Ageing Research Reviews, Год журнала: 2023, Номер 87, С. 101921 - 101921
Опубликована: Март 31, 2023
Язык: Английский
Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)
Опубликована: Янв. 1, 2024
Abstract Combining existing drug therapy is essential in developing new therapeutic agents disease prevention and treatment. In preclinical investigations, combined effect of certain known drugs has been well established treating extensive human diseases. Attributed to synergistic effects by targeting various pathways advantages, such as reduced administration dose, decreased toxicity, alleviated resistance, combinatorial treatment now being pursued delivering combat major clinical illnesses, cancer, atherosclerosis, pulmonary hypertension, myocarditis, rheumatoid arthritis, inflammatory bowel disease, metabolic disorders neurodegenerative Combinatorial involves combining or co-delivering two more for a specific disease. Nanoparticle (NP)-mediated delivery systems, i.e., liposomal NPs, polymeric NPs nanocrystals, are great interest wide range due targeted delivery, extended release, higher stability avoid rapid clearance at infected areas. This review summarizes targets diseases, clinically approved combinations the development multifunctional emphasizes strategies based on severe Ultimately, we discuss challenging NP-codelivery translation provide potential approaches address limitations. offers comprehensive overview recent cutting-edge NP-mediated combination
Язык: Английский
Процитировано
143
Journal of Nanobiotechnology, Год журнала: 2023, Номер 21(1)
Опубликована: Июль 20, 2023
Abstract Extracellular vesicles (EVs) are nano-sized, natural, cell-derived that contain the same nucleic acids, proteins, and lipids as their source cells. Thus, they can serve natural carriers for therapeutic agents drugs, have many advantages over conventional nanocarriers, including low immunogenicity, good biocompatibility, blood – brain barrier penetration, capacity gene delivery. This review first introduces classification of EVs then discusses several currently popular methods isolating purifying EVs, EVs-mediated drug delivery, functionalization carriers. Thereby, it provides new avenues development EVs-based strategies in different fields medicine. Finally, highlights some challenges future perspectives with regard to clinical application EVs. Graphical
Язык: Английский
Процитировано
115
Nature Communications, Год журнала: 2023, Номер 14(1)
Опубликована: Дек. 8, 2023
Nanomedicine-based anti-neuroinflammation strategy has become a promising dawn of Parkinson's disease (PD) treatment. However, there are significant gaps in our understanding the therapeutic mechanisms antioxidant nanomedicines concerning pathways traversing blood-brain barrier (BBB) and subsequent inflammation mitigation. Here, we report nanozyme-integrated metal-organic frameworks with excellent activity chiral-dependent BBB transendocytosis as anti-neuroinflammatory agents for treatment PD. These chiral nanozymes synthesized by embedding ultra-small platinum (Ptzymes) into L-chiral D-chiral imidazolate zeolite (Ptzyme@L-ZIF Ptzyme@D-ZIF). Compared to Ptzyme@L-ZIF, Ptzyme@D-ZIF shows higher accumulation brains male PD mouse models due longer plasma residence time more traverse BBB, including clathrin-mediated caveolae-mediated endocytosis. factors contribute superior efficacy reducing behavioral disorders pathological changes. Bioinformatics biochemical analyses suggest that inhibits neuroinflammation-induced apoptosis ferroptosis damaged neurons. The research uncovers biodistribution, metabolic variances, outcomes nanozymes-integrated ZIF platforms, providing possibilities devising anti-PD drugs.
Язык: Английский
Процитировано
71
Advanced Materials, Год журнала: 2023, Номер 36(10)
Опубликована: Апрель 5, 2023
Metabolism is the sum of enzyme-dependent chemical reactions, which produces energy in catabolic process and synthesizes biomass anabolic process, exhibiting high similarity mammalian cell, microbial plant cell. Consequently, loss or gain metabolic enzyme activity greatly affects cellular metabolism. Nanozymes, as emerging mimics with diverse functions adjustable catalytic activities, have shown attractive potential for regulation. Although basic tasks are highly similar cells from different species, concrete pathway varies intracellular structure species. Here, metabolism living organisms described similarities differences pathways among mammalian, microbial, regulation mechanism discussed. The recent progress on mainly including nutrient uptake utilization, production, accompanied redox reactions by kinds oxidoreductases their applications field disease therapy, antimicrobial sustainable agriculture systematically reviewed. Furthermore, prospects challenges nanozymes regulating cell also discussed, broaden application scenarios.
