An organic state trace element solution for rheumatoid arthritis treatment by modulating macrophage phenotypic from M1 to M2

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 170, P. 116025 - 116025

Published: Dec. 18, 2023

Trace elements (TEs) are essential for the treatment of rheumatoid arthritis (RA). This study aimed to prepare a TEs solution enriched with various organic states evaluate its preventive, therapeutic effects, and mechanism action in RA provide method treatment. The natural ore were extracted added 0.5% (W/V) L-alanyl-L-glutamine (LG) obtain (LG-WLYS), which was examined concentration quality. antioxidant properties effects LG-WLYS on cell behavior evaluated at cellular level. preventive rats explored. clear, free from visible foreign matter, had pH 5.33 an osmolality 305.67 mOsmol/kg. inhibited migration angiogenesis. induced macrophages change M1-type M2-type, increased content enzymes (glutathione, superoxide dismutase, IL-10), decreased levels nitric oxide, malondialdehyde, TNF-α, IL-1β, IL-6, COX-2, iNOs, scavenging reactive oxygen species lesion site, inhibiting apoptosis chondrocytes, regulating inflammatory microenvironment, decreasing inflammation response exert effect RA. In conclusion, has outstanding against enormous potential further development.

Language: Английский

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The Association Between Psoriasis and Trace Element Serum Levels and Dietary Intake: Results from USA National Health and Nutrition Examination Survey 2011–2014

Clinical Cosmetic and Investigational Dermatology, Journal Year: 2024, Volume and Issue: Volume 17, P. 1449 - 1458

Published: June 1, 2024

Psoriasis is a common chronic inflammatory disease. However, trace elements are essential to biochemical processes of the skin, it suspected that vital in pathogenesis psoriasis. Our research aimed investigate association between serum levels and dietary intake selenium, zinc, copper with

Language: Английский

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Calcium Carbonate Microspheres Loaded the Iron and Selenopeptide Conjugate with Human-Like Collagen Scaffold for Skin Filling and Gastric Cancer Therapy

ACS Applied Polymer Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 23, 2024

Language: Английский

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Green Biosynthesized Selenium Nanoparticles Using Whole Cell and Cell Lysate of Spirulina platensis: Characterizations and In Vitro Wound Healing Studies

BioNanoScience, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 11, 2024

Language: Английский

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