THE EFFECT OF NANOPLASTICS AND MICROPLASTICS ON LUNG MORPHOLOGY AND PHYSIOLOGY: A SYSTEMATIC REVIEW DOI Creative Commons

Y.V. Rybalchenko

The Medical and Ecological Problems, Journal Year: 2024, Volume and Issue: 28(3), P. 42 - 60

Published: Dec. 30, 2024

Airborne microplastic (NP) and nanoplastic (MP) pollution has emerged as a pressing environmental concern with significant implications for human health. While MPs are present both indoors outdoors, indoor concentrations generally higher due to the abrasion of household materials, furniture, other domestic sources. NPs, when inhaled, accumulate in various lung regions, exerting toxic effects potentially leading respiratory diseases. This systematic review, conducted according PRISMA guidelines, evaluates recent experimental studies on pathogenic impact nanomicroplastics (NMPs) tissues using vivo vitro models. The review included 10 analyzing MP accumulation 90 examining pathogenetic mechanisms exposure. Research data indicates predominance polymeric fibers such polypropylene, polyethylene terephthalate, polytetrafluoroethylene, accounting nearly half structures. NMPs exhibit size- composition-dependent accumulation, smaller positively charged particles showing translocation potential systemic circulation organs. highlights synergistic heavy metals pollutants, interaction pulmonary surfactant, role exacerbating Current analysis underscores growing interest NMP-related health risks identifies knowledge gaps, including need standardization NMP toxicity testing further exploration biological systems. findings emphasize importance mitigating exposure safeguard pave way future research long-term impacts airborne

Language: Английский

The impaired response of nasal epithelial cells to microplastic stimulation in asthma and COPD DOI Creative Commons
Magdalena Paplińska‐Goryca, Paulina Misiukiewicz‐Stępień, Maria Wróbel

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 4, 2025

Microplastic particles from the air are inhaled and accumulate in lungs, potentially causing immunological reactions airway tissue injury. This study aimed to evaluate biological effects of polyamide fibres on nasal epithelium co-cultivated with macrophages control, asthma, COPD groups. Nasal epithelial cells alone or co-culture monocyte-derived were exposed for 48 h. We identified 8 differentially expressed genes (DEGs) controls, 309 DEGs asthma (including ANKRD36C, BCL2L15, FCGBP, IL-19), 22 (e.g., IL-19, CAPN14, PGBD5, PTPRH), particularly epithelial/moMφ co-cultures. exposure induced inflammatory cytokine secretion only IL-8 production controls (epithelial/ moMφs co-culture) asthmatic (monoculture) contrast PM2.5, which was a strong inducer. Gene Ontology analysis revealed that microplastic affected sterol cholesterol biosynthesis, secondary alcohol metabolism, acetyl-CoA metabolism cell motility, chemokine signaling, leukocyte migration, chemotaxis COPD. stimulation altered response obstructive lung diseases differently than linking Th2 inflammation, stress modulation, carcinogenesis. Asthmatic more susceptible damage fibre exposure.

Language: Английский

Citations

2
Microplastic environmental behavior and health risk assessment: a review DOI
Jialin Lei,

Qianwen Ma,

Xiaomeng Ding

et al.

Environmental Chemistry Letters, Journal Year: 2024, Volume and Issue: 22(6), P. 2913 - 2941

Published: Aug. 20, 2024

Language: Английский

Citations

14
A particle of concern: explored and proposed underlying mechanisms of microplastic-induced lung damage and pulmonary fibrosis DOI
R. K. Gautam,

Laltanpuia,

Nishant Singh

et al.

