95% CI: −0.28, −0.002), β=−0.22 −0.23, −0.10), β=−0.06 −0.18, 0.06), β=−0.25 −0.37, −0.14), respectively. odds ratio (OR) for large-for-gestational-age: ORPFNA=0.56 0.38, 0.83), ORPFDA=0.52 0.35, 0.77). increase concentration summed PFAS, z-score [−0.28; 95% highest posterior density (HPD): −0.44, −0.14] decreased large-for-gestational-age (OR=0.49; HPD: 0.29, 0.82). Perfluorodecanoic (PFDA) explained percentage (40%) both models. were not modified Discussion: Our large, multi-cohort study found negative association birthweight-for-gestational-age, different groups high vs. low This can help inform policy reduce exposures environment humans. https://doi.org/10.1289/EHP10723

Language: Английский

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Newborn metabolomic signatures of maternal per- and polyfluoroalkyl substance exposure and reduced length of gestation

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: May 30, 2023

Abstract Marginalized populations experience disproportionate rates of preterm birth and early term birth. Exposure to per- polyfluoroalkyl substances (PFAS) has been reported reduce length gestation, but the underlying mechanisms are unknown. In present study, we characterized molecular signatures prenatal PFAS exposure gestational age at outcomes in newborn dried blood spot metabolome among 267 African American dyads Atlanta, Georgia between 2016 2020. Pregnant people with higher serum perfluorooctanoic acid perfluorohexane sulfonic concentrations had increased odds an After false discovery rate correction, effect on reduced gestation was associated 8 metabolomic pathways 52 metabolites spots, which suggested perturbed tissue neogenesis, neuroendocrine function, redox homeostasis. These explain how gives rise leading cause infant death United States.

Language: Английский

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Per- and polyfluoroalkyl substances (PFASs) in Chinese surface water: Temporal trends and geographical distribution

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 915, P. 170127 - 170127

Published: Jan. 17, 2024

Language: Английский

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