Research,
Journal Year:
2022,
Volume and Issue:
2022
Published: Jan. 1, 2022
Parkinson’s
disease
(PD)
is
the
second
most
common
neurodegenerative
globally,
and
there
currently
no
effective
treatment
for
this
condition.
Excessive
accumulation
of
reactive
oxygen
species
(ROS)
neuroinflammation
are
major
contributors
to
PD
pathogenesis.
Herein,
ultrasmall
nanoscale
coordination
polymers
(NCPs)
coordinated
by
ferric
ions
natural
product
curcumin
(Cur)
were
exploited,
showing
efficient
neuroprotection
scavenging
excessive
radicals
suppressing
neuroinflammation.
In
a
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
(MPTP)-induced
mouse
model,
such
Fe-Cur
NCPs
with
prolonged
blood
circulation
BBB
traversing
capability
could
effectively
alleviate
oxidative
stress,
mitochondrial
dysfunction,
inflammatory
condition
in
midbrain
striatum
reduce
symptoms.
Thus,
study
puts
forth
unique
type
therapeutics-based
that
be
used
safe
potential
clinical
translation.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Jan. 1, 2024
Abstract
Combining
existing
drug
therapy
is
essential
in
developing
new
therapeutic
agents
disease
prevention
and
treatment.
In
preclinical
investigations,
combined
effect
of
certain
known
drugs
has
been
well
established
treating
extensive
human
diseases.
Attributed
to
synergistic
effects
by
targeting
various
pathways
advantages,
such
as
reduced
administration
dose,
decreased
toxicity,
alleviated
resistance,
combinatorial
treatment
now
being
pursued
delivering
combat
major
clinical
illnesses,
cancer,
atherosclerosis,
pulmonary
hypertension,
myocarditis,
rheumatoid
arthritis,
inflammatory
bowel
disease,
metabolic
disorders
neurodegenerative
Combinatorial
involves
combining
or
co-delivering
two
more
for
a
specific
disease.
Nanoparticle
(NP)-mediated
delivery
systems,
i.e.,
liposomal
NPs,
polymeric
NPs
nanocrystals,
are
great
interest
wide
range
due
targeted
delivery,
extended
release,
higher
stability
avoid
rapid
clearance
at
infected
areas.
This
review
summarizes
targets
diseases,
clinically
approved
combinations
the
development
multifunctional
emphasizes
strategies
based
on
severe
Ultimately,
we
discuss
challenging
NP-codelivery
translation
provide
potential
approaches
address
limitations.
offers
comprehensive
overview
recent
cutting-edge
NP-mediated
combination
Journal of Nanobiotechnology,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: July 20, 2023
Abstract
Extracellular
vesicles
(EVs)
are
nano-sized,
natural,
cell-derived
that
contain
the
same
nucleic
acids,
proteins,
and
lipids
as
their
source
cells.
Thus,
they
can
serve
natural
carriers
for
therapeutic
agents
drugs,
have
many
advantages
over
conventional
nanocarriers,
including
low
immunogenicity,
good
biocompatibility,
blood
–
brain
barrier
penetration,
capacity
gene
delivery.
This
review
first
introduces
classification
of
EVs
then
discusses
several
currently
popular
methods
isolating
purifying
EVs,
EVs-mediated
drug
delivery,
functionalization
carriers.
Thereby,
it
provides
new
avenues
development
EVs-based
strategies
in
different
fields
medicine.
Finally,
highlights
some
challenges
future
perspectives
with
regard
to
clinical
application
EVs.
Graphical
Nature Communications,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: Dec. 8, 2023
Nanomedicine-based
anti-neuroinflammation
strategy
has
become
a
promising
dawn
of
Parkinson's
disease
(PD)
treatment.
However,
there
are
significant
gaps
in
our
understanding
the
therapeutic
mechanisms
antioxidant
nanomedicines
concerning
pathways
traversing
blood-brain
barrier
(BBB)
and
subsequent
inflammation
mitigation.
Here,
we
report
nanozyme-integrated
metal-organic
frameworks
with
excellent
activity
chiral-dependent
BBB
transendocytosis
as
anti-neuroinflammatory
agents
for
treatment
PD.
These
chiral
nanozymes
synthesized
by
embedding
ultra-small
platinum
(Ptzymes)
into
L-chiral
D-chiral
imidazolate
zeolite
(Ptzyme@L-ZIF
Ptzyme@D-ZIF).
Compared
to
Ptzyme@L-ZIF,
Ptzyme@D-ZIF
shows
higher
accumulation
brains
male
PD
mouse
models
due
longer
plasma
residence
time
more
traverse
BBB,
including
clathrin-mediated
caveolae-mediated
endocytosis.
factors
contribute
superior
efficacy
reducing
behavioral
disorders
pathological
changes.
Bioinformatics
biochemical
analyses
suggest
that
inhibits
neuroinflammation-induced
apoptosis
ferroptosis
damaged
neurons.
The
research
uncovers
biodistribution,
metabolic
variances,
outcomes
nanozymes-integrated
ZIF
platforms,
providing
possibilities
devising
anti-PD
drugs.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(10)
Published: April 5, 2023
Metabolism
is
the
sum
of
enzyme-dependent
chemical
reactions,
which
produces
energy
in
catabolic
process
and
synthesizes
biomass
anabolic
process,
exhibiting
high
similarity
mammalian
cell,
microbial
plant
cell.
Consequently,
loss
or
gain
metabolic
enzyme
activity
greatly
affects
cellular
metabolism.
