Cited by A systematic review of the factors associated with the psychological wellbeing of people with Parkinson’s in the COVID-19 pandemic

Alpha-synuclein-induced stress sensitivity renders the Parkinson’s disease brain susceptible to neurodegeneration DOI

Modestos Nakos Bimpos,

Katerina Karali,

Christine Antoniou

et al.

Acta Neuropathologica Communications, Journal Year: 2024, Volume and Issue: 12(1)

Published: June 17, 2024

Abstract A link between chronic stress and Parkinson’s disease (PD) pathogenesis is emerging. Ample evidence demonstrates that the presynaptic neuronal protein alpha-synuclein (asyn) closely tied to PD pathogenesis. However, it not known whether system dysfunction present in PD, if asyn involved, if, together, they contribute neurodegeneration. To address these questions, we assess axis function transgenic rats overexpressing full-length wildtype human (asyn BAC rats) perform multi-level phenotyping following corticosterone administration. Stress signaling, namely corticotropin-releasing factor, glucocorticoid mineralocorticoid receptor gene expression, also examined post-mortem patient brains. Overexpression of leads HPA dysregulation rats, while administration significantly aggravates nigrostriatal degeneration, serine129 phosphorylated (pS129) expression neuroinflammation, leading phenoconversion from a prodromal an overt motor phenotype. Interestingly, induces robust, twofold increase pS129 hypothalamus, master regulator response, hippocampus, both target elevated levels altered markers signalling. Finally, defective hippocampal signalling mirrored brains correlates with levels. Taken our results brain provide circulating glucocorticoids can asyn-induced neurodegeneration, ultimately triggering PD.

Language: Английский

Citations

Psychological stress associated with prognostic uncertainties in recently diagnosed Parkinson’s disease patients: A qualitative study DOI

Yasmin H. Aboelzahab,

Azadeh Bojmehrani,

Y Ahmed

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(3), P. e0319576 - e0319576

Published: March 11, 2025

Background Parkinson’s disease (PD) is a common neurodegenerative disorder that negatively impacts thousands of patients in Canada. The unexpected nature PD associated with decline mental health. highest level psychological stress occurs during the early years following diagnosis. Objectives To understand prognostic uncertainties recently diagnosed patients, uncover gaps current support systems, and recommend areas for improvement services aim to decrease receiving Methods An exploratory qualitative study was conducted using semi-structured interviews 13 more than 6 months less 5 years. Participants were recruited from Toronto Western Hospital Movement Disorders Clinic, Toronto, Ontario, Canada until saturation key themes reached. Results Five major identified capturing lived experiences diagnosis: 1) circumstances diagnosis its impact on 2) intrapersonal factors journey, 3) role social relationships patient’s life, 4) interaction different elements healthcare system, 5) available patients. Conclusions This uncovers burden faced by due insufficient systems. It emphasizes importance patient-centered approach improving their quality life through personalized services.

Language: Английский

Citations

DRN-SNc serotonergic circuit drives stress-induced motor deficits and Parkinson’s disease vulnerability DOI

Yibo Yao, Chi Cui,

Yulong Shi

et al.

Neuropsychopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Language: Английский

Citations

Study protocol for the MIND-PD study: a randomized controlled trial to investigate clinical and biological effects of mindfulness-based cognitive therapy in people with Parkinson’s disease DOI

Anouk van der Heide, Franziska Goltz, Nienke M. de Vries

et al.

BMC Neurology, Journal Year: 2024, Volume and Issue: 24(1)

Published: June 25, 2024

Abstract Background People with Parkinson’s disease (PD) are very sensitive to the effects of stress. The prevalence stress-related neuropsychiatric symptoms is high, and acute stress worsens motor symptoms. Animal studies suggest that chronic may accelerate progression, but evidence for this in humans lacking. Mindfulness-based interventions (MBIs) train participants focus on present moment, purpose without judgement. Previous MBIs alleviate reduce depression anxiety PD. We aim demonstrate efficacy Mindfulness-Based Cognitive Therapy (MBCT) as a non-pharmacologic treatment strategy (and motor) PD, identify mechanisms underlying reduction Methods In prospective randomized controlled trial (RCT), we investigate whether 8 weeks MBCT, compared care usual, can people include 124 PD patients, who experience mild-moderate depression, eligible magnetic resonance imaging (MRI) naïve mindfulness, have duration ≤ 10 years. Every participant followed 12 months. Clinical biochemical assessments take place at baseline (T0), after 2 months (T1), (T2); MRI T0 T2. Our primary outcome total score Hospital Anxiety Depression Scale (HADS) T1, while correcting HADS T0, age, gender. Beyond testing MBCT explore MBCT: (1) has an effect symptom severity, (2) influences cerebral markers stress, (3) leads change biomarkers progression. Discussion MIND-PD one first RCTs 1-year follow-up possible Insight into these pave way new methods future. Trial registration ClinicalTrials.gov, NCT05779137. Registered January 2023.

Language: Английский

Citations

Evidence for a causal-mechanistic role for positive appraisal style in stress resilience DOI

Papoula Petri‐Romão, Roberto Mediavilla, Alexandra Restrepo

et al.

