Progress in Additive Manufacturing,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 10, 2024
Abstract
Two
vat
polymerization
techniques
were
evaluated
to
print
innovative
hydrogel
scaffolds
for
tissue
engineering,
from
aqueous
photo-crosslinkable
formulations
based
on
methacrylated
carboxymethylcellulose
(mCMC).
A
first
formulation
containing
2
wt%
mCMC
with
a
methacrylation
degree
(DM)
of
34%
and
lithium
phenyl-2,4,6-trimethylbenzoylphosphinate
(LAP)
as
photoinitiator
was
specifically
developed
digital
light
processing
(DLP).
Considering
their
viscoelastic
properties
measured
by
shear
rheology,
the
DLP-printed
hydrogels
proposed
soft-tissue
repair.
Interestingly,
swelling
ratio
shape
printed
found
be
preserved
when
immersed
in
physiological
environment.
While
demonstrated
impressive
X-
Y-resolutions
(85
µm),
they
limited
producing
hollow
objects
Z-direction.
To
address
this
limitation,
3D
printing
complex
through
two-photon
(TPP)
investigated
time,
using
second
composed
4
(DM
=
50%).
cavities
30
µm
successfully
resolution
10
µm,
paving
way
design
controlled
precise
structures,
engineering.
Graphical
abstract
Progress in Additive Manufacturing,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 10, 2024
Abstract
Two
vat
polymerization
techniques
were
evaluated
to
print
innovative
hydrogel
scaffolds
for
tissue
engineering,
from
aqueous
photo-crosslinkable
formulations
based
on
methacrylated
carboxymethylcellulose
(mCMC).
A
first
formulation
containing
2
wt%
mCMC
with
a
methacrylation
degree
(DM)
of
34%
and
lithium
phenyl-2,4,6-trimethylbenzoylphosphinate
(LAP)
as
photoinitiator
was
specifically
developed
digital
light
processing
(DLP).
Considering
their
viscoelastic
properties
measured
by
shear
rheology,
the
DLP-printed
hydrogels
proposed
soft-tissue
repair.
Interestingly,
swelling
ratio
shape
printed
found
be
preserved
when
immersed
in
physiological
environment.
While
demonstrated
impressive
X-
Y-resolutions
(85
µm),
they
limited
producing
hollow
objects
Z-direction.
To
address
this
limitation,
3D
printing
complex
through
two-photon
(TPP)
investigated
time,
using
second
composed
4
(DM
=
50%).
cavities
30
µm
successfully
resolution
10
µm,
paving
way
design
controlled
precise
structures,
engineering.
Graphical
abstract