Nanozymes,
as
emerging
mimics
with
diverse
functions
adjustable
catalytic
activities,
have
shown
attractive
potential
for
regulation.
Although
basic
tasks
are
highly
similar
cells
from
different
species,
concrete
pathway
varies
intracellular
structure
species.
Here,
metabolism
living
organisms
described
similarities
differences
pathways
among
mammalian,
microbial,
regulation
mechanism
discussed.
The
recent
progress
on
mainly
including
nutrient
uptake
utilization,
production,
accompanied
redox
reactions
by
kinds
oxidoreductases
their
applications
field
disease
therapy,
antimicrobial
sustainable
agriculture
systematically
reviewed.
Furthermore,
prospects
challenges
nanozymes
regulating
cell
also
discussed,
broaden
application
scenarios.
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
33(37)
Published: June 20, 2023
Abstract
Glial
cell‐dominated
inflammatory
microenvironment
and
neuronal
damage
due
to
oxidative
stress
are
major
impediments
the
treatment
of
central
nervous
degenerative
diseases.
Herein,
a
neuroinflammatory
regulatory
nanoreactor
is
developed
by
encapsulating
dihydroquercetin
(Que)
Pt
nanozymes
(Ptzymes)
in
mannitol
modified
poly(lactic‐
co
‐glycolic
acid)
nanoparticles.
The
shows
enhanced
antioxidative
activities
compared
with
either
Que
or
Ptzymes
alone
synergetic
effects
incorporated
active
agents.
In
cellular
animal
models
Parkinson's
disease
(PD),
traverses
blood–brain
barrier
accumulates
neurons
microglia,
thereby
mitigating
neurons,
promoting
polarization
microglia
into
anti‐inflammatory
M2‐phenotype
control
PD
progression.
This
work
demonstrates
gains
combining
anti‐inflammation
small
molecule
compound
antioxidant
nanozyme
effectively
prevent
suppress
microenvironment,
which
holds
great
potential
for
managing
advances
PD.
Neural Regeneration Research,
Journal Year:
2023,
Volume and Issue:
19(4), P. 833 - 845
Published: Aug. 14, 2023
A
growing
body
of
evidence
suggests
that
the
gut
microbiota
contributes
to
development
neurodegenerative
diseases
via
microbiota-gut-brain
axis.
As
a
contributing
factor,
dysbiosis
always
occurs
in
pathological
changes
diseases,
such
as
Alzheimer's
disease,
Parkinson's
and
amyotrophic
lateral
sclerosis.
High-throughput
sequencing
technology
has
helped
reveal
bidirectional
communication
between
central
nervous
system
enteric
is
facilitated
by
microbiota's
diverse
microorganisms,
for
both
neuroimmune
neuroendocrine
systems.
Here,
we
summarize
bioinformatics
analysis
wet-biology
validation
metagenomics
with
an
emphasis
on
multi-omics
studies
virome.
The
pathogen-associated
signaling
biomarkers
identifying
brain
disorders
potential
therapeutic
targets
are
also
elucidated.
Finally,
discuss
role
diet,
prebiotics,
probiotics,
postbiotics
exercise
interventions
remodeling
microbiome
reducing
symptoms
diseases.
Molecular Aspects of Medicine,
Journal Year:
2024,
Volume and Issue:
99, P. 101302 - 101302
Published: Aug. 1, 2024
Modern
methods
of
molecular
diagnostics
and
therapy
have
revolutionized
the
field
medicine
in
recent
years
by
providing
more
precise
effective
tools
for
detecting
treating
diseases.
This
progress
includes
a
growing
exploration
body's
secreted
vesicles,
known
as
extracellular
vesicles
(EVs),
both
diagnostic
therapeutic
purposes.
EVs
are
heterogeneous
population
lipid
bilayer
almost
every
cell
type
studied
so
far.
They
detected
body
fluids
conditioned
culture
media
from
living
cells.
play
crucial
role
communication
between
cells
organs,
locally
over
long
distances.
recognized
their
ability
to
transport
endogenous
RNA
proteins
cells,
including
messenger
(mRNA),
microRNA
(miRNA),
misfolded
neurodegenerative
proteins,
several
other
biomolecules.
review
explores
dual
utilization
EVs,
serving
not
only
purposes
but
also
platform
delivering
molecules
tissues.
Through
an
composition,
biogenesis,
selective
cargo
packaging,
we
elucidate
intricate
mechanisms
behind
via
highlighting
potential
use
applications.
Finally,
it
addresses
challenges
outlines
prospective
directions
clinical
EVs.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(16)
Published: Feb. 28, 2024
Abstract
Traditional
Chinese
Medicine
(TCM)
is
widely
used
in
clinical
practice
to
treat
diseases
related
central
nervous
system
(CNS)
damage.
However,
the
blood‐brain
barrier
(BBB)
constitutes
a
significant
impediment
effective
delivery
of
TCM,
thus
substantially
diminishing
its
efficacy.
Advances
nanotechnology
and
applications
TCM
(also
known
as
nano‐TCM)
can
deliver
active
ingredients
or
components
across
BBB
targeted
brain
region.
This
review
provides
an
overview
physiological
pathological
mechanisms
systematically
classifies
common
CNS
types
nanocarriers
that
effectively
brain.
Additionally,
drug
strategies
for
nano‐TCMs
utilize
vivo
properties
vitro
devices
bypass
cross
are
discussed.
further
focuses
on
application
treatment
various
diseases.
Finally,
this
article
anticipates
design
strategy
with
higher
efficiency
probes
their
potential
treating
wider
range
