Recent Advances in Electrospinning Techniques for Precise Medicine

Cyborg and Bionic Systems, Journal Year: 2024, Volume and Issue: 5

Published: Jan. 1, 2024

In the realm of precise medicine, advancement manufacturing technologies is vital for enhancing capabilities medical devices such as nano/microrobots, wearable/implantable biosensors, and organ-on-chip systems, which serve to accurately acquire analyze patients’ physiopathological information perform patient-specific therapy. Electrospinning holds great promise in engineering materials components advanced devices, due demonstrated ability advance development nanomaterial science. Nevertheless, challenges limited composition variety, uncontrollable fiber orientation, difficulties incorporating fragile molecules cells, low production effectiveness hindered its further application. To overcome these challenges, electrospinning techniques have been explored manufacture functional composites, orchestrated structures, living constructs, scale-up fabrication. This review delves into recent advances underscores their potential revolutionizing field upon introducing fundamental conventional techniques, well discussing current future perspectives.

Language: Английский

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3D printed grafts with gradient structures for organized vascular regeneration

International Journal of Extreme Manufacturing, Journal Year: 2024, Volume and Issue: 6(3), P. 035503 - 035503

Published: March 2, 2024

Abstract Synthetic vascular grafts suitable for small-diameter arteries (<6 mm) are in great need. However, there still no commercially available (SDVGs) clinical practice due to thrombosis and stenosis after vivo implantation. When designing SDVGs, many studies emphasized reendothelization but ignored the importance of reconstruction smooth muscle layer (SML). To facilitate rapid SML regeneration, a high-resolution 3D printing method was used create novel bilayer SDVG with structures mechanical properties mimicking natural arteries. Bioinspired by collagen alignment SML, inner had larger pore sizes high porosity accelerate infiltration cells their circumferential alignment, which could compliance restoration spontaneous endothelialization. The outer designed induce fibroblast recruitment low minor size provide sufficient strength. One month implantation, regenerated 3D-printed exhibited better pulsatility than electrospun grafts, (8.9%) approaching that (11.36%) significantly higher ones (1.9%). demonstrated three-layer structure more closely resembling while showed incomplete endothelium immature SML. Our study shows during graft regeneration provides an effective strategy reconstruct blood vessels through rapidly.

Language: Английский

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Microgels for Cell Delivery in Tissue Engineering and Regenerative Medicine

Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 16(1)

Published: June 17, 2024

Abstract Microgels prepared from natural or synthetic hydrogel materials have aroused extensive attention as multifunctional cells drug carriers, that are promising for tissue engineering and regenerative medicine. can also be aggregated into microporous scaffolds, promoting cell infiltration proliferation repair. This review gives an overview of recent developments in the fabrication techniques applications microgels. A series conventional novel strategies including emulsification, microfluidic, lithography, electrospray, centrifugation, gas-shearing, three-dimensional bioprinting, etc. discussed depth. The characteristics microgels microgel-based scaffolds culture delivery elaborated with emphasis on advantages these carriers therapy. Additionally, we expound ongoing foreseeable current limitations their aggregate field biomedical engineering. Through stimulating innovative ideas, present paves new avenues expanding application techniques.

Language: Английский

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A Spatiotemporal Controllable Biomimetic Skin for Accelerating Wound Repair

Small, Journal Year: 2024, Volume and Issue: 20(23)

Published: Feb. 22, 2024

Abstract Skin injury repair is a dynamic process involving series of interactions over time and space. Linking human physiological processes with materials’ changes poses significant challenge. To match the wound healing process, spatiotemporal controllable biomimetic skin developed, which comprises three‐dimensional (3D) printed membrane as epidermis, cell‐containing hydrogel dermis, cytokine‐laden hypodermis. In initial stage wound, frame aids closure through pre‐tension, while cells proliferate within hydrogel. Next, disintegrates time, released from migrate along residual membrane. Throughout continuous cytokines release hypodermis ensures comprehensive nourishment. The findings reveal that in rat full‐thickness defect model, demonstrated rate eight times higher than blank group, double collagen content, particularly early process. Consequently, it reasonable to infer this holds promising potential accelerate repair. This mechanobiological effects regulation emerges option for tissue regeneration engineering.

Language: Английский

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Performance optimization of hydrogels from gelatin towards the sensing and monitoring applications

European Polymer Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113715 - 113715

Published: Jan. 1, 2025

Language: Английский

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Bio‐Inspired Highly Stretchable and Ultrafast Autonomous Self‐Healing Supramolecular Hydrogel for Multifunctional Durable Self‐Powered Wearable Devices

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Abstract As skin bioelectronics advances, hydrogel wearable devices have broadened perspectives in environment sensing and health monitoring. However, their application is severely hampered by poor mechanical self‐healing properties, environmental sensitivity, limited sensory functions. Herein, inspired the hierarchical structure unique cross‐linking mechanism of hagfish slime, a self‐powered supramolecular hereby reported, featuring high stretchability (>2800% strain), ultrafast autonomous capabilities (electrical healing time: 0.3 s), self‐adhesiveness (adhesion strength: 6.92 kPa), injectability, ease shaping, antimicrobial biocompatibility. It observed that embedding with highly hygroscopic salt LiCl hydrogel, not only showed excellent electrical conductivity but also presented favorable anti‐freezing water retention properties extremely cold environments natural settings. Given these attributes, served as multifunctional durable device sensitivity (gauge factor: 3.68), fast response time (160 ms), low detection limit, frequency sensitivity. Moreover, applicability this further demonstrated long‐term sensing, remote medical communication, underwater communication. Overall, findings pave way for sustainable development hydrogel‐based are self‐powered, durable, offer performance, adaptability, multi‐sensory capabilities.

