Chitosan-Based Gel Development: Extraction, Gelation Mechanisms, and Biomedical Applications DOI Creative Commons
Nicoleta Mirela Blebea, Ciprian Pușcașu, Robert-Alexandru Vlad

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(4), P. 275 - 275

Published: April 6, 2025

Chitosan (CS), a versatile biopolymer obtained through the deacetylation of chitin, has gained significant interest in biomedical and pharmaceutical applications due to its biocompatibility, biodegradability, unique gel-forming capabilities. This review comprehensively analyzes CS-based gel development, covering extraction from various natural sources, gelation mechanisms, applications. Different methods, including chemical, biological, green techniques, are discussed regarding efficiency sustainability. The explores physicochemical properties CS that influence behavior, highlighting mechanisms such as physical, ionic, chemical cross-linking. Recent advances formation, Schiff base reactions, Diels–Alder click chemistry, thermosensitive gelation, have expanded applicability hydrogels. Furthermore, gels demonstrated potential wound healing, tissue engineering, drug delivery, antimicrobial applications, offering controlled release, enhanced tunable mechanical properties. incorporation nanomaterials, bioactive molecules, functional cross-linkers further improved hydrogel performance. current underscores growing significance innovative biomaterials regenerative medicine sciences.

Language: Английский

Chitosan-Based Gel Development: Extraction, Gelation Mechanisms, and Biomedical Applications DOI Creative Commons
Nicoleta Mirela Blebea, Ciprian Pușcașu, Robert-Alexandru Vlad

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(4), P. 275 - 275

Published: April 6, 2025

Chitosan (CS), a versatile biopolymer obtained through the deacetylation of chitin, has gained significant interest in biomedical and pharmaceutical applications due to its biocompatibility, biodegradability, unique gel-forming capabilities. This review comprehensively analyzes CS-based gel development, covering extraction from various natural sources, gelation mechanisms, applications. Different methods, including chemical, biological, green techniques, are discussed regarding efficiency sustainability. The explores physicochemical properties CS that influence behavior, highlighting mechanisms such as physical, ionic, chemical cross-linking. Recent advances formation, Schiff base reactions, Diels–Alder click chemistry, thermosensitive gelation, have expanded applicability hydrogels. Furthermore, gels demonstrated potential wound healing, tissue engineering, drug delivery, antimicrobial applications, offering controlled release, enhanced tunable mechanical properties. incorporation nanomaterials, bioactive molecules, functional cross-linkers further improved hydrogel performance. current underscores growing significance innovative biomaterials regenerative medicine sciences.

Language: Английский

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