Advances in Research of Hydrogel Microneedle-Based Delivery Systems for Disease Treatment DOI Creative Commons
Juan Cao, Bo Wu, Ping Yuan

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(12), P. 1571 - 1571

Published: Dec. 9, 2024

Microneedles (MNs), composed of multiple micron-scale needle-like structures attached to a base, offer minimally invasive approach for transdermal drug delivery by penetrating the stratum corneum and delivering therapeutic agents directly epidermis or dermis. Hydrogel microneedles (HMNs) stand out among various MN types due their excellent biocompatibility, high drug-loading capacity, tunable drug-release properties. This review systematically examines matrix materials fabrication methods HMN systems, highlighting advancements in natural synthetic polymers, explores applications treating conditions such as wound healing, hair loss, cardiovascular diseases, cancer. Furthermore, potential HMNs disease diagnostics is discussed. The identifies key challenges, including limited mechanical strength, efficiency, lack standardization, while proposing strategies overcome these issues. With integration intelligent design enhanced control over dosage safety, are poised revolutionize expand personalized medicine.

Language: Английский

Recent progress in the 3D printing of microneedle patches for biomedical applications DOI
Huan Liu,

Aminov Nail,

Decheng Meng

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 124995 - 124995

Published: Nov. 1, 2024

Language: Английский

Citations

4
Polysaccharides as submucosal injection materials (SIMs) in endoscopic resection: A comprehensive review DOI

Yaochen Yang,

Tingting Wang,

Miaomiao Xiao

et al.

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 355, P. 123360 - 123360

Published: Feb. 5, 2025

Language: Английский

Citations

0
Ozone exposure and increased risk of age-related macular degeneration: Evidence from nationwide cohort and toxicological studies DOI Creative Commons
Guanran Zhang, Yanlin Qu, Xiaoling Wan

et al.

The Innovation, Journal Year: 2025, Volume and Issue: unknown, P. 100808 - 100808

Published: Feb. 1, 2025

Language: Английский

Citations

0
A gelatin microneedles featuring antibacterial and reactive oxygen species scavenging properties for treating Vibrio vulnificus-infected wounds DOI

Yuling Shu,

Yi Qi, Yan Zou

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142640 - 142640

Published: March 1, 2025

Language: Английский

Citations

0
Drug-free hyaluronic acid-microneedle with unexpected inhibition activity on benzalkonium chloride-induced corneal inflammation and stromal scarring DOI Creative Commons
Baoshan Huang, Rui Zeng, Xiao Liu

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 32, P. 101722 - 101722

Published: April 1, 2025

Topical instilling of commercial artificial tears (cAT, containing 0.1 % hyaluronic acid) is widely employed to alleviate clinical manifestations mild dry eye disease (DED) by preventing the pathological change corneal epithelium. However, it showed limited therapy effectiveness on heavy DED which has further involved stroma, due its low stroma-available for acid (HA) resulting from barrier The present study developed a new microneedle-dosage form cAT (cAT-MN). This cAT-MN can overstride epithelium and act as long-lasting protective agent. Compared dosing (4 times/day), with one treatment exerted significantly higher therapeutic effects curbing benzalkonium chloride (BAC)-induced stroma scaring well alleviating symptoms in first 5-day BAC exposure; whereas, 10-day exposure. To expand effects, MNs various amounts HA were prepared. Thereinto, HA(6 %)-MN recovered damage healthy levels, could be attributed adding both increasing HA-delivery enhancing HA-permeation. explores drug-free cure disorders expanded indication, promising wide use ophthalmology.

Language: Английский

Citations

0
Polymeric Microneedles for Biomedical Applications: Innovations in Transdermal Drug Delivery and Biosensing Technologies DOI
Wendel A. Alves, Jose E. U. Rojas,

Ana C. H. Castro-Kochi

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Language: Английский

Citations

0
The effect and mechanism of enhanced photocatalytic fungicidal activity on nitrogen doped carbon dots-modified titanium dioxide DOI

Menghui Chi,

Lingwen Gu, Ke Liu

et al.

Carbon, Journal Year: 2025, Volume and Issue: unknown, P. 120314 - 120314

Published: April 1, 2025

Language: Английский

Citations

0
Advances in Research of Hydrogel Microneedle-Based Delivery Systems for Disease Treatment DOI Creative Commons
Juan Cao, Bo Wu, Ping Yuan

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(12), P. 1571 - 1571

Published: Dec. 9, 2024

Microneedles (MNs), composed of multiple micron-scale needle-like structures attached to a base, offer minimally invasive approach for transdermal drug delivery by penetrating the stratum corneum and delivering therapeutic agents directly epidermis or dermis. Hydrogel microneedles (HMNs) stand out among various MN types due their excellent biocompatibility, high drug-loading capacity, tunable drug-release properties. This review systematically examines matrix materials fabrication methods HMN systems, highlighting advancements in natural synthetic polymers, explores applications treating conditions such as wound healing, hair loss, cardiovascular diseases, cancer. Furthermore, potential HMNs disease diagnostics is discussed. The identifies key challenges, including limited mechanical strength, efficiency, lack standardization, while proposing strategies overcome these issues. With integration intelligent design enhanced control over dosage safety, are poised revolutionize expand personalized medicine.

Language: Английский

Citations

0