Journal of Clinical Medicine,
Journal Year:
2024,
Volume and Issue:
13(15), P. 4399 - 4399
Published: July 27, 2024
Objectives:
Evaluate
the
prevalence
of
genetic
factors
in
a
large
population
infertile
subjects
and
define
seminological,
hormonal,
ultrasonographic
features
for
each
alteration.
Methods:
This
single-center
retrospective
study
included
male
partners
couples
undergoing
investigations
due
to
oligozoospermia
or
azoospermia
evaluated
from
January
2012
2022.
The
consist
karyotype,
CFTR
gene
mutations
plus
variant
IVS8-5T
polymorphic
trait,
Y
chromosome
microdeletion,
Next
Generation
Sequencing
panel
analyze
genes
implicated
congenital
hypogonadotropic
hypogonadism
(CHH).
Results:
Overall,
15.4%
(72/466)
patients
received
diagnosis
cause
infertility.
Specifically,
23
(31.9%)
harbor
gene,
22
(30.6%)
have
47,
XXY
14
(19.4%)
show
7
(9.7%)
structural
chromosomal
anomalies,
6
(8.3%)
CHH.
80.6%
were
azoospermic
19.4%
oligozoospermic
(sperm
concentration
3.5
±
3.8
million/mL).
Almost
all
presented
hormonal
alterations
related
specific
genotype,
while
main
ultrasound
testicular
hypoplasia,
calcifications/microcalcifications,
enlarged/hyperechoic
epididymis.
Conclusions:
abnormalities
males
was
our
Center.
disease-causing
variants
resulted
more
frequent,
with
various
clinical
features,
highlighting
complexity
heterogeneity
presentation.
Other
are
needed
understand
if
conditions
like
ring
chromosomes
other
translocations
infertility
incidental
factors.
Current Issues in Molecular Biology,
Journal Year:
2025,
Volume and Issue:
47(2), P. 101 - 101
Published: Feb. 6, 2025
Zinc
plays
a
crucial
role
in
spermatogenesis,
sperm
function,
and
fertilisation.
homeostasis
is
regulated
by
ZIP
ZnT
transporter
proteins,
which
mediate
Zn2+
influx
efflux
across
cell
membranes.
This
study
analysed
total
Zn
concentration
seminal
plasma
serum
of
10
normozoospermic
32
teratozoospermic
men
involved
the
process
infertility
treatment,
using
inductively
coupled
mass
spectrometry.
In
addition,
expression
transporters
ZIP6
ZIP14
two
was
immunofluorescence.
Applying
Student’s
t
test
Mann–Whitney
U
test,
we
found
no
significant
differences
concentrations
between
groups.
mainly
localised
head,
with
slightly
higher
immunopositivity
than
samples,
but
there
statistically
difference
some
samples
showed
tail,
although
were
samples.
The
results
suggest
that
serum,
ZIP14,
do
not
differ
normo-
teratozospermic
emphasise
complex
interplay
factors
underlying
male
fertility.
Reproductive BioMedicine Online,
Journal Year:
2023,
Volume and Issue:
48(4), P. 103647 - 103647
Published: Oct. 29, 2023
Can
a
novel
classification
system
of
the
infertile
male
-
'APHRODITE'
(Addressing
Patients
with
Hypogonadism
and/or
infeRtility
Owing
to
altereD,
Idiopathic
TEsticular
function)
stratify
different
subgroups
infertility
help
scientists
design
clinical
trials
on
hormonal
treatment
infertility,
and
clinicians
counsel
treat
endocrinological
imbalances
in
men
and,
ultimately,
increase
chances
natural
assisted
conception?
Reproductive Biology and Endocrinology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Jan. 5, 2024
Abstract
In
Italy
the
fertility
rate
is
very
low,
and
an
increasing
number
of
patients
are
infertile
require
treatments.
The
Italian
Law
concerning
safety
patient
care,
professional
liability
health
professionals,
indicates
that
professionals
must
comply
with
recommendations
set
out
in
guidelines
developed
by
public
private
bodies
institutions,
as
well
scientific
societies
technical-scientific
associations
professions,
except
for
specific
cases.
