Amyotrophic lateral sclerosis caused by TARDBP mutations: from genetics to TDP-43 proteinopathy
The Lancet Neurology,
Journal Year:
2025,
Volume and Issue:
24(5), P. 456 - 470
Published: April 16, 2025
Language: Английский
Probiotics as Potential Treatments for Neurodegenerative Diseases: a Review of the Evidence from in vivo to Clinical Trial
Biomolecules & Therapeutics,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 16, 2024
Neurodegenerative
diseases
(NDDs),
characterized
by
the
progressive
deterioration
of
structure
and
function
nervous
system,
represent
a
significant
global
health
challenge.Emerging
research
suggests
that
gut
microbiota
plays
critical
role
in
regulating
neurodegeneration
via
modulation
gut-brain
axis.Probiotics,
defined
as
live
microorganisms
confer
benefits
to
host,
have
garnered
attention
owing
their
therapeutic
potential
NDDs.This
review
examines
current
trends
related
microbiome-gut-brain
axis
across
various
NDDs,
highlighting
key
findings
implications.Additionally,
effects
specific
probiotic
strains,
including
Lactobacillus
plantarum,
Bifidobacterium
breve,
rhamnosus,
on
neurodegenerative
processes
were
assessed,
focusing
benefits.Overall,
this
emphasizes
probiotics
promising
agents
for
underscoring
importance
further
investigation
into
emerging
field.
Language: Английский
DNA methylation in amyotrophic lateral sclerosis: where do we stand and what is next?
Epigenomics,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 12
Published: Sept. 11, 2024
Genes
involved
in
immune
response,
inflammation
and
metabolism
are
among
those
most
likely
affected
by
changes
DNA
methylation
(DNAm)
expression
levels
amyotrophic
lateral
sclerosis
(ALS)
tissues.
Unfortunately,
it
is
still
largely
unclear
whether
any
of
these
precede
the
onset
disease
symptoms
or
them
result
muscular
metabolic
that
follow
onset.
In
this
article
author
discusses
strengths
limitations
available
studies
DNAm
ALS
provides
some
suggestions
on
what,
his
opinion,
could
be
done
near
future
for
a
better
understanding
occurring
ALS,
their
link
with
environmental
exposures
potential
clinical
utility.
Language: Английский
The spectrum of behavioral disorders in amyotrophic lateral sclerosis: current view
Journal of Neural Transmission,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 14, 2024
Language: Английский
Research progress of brain-computer interface applied in the rehabilitation of dysarthria and speech function in amyotrophic lateral sclerosis
Deleted Journal,
Journal Year:
2024,
Volume and Issue:
1(4), P. 87 - 92
Published: Dec. 1, 2024
With
the
development
of
brain
science
research,
artificial
intelligence
technologies
such
as
brain-computer
interface
(BCI)
have
begun
to
be
applied
in
medical
field.
People
with
advanced
amyotrophic
lateral
sclerosis
(ALS)
lose
voluntary
control,
including
ability
communicate.
For
ALS
patients,
BCI
research
focuses
on
communication.
technology
can
used
a
communication
tool.
It
records
and
extracts
features
signals
translates
these
into
commands
that
replaced,
restored,
enhanced,
supplemented,
or
improved
by
central
nervous
system.
Some
BCIs
been
shown
potential
spillover
for
patients.
However,
there
are
still
some
challenges
need
addressed
before
clinically
useful.
Language: Английский