Doxorubicin Incorporation into Gold Nanoparticles: An In Vivo Study of Its Effects on Cardiac Tissue in Rats DOI Creative Commons
Patricia Lorena Cîmpan, Camelia Alexandra Coadă, Adrian Florea

et al.

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(20), P. 1647 - 1647

Published: Oct. 14, 2024

Gold nanoparticles (Au-NPs) have been explored as potential vectors for enhancing the antitumor efficacy of doxorubicin (DOX) while minimizing its cardiotoxic effects. However, impacts DOX Au-NPs on cardiac function and oxidative stress remain inadequately understood. This study aimed to explore effects in comparison free DOX, focusing markers, inflammation, ultrastructural changes, function. Male rats were divided into following four groups: control, citrate Au-NPs, Au-NPs. Cardiac was assessed using echocardiography, evaluated through Nrf2, malondialdehyde (MDA) superoxide dismutase (SOD) levels, GSH/GSSG ratio. The ultrastructure tissue by transmission electron microscopy (TEM). Rats treated with exhibited significant dysfunction, indicated a reduction fractional shortening ejection fraction. Oxidative including elevated MDA levels reduced ratio, significantly worse Au-NP group. SOD decreased, indicating compromised antioxidant defenses. Citrate also caused some alterations but without other molecular alterations. failed mitigate cardiotoxicity, instead exacerbating dysfunction. possess effects, necessitating further investigation alternative nanoparticle formulations or therapeutic combinations ensure both safety cancer treatment.

Language: Английский

NADPH Oxidases in Cancer Therapy-Induced Cardiotoxicity: Mechanisms and Therapeutic Approaches DOI

Ayat Hussein Adhab,

Farag M. A. Altalbawy,

Morug Salih Mahdi

et al.

Cardiovascular Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Language: Английский

Citations

0
Doxorubicin-Induced Cardiac Remodeling: Mechanisms and Mitigation Strategies DOI
Yingpu Sun, Lili Xiao, Linlin Chen

et al.

Cardiovascular Drugs and Therapy, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Language: Английский

Citations

0
Doxorubicin Incorporation into Gold Nanoparticles: An In Vivo Study of Its Effects on Cardiac Tissue in Rats DOI Creative Commons
Patricia Lorena Cîmpan, Camelia Alexandra Coadă, Adrian Florea

et al.

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(20), P. 1647 - 1647

Published: Oct. 14, 2024

Gold nanoparticles (Au-NPs) have been explored as potential vectors for enhancing the antitumor efficacy of doxorubicin (DOX) while minimizing its cardiotoxic effects. However, impacts DOX Au-NPs on cardiac function and oxidative stress remain inadequately understood. This study aimed to explore effects in comparison free DOX, focusing markers, inflammation, ultrastructural changes, function. Male rats were divided into following four groups: control, citrate Au-NPs, Au-NPs. Cardiac was assessed using echocardiography, evaluated through Nrf2, malondialdehyde (MDA) superoxide dismutase (SOD) levels, GSH/GSSG ratio. The ultrastructure tissue by transmission electron microscopy (TEM). Rats treated with exhibited significant dysfunction, indicated a reduction fractional shortening ejection fraction. Oxidative including elevated MDA levels reduced ratio, significantly worse Au-NP group. SOD decreased, indicating compromised antioxidant defenses. Citrate also caused some alterations but without other molecular alterations. failed mitigate cardiotoxicity, instead exacerbating dysfunction. possess effects, necessitating further investigation alternative nanoparticle formulations or therapeutic combinations ensure both safety cancer treatment.

Language: Английский

Citations

0