Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown
Published: May 26, 2025
Language: Английский
Circulation Research, Journal Year: 2024, Volume and Issue: 134(9), P. 1136 - 1159
Published: April 25, 2024
Conservative estimates by the World Health Organization suggest that at least a quarter of global cardiovascular diseases are attributable to environmental exposures. Associations between air pollution and risk have garnered most headlines strong, but less attention has been paid other omnipresent toxicants in our ecosystem. Perfluoroalkyl polyfluoroalkyl substances (PFASs) man-made chemicals extensively used industrial consumer products worldwide aqueous film-forming foam utilized firefighting. As such, exposure PFAS is essentially ubiquitous. Given long half-lives these degradation-resistant chemicals, virtually, all people carrying body burden PFAS. concerns related growing such National Academies Sciences, Engineering Medicine recommended standards for clinical follow-up individuals with high blood levels, including prioritizing screening dyslipidemia. The link dyslipidemia investigated, evidence associations compelling. However, not only factor which associated. Here, we review epidemiological links concern identified factors disease, overweight/obesity, glucose intolerance, hypertension, dyslipidemia, hyperuricemia. Moreover, potential connections vascular disease atherosclerosis. While observational data support selected cardiac factors, additional research needed establish causation better understand how leads development conditions.
Language: Английский
Citations
26
Gut, Journal Year: 2024, Volume and Issue: unknown, P. gutjnl - 332523
Published: Aug. 23, 2024
Epidemiological and translational data increasingly implicate environmental pollutants in inflammatory bowel disease (IBD). Indeed, the global incidence of IBD has been rising, particularly developing countries, parallel with increased use chemicals synthetic materials daily life escalating pollution levels. Recent nationwide ecological studies have reported associations between agricultural pesticides IBD, Crohn’s disease. Exposure to other chemical categories also linked an risk IBD. To synthesise available identify knowledge gaps, we conducted a systematic review human that on impact outcomes. Furthermore, summarised vitro animal investigating mechanisms underlying these associations. The 32 included corroborate heavy transition metals, except zinc, air pollutants, per- polyfluorinated substances, are associated exposure being disease-related adverse outcomes as well. narrative preclinical suggests several overlapping associations, including intestinal permeability, systemic inflammation dysbiosis. A consolidated understanding exposures is key identification potentially modifiable factors inform strategies towards prediction, prevention mitigation
Language: Английский
Citations
13
Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(5), P. 2214 - 2223
Published: Jan. 24, 2024
The composition of human breast milk (HBM) exhibits significant variability both between individuals and within the same individual. While environmental factors are believed to play a role in this variation, their influence on remains inadequately understood. Herein, we investigate impact HBM lipid general population cohort. study included mothers (All Babies In Southeast Sweden study) whose children later progressed one or more immune-mediated diseases life: type 1 diabetes (n = 9), celiac disease 24), juvenile idiopathic arthritis inflammatory bowel 7), hypothyroidism 6), matched controls 173). Lipidome was characterized by liquid chromatography combined with high-resolution mass spectrometry. We observed that maternal age, body index, diet, exposure perfluorinated alkyl substances (PFASs) had marked lipidome, larger changes those developed autoimmune diseases. also differences offspring Our suggests is modified complex interaction genetic factors, and, importantly, significantly pronounced autoimmune/inflammatory findings suggest merely assessing PFAS concentration may not capture full extent chemical exposures; thus, comprehensive exposome approach essential for accurately consequently, health outcomes offspring.
Language: Английский
Citations
10
Environmental Pollution, Journal Year: 2025, Volume and Issue: unknown, P. 125737 - 125737
Published: Jan. 1, 2025
Language: Английский
Citations
2
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(33)
Published: June 6, 2024
Non-aqueous electrolytes, generally consisting of metal salts and solvating media, are indispensable elements for building rechargeable batteries. As the major sources ionic charges, intrinsic characters salt anions particular importance in determining fundamental properties bulk electrolyte, as well features resulting electrode-electrolyte interphases/interfaces. To cope with increasing demand better batteries requested by emerging application domains, structural design modifications highly desired. Here, lithium other monovalent (e.g., sodium potassium) multivalent magnesium, calcium, zinc, aluminum) outlined. Fundamental considerations on provided, particularly involving specific requirements imposed different cell chemistries. Historical evolution possible synthetic methodologies representative reviewed. Recent advances tailoring anionic structures scrutinized, due attention is paid to paradigm shift from liquid solid intercalation conversion/alloying-type electrodes, kinds The remaining challenges key research directions development robust also discussed.