Inhalation Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17

Published: Feb. 11, 2025

In the past decade, microplastics (MPs) have drawn significant attention as widespread environmental contaminants, with research increasingly highlighting their harmful effects on respiratory health in aquatic and terrestrial organisms. Findings revealed human lung tissues, raising concerns about potential role damaging tissue integrity contributing to pulmonary fibrosis-a chronic inflammatory condition characterized by scarring of epithelial tissues due accumulated extracellular matrix, triggered factors such alcohol, pathogens, genetic mutations, pollutants. this review, we explore both well-studied lesser-studied mechanisms signaling pathways, aiming shed light how might act mediators that activate distinct, often overlooked cascades. This review searched PubMed Google Scholar using keywords like "plastic," "microplastic," "lung fibrosis," "pulmonary system," "exposure route," "signaling pathways," combined "OR" "AND" singular plural forms. These pathways could not only induce damage but also play a development fibrosis. be targeted reduce microplastic-induced fibrosis, opening new avenues for future treatments.

Language: Английский

Citations

1
Blood-brain barrier damage accelerates the accumulation of micro- and nanoplastics in the human central nervous system DOI
Jian Xie,

Jiale Ji,

Yun Sun

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 136028 - 136028

Published: Oct. 2, 2024

Language: Английский

Citations

8
Microplastics in Indonesian land and aquatic environment: From research activities to regulation policies DOI

Nadia Nurani Isfarin,

Meita Eka Fara,

Heru Nur Krisna

et al.

Marine Pollution Bulletin, Journal Year: 2024, Volume and Issue: 206, P. 116813 - 116813

Published: Aug. 7, 2024

Language: Английский

Citations

6
Insight into the Size Markers and Eco-Health Significance of Microplastics and Plasticizers from Typical Sources in Northwest China DOI
Liyan Liu,

Hongmei Xu,

Mengyun Yang

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Deep learning-driven behavioral analysis reveals adaptive responses in Drosophila offspring after long-term parental microplastic exposure DOI
Chuanyong Wang, Jie Shen

Journal of Environmental Management, Journal Year: 2025, Volume and Issue: 376, P. 124502 - 124502

Published: Feb. 15, 2025

Language: Английский

Citations

0
Role of microplastics in the tumor microenvironment (Review) DOI Open Access
Yunjie Chen, Zihang Zhang,

Kangming Ji

et al.

Oncology Letters, Journal Year: 2025, Volume and Issue: 29(4), P. 1 - 14

Published: Feb. 21, 2025

Microplastics (MPs) are pervasive in several ecosystems and have the potential to infiltrate multiple aspects of human life through ingestion, inhalation dermal exposure, thus eliciting substantial concerns regarding their implications for health. Whilst initial research has documented effects MPs on disease development across physiological systems, may also facilitate tumor progression by influencing microenvironment (TME). This evolving focus underscores growing interest role tumorigenesis interactions within TME. In present review, relationship between TME is comprehensively assessed, providing a detailed analysis with cells, stromal cells (including macrophages, fibroblasts endothelial cells), extracellular matrix inflammatory processes. Recommendations future directions strategies address reduce microplastic pollution proposed.

Language: Английский

Citations

0
Biological Effects of Micro-/Nano-Plastics in Macrophages DOI Creative Commons
Massimiliano G. Bianchi, Lavinia Casati,

Giulia Sauro

et al.

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(5), P. 394 - 394

Published: March 4, 2025

The environmental impact of plastics is worsened by their inadequate end-of-life disposal, leading to the ubiquitous presence micro- (MPs) and nanosized (NPs) plastic particles. MPs NPs are thus widely present in water air inevitably enter food chain, with inhalation ingestion as main exposure routes for humans. Many recent studies have demonstrated that gain access several body compartments, where they taken up cells, increase production reactive oxygen species, lead inflammatory changes. In most tissues, resident macrophages engage first approach foreign materials, this interaction largely affects subsequent fate material possible pathological outcomes. On other hand, organizers controllers both responses tissue repair. Here, we aim summarize available information on NPs. Particular attention will be devoted consequences macrophage viability functions, well implications pathology.

Language: Английский

Citations

0
Ferroptosis involved in inhaled polystyrene microplastics leaded myocardial fibrosis through HIF-ROS-SLC7A11/GPX4 Pathway DOI
Danyang Huang,

Huiwen Kang,

Ziyan Liu

et al.

Journal of Environmental Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0