International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 139236 - 139236
Published: Dec. 1, 2024
Language: Английский
Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 24, 2025
The COVID-19 pandemic underscored bacterial resistance as a critical global health issue, exacerbated by the increased use of antibiotics during crisis. Notwithstanding pandemic's prevalence, initiatives to address medication have been inadequate. Although an overall drop in worldwide antibiotic consumption, total usage remains substantial, requiring rigorous regulatory measures and preventive activities mitigate emergence resistance. National Action Plans (NAPs) implemented worldwide, significant disparities persist, particularly low- middle-income countries (LMICs). Settings such farms, hospitals, wastewater treatment facilities, agricultural environments include presence Antibiotic Resistant Bacteria (ARB) antibiotic-resistance genes (ARG), promoting propagation Dietary modifications probiotic supplementation shown potential reshaping gut microbiota reducing gene prevalence. Combining with adjuvants or bacteriophages may enhance efficacy development. Novel therapeutic approaches, tailored antibiotics, monoclonal antibodies, vaccines, nanoparticles, offer alternate ways addressing In spite advancements next-generation sequencing analytics, gaps persist comprehending role regulating Effectively tackling requires robust policy interventions targeting root causes while minimizing public risks. This review provides information for developing strategies protocols prevent colonization, microbiome resilience, spread
Language: Английский
Citations
2
BMC Biotechnology, Journal Year: 2024, Volume and Issue: 24(1)
Published: May 4, 2024
Abstract Scientists know very little about the mechanisms underlying fish skin mucus, despite fact that it is a component of immune system. Fish mucus an important defence against invasive infections. Recently, and its are gaining interest among immunologists. Characterization was done on obtained silver nanoparticles Ag combined with Clarias gariepinus catfish epidermal proteins (EMP-Ag-NPs) through UV–vis, FTIR, XRD, TEM, SEM. Ag-NPs ranged in size from 4 to 20 nm, spherical form angles were 38.10°, 44.20°, 64.40°, 77.20°, Where wavelength change after formation EMP-Ag-NPs as indicate dark brown, broad band recorded at 391 nm. Additionally, antimicrobial, antibiofilm anticancer activities assessed. The present results demonstrate high activity unicellular fungi C. albicans , followed by E. faecalis . Antibiofilm showed strong both S. aureus P. aeruginosa pathogens dose-dependent manner, without affecting planktonic cell growth. Also, cytotoxicity effect investigated normal cells (Vero), breast cancer (Mcf7) hepatic carcinoma (HepG2) lines concentrations (200–6.25 µg/mL) current highly 100, 5 25 µg/mL exhibited rounding, shrinkage, deformation granulation Mcf7 HepG2 IC50 19.34 31.16 respectively while Vero appeared rounded concentration 50 shape 25, 12.5 6.25 µg/ml 35.85 µg/mL. This study evidence potential efficacy biologically generated substitute medicinal agent harmful microorganisms. Furthermore, highlights their inhibitory lines.
Language: Английский
Citations
11
Antibiotics, Journal Year: 2024, Volume and Issue: 13(7), P. 648 - 648
Published: July 13, 2024
Antimicrobial resistance is a global threat that requires urgent attention to slow the spread of resistant pathogens. The United States Centers for Disease Control and Prevention (CDC) has emphasized clinician-driven antimicrobial stewardship approaches including reporting proper documentation usage resistance. Additional efforts have targeted development new agents, but narrow profit margins hindered manufacturers from investing in novel antimicrobials clinical use therefore production antibiotics decreased. In order combat this, both drug discovery processes healthcare reimbursement programs must be improved. Without action, this poses high probability culminate deadly post-antibiotic era. This review will highlight some health challenges faced today future. Furthermore, Infectious Diseases Society America (IDSA) guidelines Gram-negative pathogens discussed. includes agents which gained or are likely gain FDA approval. Emphasis placed on human each these cover, as well how could utilized practice.
Language: Английский
Citations
5
Ceramics International, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Language: Английский
Citations
0
Journal of Hazardous Materials Advances, Journal Year: 2025, Volume and Issue: unknown, P. 100690 - 100690
Published: March 1, 2025
Language: Английский
Citations
0
Antibiotics, Journal Year: 2024, Volume and Issue: 13(3), P. 232 - 232
Published: Feb. 29, 2024
Antimicrobial resistance (AMR) poses a global threat, leading to increased mortality and necessitating urgent action—however, its impact on athletes the world of sports has hitherto been neglected. Sports environments (including athletic aquatic) exhibit high levels microbial contamination, potentially contributing spread resistant microorganisms during physical activities. Moreover, literature suggests that travel for events may lead changes in athletes’ gut microbiomes their antibiotic profiles, raising questions about broader implications individual public/global health. The prevalence Staphylococcus aureus (S. aureus) among (particularly those engaged contact or collision sports) ranges between 22.4% 68.6%, with MRSA strains being isolated up 34.9% tested individuals. Factors such as training frequency, equipment sharing, delayed post-training showers, history certain medical conditions are linked higher colonization rates. outbreaks have documented teams previously, highlighting importance implementing preventive measures hygiene protocols settings. In light growing threat AMR, there is critical need evidence-based treatment guidelines tailored unique physiological demands ensure responsible use mitigate potential health risks. While various initiatives—such incorporating AMR awareness into major sporting events—aim leverage broad audience communicate addressing proactive improved surveillance large events) will be indispensable enhancing preparedness safeguarding both general public’s This narrative review thoroughly assesses existing usage context sports, aiming illuminate areas where information lacking underscoring significance promoting through sports.
Language: Английский
Citations
0
Journal of Biomedical Translational Research, Journal Year: 2024, Volume and Issue: 25(2), P. 89 - 99
Published: June 1, 2024
Language: Английский
Citations
0
Lecture notes in computer science, Journal Year: 2024, Volume and Issue: unknown, P. 172 - 185
Published: Jan. 1, 2024
Language: Английский
Citations
0
Vector-Borne and Zoonotic Diseases, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 15, 2024
Background: Researchers paid more attention to nosocomial Acinetobacter baumannii in veterinary hospitals worldwide; however, the research scope toward community-acquired A. infections among animals is largely ignored. Therefore, current study aimed investigate role of diseased dogs and cats suffering from respiratory illness transmission infection its public health threat.
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 139236 - 139236
Published: Dec. 1, 2024
Language: Английский
Citations
0