Language: Английский
Citations
8
The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 926, P. 171743 - 171743
Published: March 15, 2024
Per- and poly-fluoroalkyl substances (PFAS) pose a threat to organisms ecosystems due their persistent nature. Ecotoxicology endpoints used in regulatory guidelines may not reflect multiple, low-level but stressors. This study examines the biological effects of PFAS on Eastern short-necked turtles Queensland, Australia. In this study, blood samples were collected analysed for PFAS, hormone levels, functional omics endpoints. High levels found at impacted site, with PFOS being dominant constituent. The profiles males females differed, having higher concentrations. Hormone concentrations differed between reference sites male turtles, elevated testosterone corticosterone indicative stress. Further, energy utilisation, nucleotide synthesis, nitrogen metabolism, amino acid synthesis altered both female from PFAS-impacted sites. Both sexes show similar metabolic responses environmental stressors PFAS-contaminated which adversely affect reproductive fitness. Purine caffeine ferroptosis pathway changes can cause gout, cell death, overall health problems. showed that prolonged exposure wild could compromise turtle fitness by disrupting steroids pathways.
Language: Английский
Citations
7
Environmental Pollution, Journal Year: 2025, Volume and Issue: 367, P. 125629 - 125629
Published: Jan. 2, 2025
Language: Английский
Citations
1
Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 489, P. 137613 - 137613
Published: Feb. 13, 2025
Language: Английский
Citations
1
Regulatory Toxicology and Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 105794 - 105794
Published: Feb. 1, 2025
This study employs animal-free Next Generation Risk Assessment (NGRA) principles to evaluate the safety of repeated dermal exposure 2.5% (w/w) HC Yellow No. 13 (HCY13) hair dye. As multiple in silico tools consistently flagged hepatotoxic potential, likely due HCY13's trifluoromethyl group, which is known interfere with hepatic lipid metabolism, liver steatosis was chosen as primary mode action for evaluation. AOP-guided vitro tests were conducted, exposing human stem cell-derived cells varying HCY13 concentrations over 72 hours. The expression 11 metabolism-related marker genes (AHR, PPARA, LXRA, APOB, ACOX1, CPT1A, FASN, SCD1, DGAT2, CD36, and PPARG) triglyceride accumulation, a phenotypic hallmark steatosis, measured. PROAST software used calculate Points Departure (PoDNAM) each biomarker. Using GastroPlus 9.9, physiologically-based pharmacokinetic (PBPK) models estimated internal (Cmax liver) HCY13, ranging from 4 20 pM. All PoDNAM values significantly exceeded predicted Cmax liver, indicating that at unlikely induce under assumed conditions. research demonstrates utility NGRA, integrating AOP-based assays computational protect health support regulatory decision-making without animal testing.
Language: Английский
Citations
1
Environment International, Journal Year: 2024, Volume and Issue: 190, P. 108864 - 108864
Published: July 2, 2024
Perfluorinated alkyl substances (PFAS) are pervasive environmental contaminants that have attracted considerable attention due to their widespread utilization, resilient characteristics, adverse health implications, and regulatory scrutiny. Despite documented toxicity in living organisms, the precise molecular mechanisms governing induced effects remain unclear. This study aims elucidate of toxic action by collecting empirical data sets along oxidative stress metabolic disruption pathways. We investigated impact long-chain PFAS (perfluorooctanoic acid (PFOA)) its short-chain analog (perfluorobutanoic (PFBA)) on human neuronal cells (SH-SY5Y). The functionalities enzymes associated with (catalase glutathione reductase) cellular metabolism (lactate dehydrogenase pyruvate dehydrogenase) were also characterized. Our results reveal a 24-hour exposure PFOA PFBA generated significant levels reactive oxygen species. Correspondingly, there was notable decline catalase reductase activities, demonstrating more pronounced effect. High concentrations reduced activity. Lactate activity only impacted high concentration PFBA, while decreased increased exposure. findings from this contribute knowledge cell interactions potential underlying PFAS-induced toxicity.
Language: Английский
Citations
6