Co-creating a person-centered creative engagement intervention for Parkinson's care

Frontiers in Psychology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 15, 2025

Recent research in the field of "Arts and Health" has demonstrated beneficial impact arts-based interventions on health well-being across diverse populations. Recognizing their potential, especially cases where conventional healthcare cannot address multifaceted conditions such as Parkinson's disease (PD), our study advocates for an integrative approach medical practice neuroscience. We recommend incorporating learning environments from design phase through long-term care. The arts offer a unique opportunity to create environments. In this study, we specifically focus individuals with PD, co-designing intervention creative engagement environment PD-specific therapy. narratives those affected contribute scientific knowledge, shaping care increasing intervention's relevance participants' lives. used participatory design-based approach. Fourteen along three therapists researchers, collaborated iterative cycles co-develop therapy intervention. Qualitative data were collected interviews, group reflections, ethnographic observations. Data analyzed using reflexive thematic analysis. co-creation process resulted 10-week delivered "creative playground" setting. Participants chose multiple media autonomously decided activities. Guidance was provided needed support individual guide reflection processes. Narratives offered insights into autonomy care, role arts, individuality experience, resulting seven key features framework, which include (i) structure (e.g., duration sessions), (ii) freedom selection media, (iii) playground, (iv) skills therapists, (v) considerations, (vi) financial considerations logistics, list (vii) responsibilities Design Team. This establishes initial framework designed environment. Future will rigorously evaluating its effectiveness exploring scalability settings.

Language: Английский

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Unleashing creativity in people with Parkinson’s disease: a pilot study of a co-designed creative arts therapy

Journal of Neurology, Journal Year: 2025, Volume and Issue: 272(2)

Published: Jan. 23, 2025

Abstract Background Conventional medical management, while essential, cannot address all multifaceted consequences of Parkinson’s disease (PD). This pilot study explores the potential a co-designed creative arts therapy on health-related quality life, well-being, and pertinent non-motor symptoms. Methods We conducted an exploratory with pre-post design using validated questionnaires. Eight individuals PD participated in program. The investigated intervention was 10-week weekly 90–120-min sessions, guided by three therapists. Participants were allowed to autonomously select from multiple media based their personal preferences. Explored co-primary outcomes included life (PDQ-39), well-being (ICECAP-A), anxiety/depression (HADS), executive functioning (BRIEF-A), resilience/mental flexibility (FIT-60), self-efficacy (GSES). used paired sample t tests for pre–post analysis Wilcoxon signed-rank PDQ-39 sub-scores. also aesthetic responsiveness (AReA) healthcare consumption (IMCQ adapted PD) questionnaires reported as descriptive statistics. Results results showed significant reduction anxiety increase well-being. observed slight improvement cognitive functioning. Finally, we noted (fewer visits at neurologists, specialized nurses, allied professionals). Conclusion These findings cautiously suggest that our co-designed, multi-media has reduce anxiety, reducing consumption. preliminary support need larger, randomized controlled trial explore therapeutic care.

Language: Английский

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Predictors of stress resilience in Parkinson’s disease and associations with symptom progression

npj Parkinson s Disease, Journal Year: 2024, Volume and Issue: 10(1)

Published: April 11, 2024

Abstract People with Parkinson’s disease (PD) are sensitive to effects of long-term stress, but might differ in stress resilience, i.e. the ability maintain mental health despite adversity. It is unclear whether resilience PD predominantly determined by dopamine deficiency, psychosocial factors, or both. In animal models, chronic stressors accelerate progression, evidence humans lacking. Our objectives were (1) distinguish stressor-reactive from resilient patients, (2) identify and (3) compare symptom progression between patients. We conducted a longitudinal survey Personalized Parkinson Project participants ( N = 350 PD). used COVID-19 pandemic as model stressor, aligned time for entire cohort. COVID-19-related stressors, perceived symptoms assessed at 11 timepoints (April-October 2020). Both pre-COVID in-COVID clinical assessments available. quantified stressor-reactivity residual actual predicted relative modeled trajectories across timepoints. explored predictors 6-month average stressor-reactivity, tested was prospectively associated one-year rates. Latent class trajectory models distinguished patients high 123) low 227) stressor-reactivity. Pre-existing anxiety, rumination non-motor severity (risk factors), whereas quality life, social support, positive appraisal style cognitive abilities (resilience factors). PD-specific e.g. duration, motor severity, levodopa use, did not predict The worsened depressive