Unfortunately,
no
guideline
diagnosis
management
infertility
currently
available
Italy.
2019,
Society
Human
Reproduction
pointed
need
to
produce
subsequently
approved
establishment
a
multidisciplinary
multiprofessional
working
group
(MMWG)
develop
such
guideline.
MMWG
was
representative
5
societies,
one
national
federation
orders,
3
citizens'
patients'
associations,
professions
(including
lawyer,
biologist,
doctor,
midwife,
psychologist),
medical
specialties
genetics,
obstetrics
gynecology,
urology).
chose
adapt
high-quality
context
instead
developing
from
scratch.
Using
version
Appraisal
Guidelines
Research
Evaluation
II
scoring
system,
National
Institute
Clinical
Excellence
were
selected
adapted
context.
document
improved
upon
incorporating
comments
suggestions
where
needed.
This
study
presents
process
adaptation
discusses
pros
cons
often-neglected
choice
adapting
rather
than
new
guidelines.
Journal of Personalized Medicine,
Journal Year:
2024,
Volume and Issue:
14(7), P. 726 - 726
Published: July 4, 2024
Male
infertility
accounts
for
approximately
40%
of
cases.
There
are
many
causes
male
infertility,
including
environmental
factors,
age,
lifestyle,
infections,
varicocele,
and
cancerous
pathologies.
Severe
oligozoospermia,
cryptozoospermia,
azoospermia
(obstructive
non-obstructive)
identified
as
severe
factor
once
considered
conditions
sterility.
Today,
in
vitro
fertilization
(IVF)
techniques
the
only
treatment
strategy
cases
which
new
methodologies
have
been
developed
manipulation
spermatozoa
to
achieve
increase
success
rates.
This
review
is
an
update
techniques,
particular
sperm
selection,
emphasizing
clinical
case-specific
methodology.
The
IVF
process
related
diagnosis,
appropriate
choice
treatment,
effective
preparation
selection.
In
fact,
selecting
best
guarantee
optimal
paternal
heritage
means
increasing
blastulation,
implantation,
ongoing
pregnancy
live
birth
rates,
resulting
greater
techniques.
IntechOpen eBooks,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 4, 2025
A
variety
of
techniques
have
been
employed
in
the
field
sperm
selection,
including
methods
based
on
density,
morphological
characteristics,
motility
membrane
integrity,
and
surface
charge.
Among
these
techniques,
density
gradient
centrifugation
(DGC)
method
stands
out
as
most
prevalent
widely
utilized
today.
However,
this
technique
involves
steps
that
linked
to
oxidative
stress
subsequent
cellular
damage.
Consequently,
alternatives
DGC
are
being
continuously
developed.
The
recently
developed
microfluidic
chip
has
also
implemented
for
selection
intracytoplasmic
injection
(ICSI).
presents
certain
disadvantages
must
be
addressed.
This
chapter
evaluates
advantages
from
past
present,
with
a
particular
focus
devices.
Frontiers in Reproductive Health,
Journal Year:
2025,
Volume and Issue:
7
Published: March 7, 2025
Objective
To
report
a
case
of
patient
who,
after
experiencing
recurrent
failed
implantations,
underwent
novel
technological
intervention—using
the
Q300
device—which
successfully
led
to
pregnancy
and
delivery
healthy
baby.
Design
Case
report.
Setting
Barzilai
University
Medical
Center.
Patient
(s)
A
33-year-old
woman
with
primary
infertility
experienced
implantation
failure
(RIF),
while
her
32-year-old
male
partner
was
diagnosed
severe
oligo-astheno-teratozoospermia
(OTA)
syndrome.
Intervention
Using
device
for
selection
morphologically
compliant
sperm
cells
intracytoplasmic
injection
(ICSI).
Main
outcome
measures
Successful
delivery.
Results
unique
clinical
involving
couple
facing
RIF
OTA.
In
this
case,
new
technology
used.
