Nanofiber‐based Multifunctional Microspheres for Rapid Hemostasis and Microorganism Removal of Water DOI Open Access
Qing Li, Lianxu Ye,

Yanqiu Leng

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 14(4)

Published: Dec. 11, 2024

Abstract Constructing hemostats capable of effectively controlling severe hemorrhage from irregular wounds presents significant challenges and imperatives. In this study, a novel approach is introduced using nanofibrous chitin microspheres (NCM) that are compressed to 60% strain (NCM‐60%) amplify their water‐initiated expansion performance. This unique capacity allows NCM‐60% efficiently conform fill bleeding cavities, even those varying depths curvatures, thereby promoting rapid blood coagulation at deep sites. exhibits effective control femoral artery “J”‐shaped liver hemorrhages in 151 ± 6 s 68 15 s, respectively, revealing its exceptional hemostatic efficacy. Furthermore, exhibited promising capabilities removing microbes water, achieving removal rates over 96% bacteria. Blood compatibility assessments cytotoxicity tests further confirmed the favorable biocompatibility NCM‐60%. Importantly, found biodegrade be absorbed vivo within 12 weeks. study represents first instance leveraging nanofiber‐based biomaterials design micro‐hemostat, integrate functions with waterborne microorganism removal, expanding potential applications micro‐nanostructural materials emergency first‐aid scenarios.

Language: Английский

Janus Nanofiber Membranes with Photothermal‐Enhanced Biofluid Drainage and Sterilization for Diabetic Wounds DOI
Xiaojing Zhang, Nuo Yu, Qian Ren

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(24)

Published: Feb. 16, 2024

Abstract Diabetic wounds are difficult to heal, and the key wound healing is exudate management effective disinfection. Inspired by asymmetric wettability of Janus‐structured lotus leaves, herein study has presented design a biomimetic Janus membrane that integrates unidirectional biofluid drainage photothermal‐enhanced evaporation/sterilization capabilities for accelerating diabetic healing. This prepared electrospinning polyacrylonitrile (PAN) nanofiber containing polydopamine (PDA) on surface polypropylene (PP) nonwoven membrane. Such PP/PAN x%PDA enables antigravity “pumping” water from hydrophobic PP layer hydrophilic PAN within 22 s through contact points interface. The incorporation 30 wt% PDA in imparts high photoabsorption photothermal responsiveness, facilitating continuous volatilization exudate, achieving twice displacement water, causing irreversible damage bacteria. As result, it effectively alleviates inflammation cellular fibrosis while promoting collagen deposition due its structure antibacterial properties. Impressively, such achieves an impressive closure rate 96.7% wounds, better than (59.8%) conventional bandages. Therefore, this offers promising alternative chronic wounds.

Language: Английский

Citations

65
Self-absorbing multilayer skin-like composite with Phyllostachys nigra polysaccharides promotes wound healing DOI
Kui Zhao, Luming Qi, Qi Li

et al.

Advanced Composites and Hybrid Materials, Journal Year: 2024, Volume and Issue: 7(6)

Published: Nov. 6, 2024

Language: Английский

Citations

23
Spatially engineering tri-layer nanofiber dressings featuring asymmetric wettability for wound healing DOI Creative Commons
Tingting Shi, Yuan Liu, Donghui Wang

et al.

Nano Materials Science, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Inspired by the skin structure, an asymmetric wettability tri-layer nanofiber membrane (TNM) consisting of hydrophilic inner layer loaded with lidocaine hydrochloride (LID), hydrophobic middle ciprofloxacin (CIP) and outer has been created. The endows TNM waterproof function anti-adhesion from contaminants. CIP preserves long-term inhibition bacteria growth LID possesses optimal water-absorbing capacity air permeability. dramatically elevates water contact angles 10° (inner layer) to 120° (outer layer), indicating wettability, which could directionally transport wound exudate within materials meanwhile maintain a comfortable moist environment promote healing. Furthermore, sequential release relieve pain rapidly achieve antibacterial effect in long run, respectively. In addition, shows superior biocompatibility towards L929 ​cells. vivo results show prevent infection, accelerate epithelial regeneration significantly This study indicates developed asymmetrical synergetic drug great potential as dressing clinical application.

Language: Английский

Citations

14
A macromolecular cross-linked alginate aerogel with excellent concentrating effect for rapid hemostasis DOI

Huanxuan Huang,

Shiyang Liao,

Dong Zhang

et al.

