Published: Jan. 1, 2024
Language: Английский
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 518, P. 216089 - 216089
Published: July 16, 2024
Language: Английский
Citations
15
Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 16(1)
Published: June 17, 2024
Abstract Microgels prepared from natural or synthetic hydrogel materials have aroused extensive attention as multifunctional cells drug carriers, that are promising for tissue engineering and regenerative medicine. can also be aggregated into microporous scaffolds, promoting cell infiltration proliferation repair. This review gives an overview of recent developments in the fabrication techniques applications microgels. A series conventional novel strategies including emulsification, microfluidic, lithography, electrospray, centrifugation, gas-shearing, three-dimensional bioprinting, etc. discussed depth. The characteristics microgels microgel-based scaffolds culture delivery elaborated with emphasis on advantages these carriers therapy. Additionally, we expound ongoing foreseeable current limitations their aggregate field biomedical engineering. Through stimulating innovative ideas, present paves new avenues expanding application techniques.
Language: Английский
Citations
12
Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 16(1)
Published: May 2, 2024
As a new form of regulated cell death, ferroptosis has unraveled the unsolicited theory intrinsic apoptosis resistance by cancer cells. The molecular mechanism depends on induction oxidative stress through excessive reactive oxygen species accumulation and glutathione depletion to damage structural integrity Due their high loading tunability, nanocarriers can escort delivery ferro-therapeutics desired site enhanced permeation or retention effect active targeting. This review shed light necessity iron in growth fascinating features regulating cycle metastasis. Additionally, we discussed ferroptosis-mediated therapy using nanoplatforms chemical basis overcoming barriers therapy.
Language: Английский
Citations
11
Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(17), P. 4301 - 4334
Published: Jan. 1, 2024
Microrobots, which can perform tasks in difficult-to-reach parts of the human body under their own or external power supply, are potential tools for biomedical applications, such as drug delivery, microsurgery, imaging and monitoring, tissue engineering, sensors actuators. Compared with traditional fabrication methods microrobots, recent improvements 3D printers enable them to print high-precision breaking through limitations micromanufacturing technologies that require high skills operators greatly shortening design-to-production cycle. Here, this review first introduces typical printing used microrobot manufacturing. Then, structures microrobots different functions application scenarios discussed. Next, we summarize materials (body materials, propulsion intelligent materials) manufacturing complete construction realize applications (
Language: Английский
Citations
7
International Journal of Extreme Manufacturing, Journal Year: 2024, Volume and Issue: 6(6), P. 062006 - 062006
Published: Aug. 21, 2024
Abstract Micro/nanorobots (MNRs) capable of performing tasks at the micro- and nanoscale hold great promise for applications in cutting-edge fields such as biomedical engineering, environmental microfabrication. To cope with intricate dynamic environments encountered practical applications, development high performance MNRs is crucial. They have evolved from single-material, single-function, simple structure to multi-material, multi-function, complex structure. However, design manufacturing multi-material three-dimensional structures pose significant challenges that cannot be addressed by conventional serial strategies single-process methods. The material-interface-structure-function/ coupled methods additive/formative/subtractive composite offer opportunity manufacture multi-materials under multi-factor coupling, thus paving way MNRs. In this paper, we take three core capabilities MNRs—mobility, controllability, load capability—as focal point, emphasizing oriented towards their function/performance functional structures. limitations current investigation are also discussed, our envisioned future directions shared. We hope review will provide a framework template MNRs, serving roadmap researchers interested area.
Language: Английский
Citations
5
Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106626 - 106626
Published: April 1, 2025
Language: Английский
Citations
0
Biosensors, Journal Year: 2025, Volume and Issue: 15(2), P. 115 - 115
Published: Feb. 16, 2025
Surface-enhanced Raman spectroscopy (SERS) has emerged as a powerful noninvasive analytical technique with widespread applications in biochemical analysis and biomedical diagnostics. The need for highly sensitive, reproducible, efficient detection of biomolecules complex biological environments driven significant advancements SERS-based biosensing platforms. In this context, micro/nanomachines (MNMs) have garnered attention versatile SERS-active substrates due to their unique structural motional characteristics at the micro- nanoscale. This review explores advantages integrating MNMs SERS biosensing, discussing recent technological advances, various propulsion strategies, potential range applications.
Language: Английский
Citations
0
Macromolecular Rapid Communications, Journal Year: 2025, Volume and Issue: unknown
Published: March 5, 2025
Chemically powered colloidal motors are self-propelled tiny machines capable of converting chemical energy into mechanical work or kinetic energy. A wide variety organic inorganic substrates selectively utilized as consumable fuels that would allow the creation a gradient concentration via catalytic reactions for driving controllable transport in various complex liquid environments, unlocking potential chemically large range applications. Recently, combinations synthetic chemistry and nanotechnology have been exploited to design construct degradable polymer-fueled artificial whose propulsion relies on rapid degradation stimuli-responsive polymers with labile units nanostructured smart systems under activation physical stimuli. This review highlights most recent advances by polymer fuels. It explores general fabrication approaches asymmetric morphologies powering mechanisms toward motion media biological microenvironments. The distinct application performance developed so far is reviewed. future perspective development also proposed.
Language: Английский
Citations
0
Advanced Intelligent Systems, Journal Year: 2025, Volume and Issue: unknown
Published: April 6, 2025
Micro/nanorobots (MNRs) are untethered, small‐scale devices designed to perform complex tasks in challenging and inaccessible environments, with promising biomedicine environmental remediation applications. Recent advancements multi‐module MNRs, which incorporate functional components such as actuators, propellers, imaging modalities, manipulators, have significantly expanded their capabilities while addressing the limitations of single‐module designs. This article reviews recent progress these core modules, emphasizing application biomedicine, including targeted drug delivery, tissue repair, diagnosis, well remediation, pollutant removal microorganism treatment. It highlights practical strategies address real‐world challenges domains, a focus on design enhancing functionality. Despite substantial advancements, key persist, scalability, real‐time imaging, intelligent control. Future research directions include development modules equipped memory, data processing, communication functions, enabling autonomous decision‐making closed‐loop These developments hold potential foster innovation medicine, sustainability, other critical fields.
Language: Английский
Citations
0
Bioconjugate Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 27, 2024
Self-propelled micro/nanomotors (MNMs) represent a groundbreaking advancement in precision drug delivery, offering potential solutions to persistent challenges such as systemic toxicity, limited bioavailability, and nonspecific distribution. By transforming various energy sources into mechanical motion, MNMs are able autonomously navigate through complex physiological environments, facilitating targeted delivery of therapeutic agents previously inaccessible regions. However, achieve efficient vivo biomedical must demonstrate their ability overcome crucial barriers encompassing mucosal surfaces, blood flow dynamics, vascular endothelium, cellular membrane. This review provides comprehensive overview the latest strategies developed address these obstacles while also analyzing broader opportunities associated with clinical translation. Our objective is establish solid foundation for future research medical by focusing on enhancing efficiency advancing medicine, ultimately paving way practical theragnostic applications wider adoption.
Language: Английский
Citations
1