Язык: Английский
Процитировано
50
Advanced Functional Materials, Год журнала: 2023, Номер 33(37)
Опубликована: Июнь 20, 2023
Abstract Glial cell‐dominated inflammatory microenvironment and neuronal damage due to oxidative stress are major impediments the treatment of central nervous degenerative diseases. Herein, a neuroinflammatory regulatory nanoreactor is developed by encapsulating dihydroquercetin (Que) Pt nanozymes (Ptzymes) in mannitol modified poly(lactic‐ co ‐glycolic acid) nanoparticles. The shows enhanced antioxidative activities compared with either Que or Ptzymes alone synergetic effects incorporated active agents. In cellular animal models Parkinson's disease (PD), traverses blood–brain barrier accumulates neurons microglia, thereby mitigating neurons, promoting polarization microglia into anti‐inflammatory M2‐phenotype control PD progression. This work demonstrates gains combining anti‐inflammation small molecule compound antioxidant nanozyme effectively prevent suppress microenvironment, which holds great potential for managing advances PD.
Язык: Английский
Процитировано
31
Neural Regeneration Research, Год журнала: 2023, Номер 19(4), С. 833 - 845
Опубликована: Авг. 14, 2023
A growing body of evidence suggests that the gut microbiota contributes to development neurodegenerative diseases via microbiota-gut-brain axis. As a contributing factor, dysbiosis always occurs in pathological changes diseases, such as Alzheimer's disease, Parkinson's and amyotrophic lateral sclerosis. High-throughput sequencing technology has helped reveal bidirectional communication between central nervous system enteric is facilitated by microbiota's diverse microorganisms, for both neuroimmune neuroendocrine systems. Here, we summarize bioinformatics analysis wet-biology validation metagenomics with an emphasis on multi-omics studies virome. The pathogen-associated signaling biomarkers identifying brain disorders potential therapeutic targets are also elucidated. Finally, discuss role diet, prebiotics, probiotics, postbiotics exercise interventions remodeling microbiome reducing symptoms diseases.
Язык: Английский
Процитировано
31
Chemical Engineering Journal, Год журнала: 2023, Номер 461, С. 141606 - 141606
Опубликована: Янв. 30, 2023
Язык: Английский
Процитировано
28
3 Biotech, Год журнала: 2023, Номер 13(5)
Опубликована: Апрель 27, 2023
Язык: Английский
Процитировано
28
Molecular Aspects of Medicine, Год журнала: 2024, Номер 99, С. 101302 - 101302
Опубликована: Авг. 1, 2024
Modern methods of molecular diagnostics and therapy have revolutionized the field medicine in recent years by providing more precise effective tools for detecting treating diseases. This progress includes a growing exploration body's secreted vesicles, known as extracellular vesicles (EVs), both diagnostic therapeutic purposes. EVs are heterogeneous population lipid bilayer almost every cell type studied so far. They detected body fluids conditioned culture media from living cells. play crucial role communication between cells organs, locally over long distances. recognized their ability to transport endogenous RNA proteins cells, including messenger (mRNA), microRNA (miRNA), misfolded neurodegenerative proteins, several other biomolecules. review explores dual utilization EVs, serving not only purposes but also platform delivering molecules tissues. Through an composition, biogenesis, selective cargo packaging, we elucidate intricate mechanisms behind via highlighting potential use applications. Finally, it addresses challenges outlines prospective directions clinical EVs.
Язык: Английский
Процитировано
14
Advanced Science, Год журнала: 2024, Номер 11(16)
Опубликована: Фев. 28, 2024
Abstract Traditional Chinese Medicine (TCM) is widely used in clinical practice to treat diseases related central nervous system (CNS) damage. However, the blood‐brain barrier (BBB) constitutes a significant impediment effective delivery of TCM, thus substantially diminishing its efficacy. Advances nanotechnology and applications TCM (also known as nano‐TCM) can deliver active ingredients or components across BBB targeted brain region. This review provides an overview physiological pathological mechanisms systematically classifies common CNS types nanocarriers that effectively brain. Additionally, drug strategies for nano‐TCMs utilize vivo properties vitro devices bypass cross are discussed. further focuses on application treatment various diseases. Finally, this article anticipates design strategy with higher efficiency probes their potential treating wider range
Язык: Английский
Процитировано
13