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 338, P. 122148 - 122148

Published: April 10, 2024

Language: Английский

Citations

14
Carbonized Cellulose Aerogel Derived from Waste Pomelo Peel for Rapid Hemostasis of Trauma‐Induced Bleeding DOI Creative Commons

Wenbing Wan,

Yang Feng,

Jiang Tan

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(19)

Published: March 13, 2024

Abstract Uncontrollable massive bleeding caused by trauma will cause the patient to lose a large amount of blood and drop body temperature quickly, resulting in hemorrhagic shock. This study aims develop hemostatic product for hemorrhage management. In this study, waste pomelo peel as raw material is chosen. It underwent processes carbonization, purification, freeze‐drying. The obtained carbonized (CPP) hydrophilic exhibits porous structure (nearly 80% porosity). water/blood absorption ratio significantly faster than commercial Gelfoam has similar capacity. addition, CPP showed water‐triggered shape‐recoverable ability. Moreover, shows ideal cytocompatibility compatibility vitro favorable tissue after long terms subcutaneous implantation. Furthermore, can absorb red cells fibrin. also platelets activate platelets, it capable achieving rapid hemostasis on rat tail amputation hepatectomized model. not only quickly stop liver‐perforation rabbit heart uncontrolled models, but promotes liver regeneration situ. These results suggest shown great potential managing hemorrhage.

Language: Английский

Citations

11
A poly (lactic-co-glycolic acid) self-pumping Janus dressing with bidirectional biofluid transport for diabetic wound healing via anti-bacteria and pro-angiogenesis DOI

Lisi Yan,

Yu Wang, Wenyuan Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 275, P. 133361 - 133361

Published: July 2, 2024

Language: Английский

Citations

4
SiO2-based inorganic nanofiber aerogel with rapid hemostasis and liver wound healing functions DOI
Jimin Huang, Yi Zheng,

Wenping Ma

et al.

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Bone Morphogenetic Protein-2–Derived Peptide-Conjugated Nanozyme-Integrated Photoenhanced Hybrid Hydrogel for Cascade-Regulated Bone Regeneration DOI

Jiaxin Chen,

Ye Zhao,

Renjie Ruan

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Critical-sized bone defects present a clinical challenge due to their limited self-repair capacity. Application of tissue-engineering scaffolds often overlooks the dynamic modulation microenvironment, resulting in unsatisfactory bone-regeneration outcomes. In this study, morphogenetic protein-2-derived peptide-loaded honeycomb manganese dioxide (BHM) nanozyme was incorporated into composite hydrogel (BHM@CG) composed l-arginine-modified methacrylated carboxymethyl chitosan and gallic acid-grafted gelatin. This demonstrated cascade-regulated enhancement hemostasis, antibacterial activity, anti-inflammatory effects, osteogenesis. Initially, BHM@CG achieved rapid hemostasis by quickly adhering irregular upon injury. Subsequently, it displayed robust activity through synergistic hydrogen bonding, hydrophobic interactions, cationic interactions. Meanwhile, BHM polyphenol groups from acid effectively eliminated reactive oxygen species, enabling long-term inflammation regulation. Finally, sustained release bioactive components promoted cell migration, angiogenesis, osteogenesis, achieving bone-formation rate nearly 40% critical-sized calvarial defect model week 8. More interestingly, also efficient capabilities an infected model. Overall, dynamically modulated bone-defect microenvironment enhanced regeneration, offering promising strategy for repair.

Language: Английский

Citations

0
Triple-layered core-shell fiber dressings with enduring platelet conservation and sustained growth factor release abilities for chronic wound healing DOI Creative Commons
Simin Lai,

Tingbin Wu,

Chenxi Shi

et al.

Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 11

Published: Jan. 1, 2024

Abstract Platelet-rich plasma (PRP) is one of the most popular biomaterials in regenerative medicine. However, difficulties encountered its preservation, and requirement for on-demand preparation severely limit application. In addition, rapid degradation wound microenvironment makes sustained release growth factors impossible finally reduces therapeutic effect on chronic wounds. Here, a multifunctional dressing based triple-layered core-shell fibers loading enduring preservation PRP was developed using one-step coaxial bioprinting technique combined with freeze-drying. The platelets were effectively dispersed immobilized core layer fiber, leading to from PRP. rate can be controlled by adjusting structure. Simultaneously, structure reduce deactivation during freezing storage. experimental findings suggest that exhibits activity, facilitating process healing even after storage period 180 days. Furthermore, protective mechanism fiber investigated, conditions freeze-drying optimized, further enhancing long-term storability As result, dressings this study offer novel approach factor active

Language: Английский

Citations

3
Zwitterion-Modified MXene Quantum Dot as a Nanocarrier for Traditional Chinese Medicine Sanguinarine Delivery and Its Application for Photothermal-Chemotherapy Synergistic Antibacterial and Wound Healing DOI
Fang Zhang,

Gaoqi Sun,

Rong Zhao

et al.

Langmuir, Journal Year: 2024, Volume and Issue: 40(22), P. 11381 - 11389

Published: May 22, 2024

The nanomaterialization of traditional Chinese medicine (TCM) has aroused widespread interest among researchers. Sanguinarine (SAN) is a kind TCM with good antibacterial properties, which important applications in anti-infection wounds. Additionally, the combination photothermal therapy and chemotherapy can overcome bacterial resistance, further improving bactericidal wound healing efficiency. In this paper, we prepared an agent by loading SAN on zwitterion-modified MXene quantum dot nanocarrier (SAN@AHEP@Ta

Language: Английский

Citations

3