Journal of Heterocyclic Chemistry,
Journal Year:
2022,
Volume and Issue:
60(4), P. 537 - 565
Published: Oct. 13, 2022
Abstract
Among
different
heterocyclic
compounds,
isoxazole
and
their
analogues
are
very
important
classes
of
compounds
as
they
display
an
extensive
range
biological
actions.
This
makes
such
scaffolds
structures
in
the
field
medicinal
chemistry.
From
literature
assessment,
is
clinically
proven
to
be
effective
anti‐bacterial,
anti‐fungal,
anti‐inflammatory,
anti‐cancer,
anti‐tubercular,
anti‐neoplastic
agent.
The
derivatives
which
exhibits
adjustment
structure
have
shown
a
high
degree
variety
properties
evident
them
beneficial
progress
novel
bioactive
drugs
show
enhanced
effectiveness
along
with
minor
harmfulness.
Structural
aspects
having
aromaticity
weaker
nitrogen‐oxygen
bonding
provide
potential
site
for
ring
cleavage.
Thus,
this
system
allows
easier
modifications
substituents
consequently
make
useful
intermediates
various
synthetic
routes
compounds.
Hence,
synthesis
evaluation
isoxazole‐containing
molecules
wider
therapeutic
consequences
always
topic
interest
chemists.
light
comprehensive
research
on
isoxazole,
it
thought
worthwhile
review
pathways
broad
spectrum
Current Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
27(17), P. 1504 - 1530
Published: Sept. 1, 2023
Abstract:
Dess-Martin
periodinane
(DMP)
is
one
of
the
hypervalent
iodines
that
most
frequently
utilized
as
an
oxidizing
agent
in
organic
chemistry.
The
authors
this
septennial
review
have
critically
and
methodically
presented
representative
applications
DMP
synthesis
from
2015
to
present,
including
oxidations,
dehydrogenations,
hetero
homo-dimerizations,
aromatizations,
thiocyanations,
halogenations,
dearylations,
ring
expansions,
cyclizations,
heterocyclic
formation,
other
miscellaneous
reactions.
This
discusses
range
constraints
these
transformations.
ChemistrySelect,
Journal Year:
2022,
Volume and Issue:
7(10)
Published: March 14, 2022
Abstract
A
tangible
substituent
effect
may
be
perceived
as
a
good
feature
in
developing
an
organic
reaction.
This
work
demonstrates
that,
on
the
contrary,
zero‐slope
Hammet
plot
should
sought.
The
synthesis
of
isoxazoles
by
consecutive
cycloaddition
nitrile
oxides
to
vinyl
ethers
and
alcohols
elimination
was
studied
computationally
experimentally.
We
performed
Hammett
study
silico
demonstrate
negligible
(i.
e.,
broad
substrate
scope)
addition
benzyl
ether
oxides.
modeling
at
ωB97X‐V/def2‐TZVP//PBE0‐D4/def2‐TZVP+SMD(benzene)
level
theory
within
RIJCOSX
approximation.
experimental
evaluation
validated
computational
model.
versatile
methodology
for
synthesizing
substituted
isoxazolines
proposed
main
result.
present
this
successful
example
how
quantum
chemical
can
re‐boost
classic
approach
optimization
design
synthetic
methodologies.
anticipate
further
studies
,
considering
current
trend
data‐driven
research.
Bulletin of the Chemical Society of Japan,
Journal Year:
2019,
Volume and Issue:
92(9), P. 1447 - 1449
Published: June 14, 2019
N-Acyl
isoxazolidines
were
obtained
in
moderate
to
good
yields
by
intramolecular
hydroamination
of
N-alkoxyamides
the
presence
a
ruthenium
photocatalyst.
In
this
reaction,
N-alkoxyamide
a...
Beilstein Journal of Organic Chemistry,
Journal Year:
2020,
Volume and Issue:
16, P. 1313 - 1319
Published: June 16, 2020
Isoxazolidines
represent
a
very
important
class
of
N/O-containing
heterocycles
used
as
the
key
intermediates
in
synthesis
more
complex
cyclic
and
acyclic
compounds,
including
various
biologically
active
molecules.
Here,
we
present
fast
highly
stereoselective
approach
towards
both
C-3/4-cis
C-3/4-trans
isomers
3-substituted
isoxazolidin-4-ols.
The
strategy
relies
on
regio-
trans-stereoselective
hydroboration-oxidation
reaction
4,5-unsubstituted
2,3-dihydroisoxazoles
with
basic
hydrogen
peroxide.
consecutive
oxidation/reduction
route,
sequentially
employing
Dess-Martin
periodinane
ʟ-selectride,
is
for
inversion
relative
configuration
isoxazolidine
ring.
significance
method
lies
its
variability
applicability
to
concise
4-hydroxyisoxazolidines,
starting
from
readily
available
C-alkyl/aryl-nitrones.
resemblance
3-hydroxypyrrolidines
certainly
makes
4-hydroxyisoxazolidines
valuable
structural
fragments
drug
discovery.
