Microplastics in the Human Body: Exposure, Detection, and Risk of Carcinogenesis: A State-of-the-Art Review

Cancers, Journal Year: 2024, Volume and Issue: 16(21), P. 3703 - 3703

Published: Nov. 1, 2024

Humans cannot avoid plastic exposure due to its ubiquitous presence in the natural environment. The waste generated is poorly biodegradable and exists form of MPs, which can enter human body primarily through digestive tract, respiratory or damaged skin accumulate various tissues by crossing biological membrane barriers. There an increasing amount research on health effects MPs. Most literature reports focus impact plastics respiratory, digestive, reproductive, hormonal, nervous, immune systems, as well metabolic MPs accumulation leading epidemics obesity, diabetes, hypertension, non-alcoholic fatty liver disease. xenobiotics, undergo ADMET processes body, i.e., absorption, distribution, metabolism, excretion, are not fully understood. Of particular concern carcinogenic chemicals added during manufacturing adsorbed from environment, such chlorinated paraffins, phthalates, phenols, bisphenols, be released when absorbed body. continuous increase NMP has accelerated SARS-CoV-2 pandemic there was a need use single-use products daily life. Therefore, urgent diagnose problems related MP detection.

Language: Английский

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FGF1 alleviates polystyrene nanoplastics-induced neuroinflammation through the suppression of lipophagy

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 302, P. 140531 - 140531

Published: Jan. 30, 2025

Language: Английский

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Effects of microplastics on the immune system: How much should we worry?

Immunology Letters, Journal Year: 2025, Volume and Issue: 272, P. 106976 - 106976

Published: Feb. 1, 2025

Plastics are everywhere. It is widely recognized that they represent a global problem, the extent of which yet to be defined. Humans broadly exposed plastics, whose effects and consequences poorly characterized so far. The main route exposure via alimentary respiratory intake. pollutions may come from both: water food contamination itself, their packaging. smaller sizes (i.e. microplastics <150 µm - MPs) considered most pervasive living organisms and, therefore, potentially harmful. As humans occupy one apex positions chain, we bioaccumulation biomagnification MPs. In fact, MPs commonly found in human stools blood. However, there no data available on ability accumulate produce detrimental biological systems. Even though plastics pollution studied mammals, including humans, appear have inflammatory effects, rather concerning as many etiologies disease based pro-inflammatory status.

Language: Английский

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Identification and Characterization of Microplastics in Human Cervicovaginal Lavage Fluids Using Raman Spectroscopy: A Preliminary Study

Life, Journal Year: 2025, Volume and Issue: 15(3), P. 357 - 357

Published: Feb. 24, 2025

Microplastics have been detected in various human organs, and studies on their impact health are ongoing. However, few researched microplastics the cervicovaginal area. In this study, we aimed to assess presence lavage fluid. This prospective study was conducted at a single tertiary medical center, enrolling 10 participants aged 27–49 years. Human fluid samples were collected from patients by skilled obstetrician. Raman spectroscopy used analyze characterize microplastic particles samples. Ninety-one More than 50% of identified patient who regularly menstrual cups. The mean number 9.10 ± 14.96 per g sample. Most <50 μm size, polypropylene polystyrene most predominant types. analysis fluids, suggesting that area is exposed microplastics. varied significantly among individuals. highlights need for further research effects female reproductive system using

Language: Английский

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Neurotoxicity Following Exposure to Micro and Nanoplastics

OBM Neurobiology, Journal Year: 2025, Volume and Issue: 09(01), P. 1 - 20

Published: March 16, 2025

The pervasive presence and enduring existence of micro nanoplastics in the environment render their exposure to humans aquatic creatures unavoidable. Research indicates these tiny plastic particles can be taken by beings mammals. Once within body, have capability infiltrate brain, although level penetration subsequent neurotoxic effects are not fully explored. Previous studies indicate that metal (oxide) nanoparticles enter brain induce effects. Given chemical resemblances between inert nanoparticles, this review aims summarize existing on implications across various species vitro settings. current evidence, incomplete, suggests may lead oxidative stress, potentially causing cell damage raising risk developing neurological disorders. Moreover, such could inhibit acetylcholinesterase activity alter neurotransmitter levels, contributing observed behavioral changes. There is a notable lack systematic comparison regarding stemming from different particle types, shapes, sizes at concentrations durations exposure. Understanding aspects essential for further evaluating danger associated with nanoplastics.

Language: Английский

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Association between microplastics exposure and depressive symptoms in college students

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 295, P. 118142 - 118142

Published: April 1, 2025

Microplastics (MP) are pervasive environmental pollutants that have raised concerns regarding their potential health effects. However, limited studies investigated the relationship between MP exposure and depression, particularly in college students. Our study aims to examine association depressive symptoms A total of 1420 students from Jiangsu College Nursing, China, were included this cross-sectional study. Depressive assessed using Patient Health Questionnaire-2 (PHQ-2), was estimated based on daily airborne concentration drinking-water levels. Multivariate logistic regression models used estimate associations symptoms. The prevalence among 61.8 %. median (interquartile range) 17403.7 (14174.8-20995.9) particles/day. Airborne exhibited positive with symptoms, while no significant found Compared participants lowest quartile exposure, those highest had 38 % higher odds experiencing (odds ratio [OR] = 1.38, 95 CI: 1.21-1.57). When treated as a continuous variable, each 1000-particle increase associated 7.0 (OR 1.07, 1.04-1.10). Stratified analyses indicated stronger male freshmen. This suggests is contributing factor for

Language: Английский

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Functionalized Nanoparticles: A Promising Approach for Effective Management of Alzheimer’s Disease

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Language: Английский

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Microplastics/nanoplastics and Neurological Health: An Overview of Neurological Defects and Mechanisms

Toxicology, Journal Year: 2024, Volume and Issue: 511, P. 154030 - 154030

Published: Dec. 7, 2024

Language: Английский

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