Language: Английский

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Impact of Acute Dopamine Replacement on Cognitive Function in Parkinson's Disease

Movement Disorders Clinical Practice, Journal Year: 2024, Volume and Issue: 11(5), P. 534 - 542

Published: March 12, 2024

Abstract Background PD causes striatal dopaminergic denervation in a posterior/dorsal to anterior/ventral gradient, leaving motor and associative cortico‐striato‐pallido‐thalamic loops differentially susceptible hyperdopaminergic effects with treatment. As the choice titration of symptomatic medications are guided primarily by symptoms, it is important understand their cognitive implications. Objective To investigate acute medication administration on executive function Parkinson's disease (PD). Methods Participants idiopathic were administered oral Symbol Digit Modalities Test (SDMT; n = 181) Stroop test ( 172) off‐medication “best on” states. ANCOVA was used for differences between on‐medication scores corrected age years education. Results After medications, worsened SDMT F 11.70, P < 0.001, d −0.13), improved color 26.89, 0.184), word 6.25, 0.013, 0.09), color‐word 13.22, 0.16) components, difference ratio‐based interference did not significantly change. Longer duration correlated lower SDMT, color, word, scores; however, longer higher levodopa‐equivalents difference‐based scores. Conclusions Symptomatic affects performance two tests PD. treatment, core measures improved, unchanged, worsened, likely reflecting complex changes processing speed related When considering symptom therapies PD, an individual's demands expectations, especially regarding function, should be considered.

Language: Английский

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Dopamine Increases Accuracy and Lengthens Deliberation Time in Explicit Motor Skill Learning

eNeuro, Journal Year: 2024, Volume and Issue: 11(1), P. ENEURO.0360 - 23.2023

Published: Jan. 1, 2024

Although animal research implicates a central role for dopamine in motor skill learning, direct causal link has yet to be established neurotypical humans. Here, we tested if pharmacological manipulation of alters using paradigm which engaged explicit, goal-directed strategies. Participants (27 females; 11 males; aged 18–29 years) first consumed either 100 mg levodopa ( n = 19), precursor that increases availability, or placebo 19). Then, during training, participants learnt the explicit strategy aiming away from presented targets by instructed angles varying sizes. Targets jumped mid-movement angle. Task success was thus contingent upon accuracy and not speed. The effect manipulations on learning assessed training after an overnight follow-up. Increasing availability at improved lengthened reaction times, particularly larger, more difficult angles, both and, importantly, follow-up, despite prominent session-by-session performance improvements Exogenous seems result learnt, persistent propensity better adhere task goals. Results support proposal is important engagement instrumental motivation optimize adherence goals, when execute strategies learning.

Language: Английский

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Evidence for absence of links between striatal dopamine synthesis capacity and working memory capacity, spontaneous eye-blink rate, and trait impulsivity

eLife, Journal Year: 2023, Volume and Issue: 12

Published: April 20, 2023

Individual differences in striatal dopamine synthesis capacity have been associated with working memory capacity, trait impulsivity, and spontaneous eye-blink rate (sEBR), as measured readily available easily administered, ‘off-the-shelf’ tests. Such findings raised the suggestion that individual variation estimated expensive invasive brain positron emission tomography (PET) scans, can be approximated simple, more pragmatic However, direct evidence for relationship between these simple measures has limited inconclusive. We using [ 18 F]-FDOPA PET a large sample of healthy volunteers (N = 94) assessed correlation short tests sEBR. additionally explored an index subjective reward sensitivity. None correlated significantly nor did they out-of-sample predictive power. Bayes factor analyses indicated was favour absence correlations all but These results warrant caution off-the-shelf proxies capacity.