Published: May 20, 2024

Stress resilience is the maintenance of mental health despite adversity. We have predicted that a tendency to appraise stressors in realistic slightly unrealistically positive fashion (positive appraisal style, PAS) prospectively associated with more resilient outcomes; PAS proximal and integrative factor, mediating pro-resilience effects other protective factors (e.g., social support); modifiable, changes leading corresponding resilience. In two independent observational samples (N=132 N=1034), we find predict over three years mediate support. Analyzing multi-component intervention (N=232) targets broad set factors, increases this mediates intervention-induced This establishes as plastic factor likely causal on

Language: Английский

Citations

The MIND-PD study: a randomized controlled trial to investigate clinical and biological effects of Mindfulness-Based Cognitive Therapy in people with Parkinson’s disease DOI

Anouk van der Heide, Franziska Goltz, Nienke M. de Vries

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: June 26, 2024

Abstract Background People with Parkinson’s disease (PD) are very sensitive to the effects of stress. The prevalence stress-related neuropsychiatric symptoms is high, and acute stress worsens motor symptoms. Animal studies suggest that chronic may accelerate progression, but evidence for this in humans lacking. Mindfulness-based interventions (MBIs) train participants focus on present moment, purpose without judgement. Previous MBIs alleviate reduce depression anxiety PD. We aim demonstrate efficacy Mindfulness-Based Cognitive Therapy (MBCT) as a non-pharmacologic treatment strategy (and motor) PD, identify mechanisms underlying reduction Methods In prospective randomized controlled trial (RCT), we investigate whether 8 weeks MBCT, compared care usual, can people include 124 PD patients, who experience mild-moderate depression, eligible magnetic resonance imaging (MRI) naïve mindfulness, have duration ≤ 10 years. Every participant followed 12 months. Clinical biochemical assessments take place at baseline (T0), after 2 months (T1), (T2); MRI T0 T2. Our primary outcome total score Hospital Anxiety Depression Scale (HADS) T1, while correcting HADS T0, age, gender. Beyond testing MBCT explore MBCT: (1) has an effect symptom severity, (2) influences cerebral markers stress, (3) leads change biomarkers progression. Discussion MIND-PD one first RCTs 1-year follow-up possible Insight into these pave way new methods future. Trial registration: ClinicalTrials.gov, NCT05779137. Registered January 2023.

Language: Английский

Citations

Experiences of Living With the Nonmotor Symptoms of Parkinson's Disease: A Photovoice Study DOI

Laura J. Smith, J. J. Callis,

Shannon Bridger‐Smart

et al.

Health Expectations, Journal Year: 2024, Volume and Issue: 27(3)

Published: June 1, 2024

Nonmotor symptoms (NMSs) are frequently experienced by people with Parkinson's disease (PD) and often perceived as their most bothersome symptoms. However, these remain poorly understood suboptimal clinical management. These unmet needs an important determinant of health-related quality life (QoL) in PD.

Language: Английский

Citations

Survey on Parkinson’s Disease Diagnosis Impact: Patients, Caregivers and Health Care Professionals’ Perspectives DOI

Stela Dodaj, Margherita Fabbri, Anne Doé de Maindreville

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(14), P. 4118 - 4118

Published: July 14, 2024

Background: The announcement of Parkinson’s disease (PD) diagnosis may provoke negative feelings that impact the ability to cope with and all life changes related this new condition. There are scarce data on how improve communication about PD which factors influence outcome. Methods: We performed a national French survey, investigating large population people living (PwPD), who recently received (≤1 year since diagnosis), caregivers health care professionals (HCPs), from tertiary community-based hospitals. Results: A total 397 PwPD (45% female 82% > 50 years old), 192 120 HCPs (69% neurologists) completed questionnaire. was not expected by 60% induced in majority (82%) them. Negative experience moment were male gender [OR = 2.034, CI 95% 1.09–3.78; p 0.025] older age 1.05, 1.01–1.08; 0.004], while tremor as first symptom had threshold significance 1.78, 0.994–3.187; 0.052]. Half considered they did receive enough information one third short-term appointment rediscuss diagnosis. expressed willingness have multidisciplinary follow-up (PD nurse, psychologists). Only 24% been trained for announcement. Conclusions: way is delivered represents pivotal journey caregivers. This process requires improvement addressing gaps PwPD, caregivers, through participatory approach.

Language: Английский

Citations

The PRIME-NL study: evaluating a complex healthcare intervention for people with Parkinson’s disease in a dynamic environment DOI

Bart R. Maas,

Robin van den Bergh,

Sanne W. van den Berg

et al.

BMC Neurology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Aug. 3, 2024

An innovative, integrative care model for people with Parkinson (PRIME Parkinson) has gradually been implemented in a selected region of the Netherlands since 2021. A prospective evaluation this (PRIME-NL study) was initiated parallel, spanning year prior to implementation (baseline) and period. Following publication original study protocol, COVID-19 crisis delayed full PRIME by two years hampered recruitment participants.

Language: Английский

Citations

A systematic review of the factors associated with the psychological wellbeing of people with Parkinson’s in the COVID-19 pandemic DOI

H. Gotheridge,

Fiona Eccles, Craig Murray

et al.

Disability and Rehabilitation, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 12

Published: Sept. 11, 2024

The lockdown and social distancing measures introduced as a result of the COVID-19 pandemic impacted ability people with Parkinson's to engage in normal health management practices. This led documented reductions psychological wellbeing. aim present review was identify factors associated wellbeing during acute stage pandemic.

Language: Английский

Citations