Aberrant salience mediates the interplay between emotional abuse and positive symptoms in schizophrenia DOI Creative Commons
Renato de Filippis, Matteo Aloi, Marco Tullio Liuzza

et al.

Comprehensive Psychiatry, Journal Year: 2024, Volume and Issue: 133, P. 152496 - 152496

Published: May 3, 2024

Childhood trauma and adversities (CTA) aberrant salience (AS) have a pivotal role in schizophrenia development, but their interplay with psychotic symptoms remains vague. We explored the mediation performed by AS between CTA symptomatology schizophrenia. approached 241 adults suffering from spectrum disorders (SSDs), who been unit for at least 12 consecutive months, excluding diagnosis of dementia, recent substance abuse disorder, cross-sectional evaluated through Aberrant Salience Inventory (ASI), Trauma Questionnaire Short-Form (CTQ-SF), Positive Negative Symptom Scale (PANSS). tested path-diagram where mediated relationship psychosis, after verifying each measure one-dimensionality confirmatory factor analysis. The final sample comprised 222 patients (36.9% female), mean age 42.4 (± 13.3) years an average antipsychotic dose 453.6 184.2) mg/day (chlorpromazine equivalents). duration untreated psychosis was 1.8 2.0) while onset 23.9 8.2) years. Significant paths were found emotional to ASI total score (β = 0.39; p < .001) PANSS positive 0.17; .019). Finally, statistically significant indirect association 0.06; .041; CI 95% [0.01, 0.13]). Emotional has AS-mediated effect on symptomatology. evaluation could allow better characterization as well explain presence SSDs experienced CTA.

Language: Английский

Aberrant salience mediates the interplay between emotional abuse and positive symptoms in schizophrenia DOI Creative Commons
Renato de Filippis, Matteo Aloi, Marco Tullio Liuzza

et al.

Comprehensive Psychiatry, Journal Year: 2024, Volume and Issue: 133, P. 152496 - 152496

Published: May 3, 2024

Childhood trauma and adversities (CTA) aberrant salience (AS) have a pivotal role in schizophrenia development, but their interplay with psychotic symptoms remains vague. We explored the mediation performed by AS between CTA symptomatology schizophrenia. approached 241 adults suffering from spectrum disorders (SSDs), who been unit for at least 12 consecutive months, excluding diagnosis of dementia, recent substance abuse disorder, cross-sectional evaluated through Aberrant Salience Inventory (ASI), Trauma Questionnaire Short-Form (CTQ-SF), Positive Negative Symptom Scale (PANSS). tested path-diagram where mediated relationship psychosis, after verifying each measure one-dimensionality confirmatory factor analysis. The final sample comprised 222 patients (36.9% female), mean age 42.4 (± 13.3) years an average antipsychotic dose 453.6 184.2) mg/day (chlorpromazine equivalents). duration untreated psychosis was 1.8 2.0) while onset 23.9 8.2) years. Significant paths were found emotional to ASI total score (β = 0.39; p < .001) PANSS positive 0.17; .019). Finally, statistically significant indirect association 0.06; .041; CI 95% [0.01, 0.13]). Emotional has AS-mediated effect on symptomatology. evaluation could allow better characterization as well explain presence SSDs experienced CTA.

Language: Английский

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