Nano‐Micro Granular Ink with Modulatable Structure and Function Modules for Wound Dressing Preparation via 3D Printing DOI
Tao Wang,

Dawei Niu,

Haowei Fang

et al.

Advanced Materials Technologies, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 14, 2024

Abstract For porous dressing production through 3D printing, it is challenging to adjust the printability of ink while balancing its bioactivity. The present study introduces an example a modular construction method for heterogeneous granular ink. Gelatin microspheres (gelatin‐MSs) are assembled by poly (gallic acid)‐coated zinc‐containing nano‐hydroxyapatite (ZnHA‐NP/p(GA)), and further cooperate with Ag + form kind inks. three modules including gelatin‐MS, ZnHA‐NP/p(GA), have their own functions: viscoelastic gelatin‐MS module essential component that realizes extrusion. ZnHA‐NP/p(GA) not only forms reversible interactions realize assembly but also takes responsibility reactive oxygen species‐scavenging anti‐inflammatory. interacts promote stability exhibits strong antibacterial property. size, p(GA)‐coating duration, content, content optimized yield nano‐micro bioactive preparation used significantly healing refractory wounds. Therefore, this allows particles different structures bio‐functions serve as assemble into inks, realizing balance biological functions manufacturing.

Language: Английский

High-resolution projection-based 3D bioprinting DOI
Chaofan He, Tianhong Qiao,

Guang-Hao Wang

et al.

Nature Reviews Bioengineering, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 27, 2024

Language: Английский

Citations

10
Bioprinting of Cells, Organoids and Organs-on-a-Chip Together with Hydrogels Improves Structural and Mechanical Cues DOI Creative Commons
Claudia Tanja Mierke

Cells, Journal Year: 2024, Volume and Issue: 13(19), P. 1638 - 1638

Published: Oct. 1, 2024

The 3D bioprinting technique has made enormous progress in tissue engineering, regenerative medicine and research into diseases such as cancer. Apart from individual cells, a collection of organoids, can be printed combination with various hydrogels. It hypothesized that will even become promising tool for mechanobiological analyses organoids their matrix environments highly defined precisely structured environments, which the mechanical properties cell environment individually adjusted. Mechanical obstacles or bead markers integrated bioprinted samples to analyze deformations forces within these constructs, perform biophysical analysis complex systems, are still not standard techniques. review highlights advances 4D printing technologies integrating cues so next step detailed key future directions organoid generation development disease model regeneration drug testing perspective. Finally, hydrogels, pure natural synthetic hydrogels mixtures, organoid–cell co-cultures, organ-on-a-chip systems organoid-organ-on-a chip combinations introduces use assembloids determine mutual interactions different types cell–matrix interferences specific biological environments.

Language: Английский

Citations

9
Advanced strategies in 3D bioprinting for vascular tissue engineering and disease modelling using smart bioinks DOI Creative Commons

Joeng Ju Kim,

Dong‐Woo Cho

Virtual and Physical Prototyping, Journal Year: 2024, Volume and Issue: 19(1)

Published: Aug. 30, 2024

Advanced three-dimensional (3D) bioprinting technology enables the precise production of complex vascular structures and biomimetic models, driving advancements in tissue engineering disease mechanism research. At core this is smart bioink, which suitable for fabricating models that can be vascularised to meet property requirements various tissues. Examples bioinks include decellularized extracellular matrix (dECM), photocrosslinkable, reversible, microgel-based biphasic (MB) bioinks, whose mechanical properties tuned through external stimuli. This tuning helps generate high-resolution complex-shaped networks essential cell survival functional maturation. review explores advanced 3D strategies using spatially controlled perfusable vitro emphasising reconstruction within bioprinted models. It also discusses challenges future prospects, suggesting could serve as alternatives traditional animal modelling drug screening.

Language: Английский

Citations

6
Graphene Oxide Modified Bioink for 3D-Bioprinting of Vascular Graft DOI

Irene Diez-Aldama,

Fátima García‐Villén, Laura Sáenz del Burgo

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 12, 2025

Three-dimensional bioprinting (3DBP) has emerged as a promising technique for fabricating complex tissue constructs using bioinks that support cell growth and differentiation. However, the mechanical properties of remain critical challenge in this area, particularly vascular applications. Herein, combination an inorganic (nano)material [graphene oxide (GO)] with organic material (collagen) possible ingredients bioink intended graft was explored. Different formulations were developed compared terms rheology, printability, ability to 3D scaffolds. The modified collagen GO exhibited improved viscoelastic control formulation. Additionally, showed full vitro biocompatibility, no signs cytotoxicity. With future applications mind, series scaffolds successfully bioprinted proposed bioink. coculture human endothelial cells muscle (C2C12) demonstrated its potential In short, work introduces developing grafts enhanced biological properties.

Language: Английский

Citations

0
From lab to life: advances in in-situ bioprinting and bioink technology DOI

Manish Kumar,

Payal Varma,

Balasubramanian Kandasubramanian

et al.

Biomedical Materials, Journal Year: 2024, Volume and Issue: 20(1), P. 012004 - 012004

Published: Dec. 20, 2024

Bioprinting has the potential to revolutionize tissue engineering and regenerative medicine, offering innovative solutions for complex medical challenges addressing unmet clinical needs. However, traditional

Language: Английский

Citations

1
Bioengineered Human Arterial Equivalent and Its Applications from Vascular Graft to In Vitro Disease Modeling DOI Creative Commons
Xi Luo, Z Pang, Jinhua Li

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(11), P. 111215 - 111215

Published: Oct. 19, 2024

Language: Английский

Citations

0
Nano‐Micro Granular Ink with Modulatable Structure and Function Modules for Wound Dressing Preparation via 3D Printing DOI
Tao Wang,

Dawei Niu,

Haowei Fang

et al.

Advanced Materials Technologies, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 14, 2024

Abstract For porous dressing production through 3D printing, it is challenging to adjust the printability of ink while balancing its bioactivity. The present study introduces an example a modular construction method for heterogeneous granular ink. Gelatin microspheres (gelatin‐MSs) are assembled by poly (gallic acid)‐coated zinc‐containing nano‐hydroxyapatite (ZnHA‐NP/p(GA)), and further cooperate with Ag + form kind inks. three modules including gelatin‐MS, ZnHA‐NP/p(GA), have their own functions: viscoelastic gelatin‐MS module essential component that realizes extrusion. ZnHA‐NP/p(GA) not only forms reversible interactions realize assembly but also takes responsibility reactive oxygen species‐scavenging anti‐inflammatory. interacts promote stability exhibits strong antibacterial property. size, p(GA)‐coating duration, content, content optimized yield nano‐micro bioactive preparation used significantly healing refractory wounds. Therefore, this allows particles different structures bio‐functions serve as assemble into inks, realizing balance biological functions manufacturing.

Language: Английский

Citations

0