The
semen
sample
examined
using
choose
WHO2021-morphologically
micro-injection.
resulting
embryos
were
developed
then
frozen.
Later,
frozen-thawed
embryo
transfer
performed
during
following
natural
menstrual
cycle,
leading
successful
Conclusion
utilization
3D
imaging
underscores
evolving
landscape
reproductive
medicine
potential
it
holds
transforming
outcomes
in
challenging
cases.
By
documenting
such
cases,
we
contribute
ongoing
dialogue
refine
assisted
(ART)
protocols
improve
individuals
similar
challenges.
Trial
registration
NCT06232720
https://clinicaltrials.gov/study/NCT06232720
.
Date
registration:
15
Feb
2023.
enrollment
first
subject:
20
August
Journal of Obstetrics and Gynaecology Research,
Journal Year:
2025,
Volume and Issue:
51(4)
Published: April 1, 2025
MiRNAs
regulate
gene
expression,
impacting
reproductive
health,
such
as
infertility
and
implantation
failure.
This
study
investigated
the
association
between
miRNA
polymorphisms
male
(azoospermia,
oligospermia),
female
(endometriosis),
recurrent
failure
in
IVF.
In
order
to
find
relevant
articles,
a
search
was
conducted
PubMed,
WOS,
Scopus,
Cochrane
Library
databases
using
Mesh
terms
Entry
with
keywords
(miRNA
OR
microRNA
polymorphism)
AND
(abortion
miscarriage
sterility
pregnancy
loss
failure).
The
revealed
linked
higher
risk
of
repeated
These
results
underscore
significance
genetic
variations
miRNAs
developing
issues
promise
personalized
treatment
strategies
guided
by
profiles.
provide
valuable
insights
into
basis
emphasize
need
for
further
research
develop
targeted
diagnostic
tools
therapies.
Understanding
role
health
has
significant
implications
improving
outcomes
couples
struggling
infertility.
By
elucidating
factors
contributing
infertility,
this
paves
way
approaches
diagnosis
treatment,
ultimately
enhancing
care.
View,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 9, 2025
Abstract
Infertility
is
a
global
issue,
with
male
factors
contributing
to
approximately
50%
of
cases.
While
assisted
reproductive
technologies
(ART)
resolve
30%–50%
cases,
2%–5%
IVF
failures
require
rescue
intracytoplasmic
sperm
injection
(RICSI).
Sperm
glycocalyx
critical
for
capacitation
and
fertilization,
sperm‐derived
exosomes,
essential
cell
communication,
remain
underexplored.
This
study
used
lectin
microarrays
fluorescence
histochemistry
analyze
glycopatterns
in
exosomes
from
RICSI
groups,
assessed
motility
glycan
expression
after
exposure
IVF‐derived
exosomes.
Clinical
data
2023
at
Northwest
Women
Children's
Hospital,
China,
showed
that
couples
had
longer
infertility
durations,
younger
ages,
required
lower
gonadotropin
doses,
retrieved
more
oocytes,
despite
quality.
However,
pregnancy
rates
were
similar
between
groups.
Glycopattern
analysis
revealed
αGalNAc,
Tn
antigen,
GalNAcα1‐3(Fucα1‐2)Gal
(DBA‐recognized)
glycans
downregulated
sperm,
while
Galβ1‐3GalNAcα‐Ser/Thr
(T),
GalNAcα‐Ser/Thr
(Tn),
sialyl‐T
(Jacalin‐recognized)
upregulated
compared
IVF.
Exosomes
higher
PHA‐L‐,
SBA‐,
UEA‐I‐bound
glycans,
but
AAL‐bound
than
sperm.
DBA
primarily
bound
the
neck,
acrosomal
region,
plasma
membrane,
tail
its
binding
was
significantly
reduced
Functionally,
enhanced
dose‐dependent
manner
by
upregulating
DBA‐recognized
glycans.
These
findings
provide
insights
into
biomarkers,
optimization,
glycosylation's
role
exosome‐related
infertility,
suggesting
exosome‐based
therapy
improving
motility.
