Advances in Nanostructured Metallic Materials—A Pathway to Future Innovations DOI Creative Commons
Marek Wojnicki, Marc Escribà‐Gelonch, Volker Hessel

et al.

Metals, Journal Year: 2024, Volume and Issue: 14(11), P. 1237 - 1237

Published: Oct. 29, 2024

The development of civilization has always been deeply intertwined with advancements in metallurgy [...]

Language: Английский

Hydrogels and Nanogels: Pioneering the Future of Advanced Drug Delivery Systems DOI Creative Commons
Ernesto J. Delgado-Pujol, Guillermo Martínez,

David Casado-Jurado

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 215 - 215

Published: Feb. 7, 2025

Conventional drug delivery approaches, including tablets and capsules, often suffer from reduced therapeutic effectiveness, largely attributed to inadequate bioavailability difficulties in ensuring patient adherence. These challenges have driven the development of advanced systems (DDS), with hydrogels especially nanogels emerging as promising materials overcome these limitations. Hydrogels, their biocompatibility, high water content, stimuli-responsive properties, provide controlled targeted release. This review explores evolution, classifications versus applications delivery, detailing synthesis methods, chemical crosslinking, physical self-assembly, techniques such microfluidics 3D printing. It also examines drug-loading mechanisms (e.g., encapsulation electrostatic interactions) release strategies diffusion, stimuli-responsive, enzyme-triggered). gels demonstrate significant advantages addressing limitations traditional DDS, offering improved stability, sustained release, specificity. Their adaptability extends various routes administration, topical, oral, injectable forms, while further enhance targeting through nanoscale precision stimuli responsiveness. Although transformative potential personalized medicine, remain scalable manufacturing, regulatory approval, delivery. Future include integrating biosensors for real-time monitoring, developing dual-stimuli-responsive systems, optimizing surface functionalization advancements aim establish cornerstones next-generation solutions, revolutionizing paving way innovative, patient-centered treatments.

Language: Английский

Citations

5
A Review of Advanced Hydrogel Applications for Tissue Engineering and Drug Delivery Systems as Biomaterials DOI Creative Commons
Hoon Choi, Wan-Sun Choi,

Jin-Oh Jeong

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(11), P. 693 - 693

Published: Oct. 25, 2024

Hydrogels are known for their high water retention capacity and biocompatibility have become essential materials in tissue engineering drug delivery systems. This review explores recent advancements hydrogel technology, focusing on innovative types such as self-healing, tough, smart, hybrid hydrogels, each engineered to overcome the limitations of conventional hydrogels. Self-healing hydrogels can autonomously repair structural damage, making them well-suited applications dynamic biomedical environments. Tough designed with enhanced mechanical properties, enabling use load-bearing cartilage regeneration. Smart respond external stimuli, including changes pH, temperature, electromagnetic fields, ideal controlled release tailored specific medical needs. Hybrid made from both natural synthetic polymers, combine bioactivity resilience, which is particularly valuable complex tissues. Despite these innovations, challenges optimizing biocompatibility, adjusting degradation rates, scaling up production remain. provides an in-depth analysis emerging technologies, highlighting transformative potential while outlining future directions development applications.

Language: Английский

Citations

10
A review of chitosan-based multifunctional nanocomposites for drug/gene/protein delivery and gene therapy in cancer treatments: Promises, challenges and outlooks DOI
Ali Khorasani, Seyed Morteza Naghib

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141394 - 141394

Published: Feb. 1, 2025

Language: Английский

Citations

1
Advanced Hydrogel Systems for Local Anesthetic Delivery: Toward Prolonged and Targeted Pain Relief DOI Creative Commons

Jin-Oh Jeong,

Min-Joo Kim,

Seonwook Kim

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(2), P. 131 - 131

Published: Feb. 12, 2025

Local anesthetics (LAs) have been indispensable in clinical pain management, yet their limitations, such as short duration of action and systemic toxicity, necessitate improved delivery strategies. Hydrogels, with biocompatibility, tunable properties, ability to modulate drug release, extensively explored platforms for enhancing LA efficacy safety. This narrative review explores the historical development LAs, physicochemical applications, providing a foundation understanding integration hydrogels anesthetic delivery. Advances thermoresponsive, stimuli-responsive, multifunctional demonstrated significant potential prolonging analgesia reducing exposure preclinical studies, while early findings highlight feasibility thermoresponsive hydrogel formulations. Despite these advancements, challenges burst mechanical instability, regulatory considerations remain critical barriers translation. Emerging innovations, including nanocomposite hydrogels, biofunctionalized matrices, smart materials, offer solutions limitations. Future research should focus on optimizing formulations, expanding validation, integrating advanced fabrication technologies 3D printing artificial intelligence-driven design enhance personalized management. By bridging materials science pharmacology, this provides comprehensive perspective current trends future directions hydrogel-based systems.