Language: Английский

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Strong Tough Hydrogel with Regional Programmable Mechanical Properties via Universal Physical Directional Anneal‐Casting Strategy for Bioengineering

Small Structures, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 2, 2025

Engineering tissue‐like hydrogels with tailored mechanical properties and matching water contents is essential for biomimetic organ platforms in both ex vivo biomedical applications. Achieving this goal particularly challenging due to the need a green, straightforward, universally applicable approach mimic various tissues specific hydrogels. Herein, universal physical one‐step directional anneal‐casting strategy anisotropic evaporation presented produce hierarchical poly(vinyl alcohol) hydrogel tunable Young's modulus (≈0.13–77.2 MPa) wide range. As typical example, ultimate stress, toughness, fracture energy, fatigue threshold of strong tough can be up 31.8 MPa, 45.7 MJ m −3 , 568.6 kJ −2 407.8 J at ≈208% strain controllable content (≈20–80%) without compromising their toughness. Integral our capability localized control within same unit, allowing distinct functional characteristics different regions hydrogel. Furthermore, versatility extends other systems, such as polyacrylamide alginate, broadening its applicability fields bioelectronics engineering, including development physiological signal acquisition devices artificial implantable electronic ligaments.

Language: Английский

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Mechanical Metamaterials for Bioengineering: In Vitro, Wearable, and Implantable Applications

Advanced Engineering Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

Mechanical metamaterials represent a promising class of materials characterized by unconventional mechanical properties derived from their engineered architectures. In the realm bioengineering, these offer unique opportunities for applications spanning in vitro models, wearable devices, and implantable biomedical technologies. This review discusses recent advancements bioengineering contexts. metamaterials, tailored to mimic specific biological tissues, enhance fidelity relevance models disease modeling therapy testing. Integration into devices enables creation comfortable adaptive interfaces with human body. Utilization promotes tissue regeneration, supports biomechanical functions, minimizes host immune responses. Key design strategies material selection criteria critical optimizing performance biocompatibility are elucidated. Representative case studies demonstrating benchtop phantoms scaffolds (in platforms); footwear, architectured fabrics, epidermal sensors (wearables); cardiovascular, gastrointestinal, orthopedic multifunctional patches highlighted. Finally, challenges future directions field discussed, emphasizing potential transform research enabling novel functionalities improving outcomes across diverse use cases.

Language: Английский

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Breathable Ultrathin Film Sensors Based on Nanomesh Reinforced Anti‐Dehydrating Organohydrogels for Motion Monitoring

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 6, 2024

Abstract Flexible hydrogel film sensors have great advantages as human–machine interfaces for conformal contact with bio‐tissues, but suffer from weakness and dehydration, compromising flexibility performance. Here, a breathable, highly stretchable, anti‐dehydrating ultrathin organohydrogel skin‐attachable strain sensor long‐term motion monitoring is developed. An electrospun TPU (eTPU) nanomesh hidden strength used skeleton to host in situ free radical polymerization of 2‐acrylamido‐2‐methyl propane sulfonic acid (AMPS) acrylamide (AAm) form an interpenetrating double network glycerol water solvent. Extensive hydrogen bonding between eTPU P(AMPS‐ co ‐AAm) yields (≈200 µm) synergetic deformation energy dissipation upon stretching, leading record‐high stretchability up 920%, fracture toughness 20.14 MJ m −3 , 10 000 J −2 robustness over 4000 notched stretching cylcles 50% strain. The binary glycerol/water solvent imparts excellent anti‐dehydration at room temperature d, stable sensory performance −20 60 °C. With high vapor transmission rate 1.3 kg d −1 the ensures comfortable skin continuous knee flexion throughout day signals. These are promising wearable applications.

Language: Английский

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3D Printing of Tough Hydrogel Scaffolds with Functional Surface Structures for Tissue Regeneration

Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 17(1)

Published: Sept. 29, 2024

Abstract Hydrogel scaffolds have numerous potential applications in the tissue engineering field. However, tough hydrogel implanted vivo are seldom reported because it is difficult to balance biocompatibility and high mechanical properties. Inspired by Chinese ramen, we propose a universal fabricating method (printing-P, training-T, cross-linking-C, PTC & PCT) for fill this gap. First, 3D printing fabricates scaffold with desired structures (P). Then, could extraordinarily properties functional surface structure cycle training salting-out assistance (T). Finally, results fixed photo-cross-linking processing (C). The gelatin exhibit excellent tensile strength of 6.66 MPa (622-fold untreated) biocompatibility. Furthermore, possesses from nanometer micron millimeter, which can efficiently induce directional cell growth. Interestingly, strategy produce bionic human 10 kPa-10 changing type salt, many hydrogels, such as silk, be improved or PCT strategies. Animal experiments show that effectively promote new generation muscle fibers, blood vessels, nerves within 4 weeks, prompting rapid regeneration large-volume loss injuries.

Language: Английский

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