Language: Английский

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Impulse control disorder in Parkinson’s disease is associated with abnormal frontal value signalling

Brain, Journal Year: 2023, Volume and Issue: 146(9), P. 3676 - 3689

Published: May 16, 2023

Abstract Dopaminergic medication is well established to boost reward- versus punishment-based learning in Parkinson’s disease. However, there tremendous variability dopaminergic effects across different individuals, with some patients exhibiting much greater cognitive sensitivity than others. We aimed unravel the mechanisms underlying this individual a large heterogeneous sample of early-stage disease as function comorbid neuropsychiatric symptomatology, particular impulse control disorders and depression. One hundred ninety-nine (138 ON 61 OFF medication) 59 healthy controls were scanned functional MRI while they performed an probabilistic instrumental task. Reinforcement model-based analyses revealed group differences from gains losses, but only disorders. Furthermore, expected-value related brain signalling ventromedial prefrontal cortex was increased compared those medication, striatal reward prediction error remained unaltered. These data substantiate hypothesis that dopamine’s on reinforcement vary disorder suggest reflect deficient computation value medial frontal cortex, rather striatum. See Michael Browning (https://doi.org/10.1093/brain/awad248) for scientific commentary article.

Language: Английский

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Dopaminergic modulation and dosage effects on brain state dynamics and working memory component processes in Parkinson’s disease

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 11, 2025

Parkinson's disease (PD) is primarily diagnosed through its characteristic motor deficits, yet it also encompasses progressive cognitive impairments that profoundly affect quality of life. While dopaminergic medications are routinely prescribed to manage symptoms in PD, their influence extends functions as well. Here we investigate how medication influences aberrant brain circuit dynamics associated with encoding, maintenance and retrieval working memory (WM) task-phases processes. PD participants, both on off medication, healthy controls, performed a Sternberg WM task during fMRI scanning. We employ Bayesian state-space computational model delineate state related different phases. Importantly, within-subject design allows us examine individual differences the effects performance. find alters connectivity within prefrontal-basal ganglia-thalamic circuits, changes correlating enhanced Dopaminergic restores engagement task-phase-specific states, enhancing Critically, identify an "inverted-U-shaped" relationship between dosage, dynamics, Our study provides valuable insights into dynamic neural mechanisms underlying dopamine treatment response paving way for more personalized therapeutic strategies. Lee et al. demonstrate medication-induced spatiotemporal correlate performance gains participants disease.

Language: Английский

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Understanding disrupted motivation in Parkinson’s disease through a value-based decision-making lens

Trends in Neurosciences, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Prevalence of experienced changes in artistic and everyday creativity in people with Parkinson’s disease

npj Parkinson s Disease, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 27, 2025

Abstract Creativity is the ability to generate novel and meaningful ideas or behaviors, encompassing both artistic originality personal satisfaction. Emerging evidence suggests that people with Parkinson’s disease (PD) may experience changes in creativity. This study examines prevalence of creativity PD using cross-sectional data from Netherlands (PRIME-NL, 2021–2023). Participants ( N = 793) self-reported changes, demographics, clinical factors, pre-diagnosis creative engagement via a self-structured questionnaire. Descriptive analyses revealed 41% respondents reported changes: 12% experienced an increase, 22% decrease, 7% fluctuations. Ordinal regression analysis showed longer duration dopamine agonists were associated increased creativity, while older age prior predicted decreases. A sub-cohort n 292) across seven domains, most frequently observed everyday sports/movement, fine art/design. These findings underscore need for further research on inform person-centered treatment strategies.

Language: Английский

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