Language: Английский

Citations

0
An In-Depth Review of Corrosion Pathways in Titanium Dental and Orthopedic Implants and Their Biological Interactions DOI
Hala Hrir, Abderrazzak Boudouma, Omar Ait Layachi

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Language: Английский

Citations

0
Recent progress of nanomaterials-based composite hydrogel sensors for human–machine interactions DOI Creative Commons

Yu-Yang Lin,

Aoli Wu, Yitao Zhang

et al.

Discover Nano, Journal Year: 2025, Volume and Issue: 20(1)

Published: March 29, 2025

Abstract Hydrogel-based flexible sensors have demonstrated significant advantages in the fields of electronics and human–machine interactions (HMIs), including outstanding flexibility, high sensitivity, excellent conductivity, exceptional biocompatibility, making them ideal materials for next-generation smart HMI sensors. However, traditional hydrogel still face numerous challenges terms reliability, multifunctionality, environmental adaptability, which limit their performance complex application scenarios. Nanomaterial-based composite hydrogels significantly improve mechanical properties, multifunctionality by incorporating conductive nanomaterials, thereby driving rapid development wearable HMIs. This review systematically summarizes latest research progress on based carbon metal two-dimensional MXene provides a comprehensive analysis sensing mechanisms HMI, triboelectric nanogenerator mechanism, stress-resistance response electrophysiological acquisition mechanism. The further explores applications hydrogel-based personal electronic device control, virtual reality/augmented reality (VR/AR) game interaction, robotic control. Finally, current technical status future directions nanomaterial are summarized. We hope that this will provide valuable insights inspiration design nanocomposite applications.

Language: Английский

Citations

0
A Highly Sensitive, Low Creep Hydrogel Sensor for Plant Growth Monitoring DOI Creative Commons

Haoyan Xu,

Guangyao Zhang,

Wensheng Wang

et al.

Sensors, Journal Year: 2024, Volume and Issue: 24(19), P. 6197 - 6197

Published: Sept. 25, 2024

Ion−conducting hydrogels show significant potential in plant growth monitoring. Nevertheless, traditional ionic hydrogel sensors experience substantial internal creep and inadequate sensitivity, hindering precise In this study, we developed a flexible sensor composed of polyvinyl alcohol acrylamide. The exhibits low high sensitivity. Polyvinyl alcohol, acrylamide, glycerol are crosslinked to create robust interpenetrating double network structure. strong interactions, such as van der Waals forces, between the networks minimize under external stress, reducing drift ratio by 50% rate more than 60%. Additionally, sodium chloride AgNWs enrich with conductive ions pathways, enhancing sensor’s conductivity demonstrating excellent response time (0.4 s) recovery (0.3 s). When used for monitoring, sensitivity small strains stability long−term This establishes foundation developing health monitoring systems utilizing renewable biomass materials.

Language: Английский

Citations

1
Preparation of Alginate Hydrogel Beads on a Superhydrophobic Surface with Calcium Salt Powder to Enhance the Mechanical Strength and Encapsulation Efficiency of Ingredients DOI Open Access

Y Hosokawa,

Takashi Goshima,

Takami Kai

et al.

Materials, Journal Year: 2024, Volume and Issue: 17(24), P. 6027 - 6027

Published: Dec. 10, 2024

Calcium alginate hydrogel is one of the most widely used materials for drug-carrier beads in drug-delivery systems. In this study, we developed a new method to improve encapsulation efficiency ingredients, such as medicines, calcium beads. gold standard method, are prepared liquid phase. contrast, enhance efficiency, gas phase using water-repellent surface. brief, droplet sodium aqueous solution rolled on surface with CaCl

Language: Английский

Citations

1
Advances in Nanostructured Metallic Materials—A Pathway to Future Innovations DOI Creative Commons
Marek Wojnicki, Marc Escribà‐Gelonch, Volker Hessel

et al.

Metals, Journal Year: 2024, Volume and Issue: 14(11), P. 1237 - 1237

Published: Oct. 29, 2024

The development of civilization has always been deeply intertwined with advancements in metallurgy [...]

Language: Английский

Citations

0