Chemosensors,
Journal Year:
2024,
Volume and Issue:
12(7), P. 136 - 136
Published: July 11, 2024
The
rapid
spread
of
SARS-COV-2
and
the
millions
worldwide
deaths
hospitalizations
have
prompted
an
urgent
need
for
development
screening
tests
capable
rapidly
accurately
detecting
virus,
even
in
asymptomatic
people.
easy
collection
biomarker
content
saliva,
together
with
label-free
informative
power
surface-enhanced
Raman
spectroscopy
(SERS)
analysis
driven
creation
point-of-care
platforms
identifying
people
COVID-19.
Indeed,
different
salivary
fingerprints
were
observed
between
uninfected
infected
Hence,
we
performed
a
retrospective
SERS
spectra
from
samples
COVID-19-infected
-vaccinated
subjects
to
understand
if
viral
components
and/or
immune
response
are
implicated
spectral
variations.
high
sensitivity
proposed
SERS-based
method
highlighted
persistence
molecular
alterations
saliva
up
one
month
after
first
positive
swab,
when
subject
tested
negative
antigenic
test.
Nevertheless,
no
specific
patterns
attributable
some
proteins
immunoglobulins
involved
COVID-19
infection
its
progression
found,
differences
peak
intensity,
presence,
position
fingerprint.
Applied Spectroscopy Reviews,
Journal Year:
2023,
Volume and Issue:
59(2), P. 157 - 186
Published: Jan. 20, 2023
Various
diseases
have
seriously
threatened
the
health
of
Chinese
residents.
Sensitive
and
accurate
analysis
disease
markers
is
very
important
for
early
diagnosis,
treatment,
prognosis
evaluation
diseases.
Therefore,
it
great
clinical
significance
to
explore
a
sensitive,
accurate,
rapid,
noninvasive
detection
technology.
Surface-enhanced
Raman
spectroscopy
(SERS)
uses
light
interact
with
gold,
silver,
other
nanostructured
materials
generate
strong
surface
plasmon
resonance
effect,
which
can
significantly
enhance
signal
molecules
adsorped
on
surface,
obtain
rich
fingerprints
sample
itself
or
probe
super
sensitivity.
This
technology
has
advantages
noninvasiveness,
high
sensitivity,
good
selectivity,
fast
speed,
low
water
interference,
unique
advantages,
so
application
prospect
in
life
science,
testing,
aspects,
become
kind
biological
potential.
paper
mainly
reviewed
research
progress
SERS
serum,
urine,
saliva,
tissue
recent
years
analyzed
problems
challenges
be
solved
by
this
prospected
its
future
development
prospects.
Journal of Vacuum Science & Technology A Vacuum Surfaces and Films,
Journal Year:
2025,
Volume and Issue:
43(3)
Published: April 3, 2025
In
response
to
the
global
need
for
rapid
and
precise
detection
techniques
biomolecules,
particularly
highlighted
by
COVID-19
pandemic,
this
study
explores
application
of
surface-enhanced
Raman
spectroscopy
(SERS)
fluorescent
dyes
proteins.
Using
nanoparticles
synthesized
via
magnetron
sputter
inert
gas
condensation,
we
deposited
copper,
silver,
platinum,
gold,
their
bimetallic
combinations
on
glass
microfiber
filters
used
as
3D
substrates.
Nanoparticles
with
sizes
ranging
from
1.5
8
nm
were
investigated
assess
effect
sensitivity.
Our
results
indicate
that
silver
nanoparticles,
an
average
size
approximately
4–5
nm,
perform
best
among
all
metals
SERS,
significantly
enhancing
The
successfully
demonstrates
effectiveness
SERS
in
detecting
analytes
such
rhodamines
bovine
serum
albumin
at
very
low
concentrations
(down
10−9
mol/l
Rhodamine
6G).
findings
underscore
potential
environmental
monitoring
diagnostics,
highlighting
importance
nanoparticle
optimization
achieving
high
sensitivity,
specificity,
reliability
analytical
detection.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(2), P. 573 - 573
Published: Jan. 6, 2023
Density
functional
theory
(DFT)
calculations
allow
us
to
reproduce
the
SERS
(surface-enhanced
Raman
scattering)
spectra
of
molecules
adsorbed
on
nanostructured
metal
surfaces
and
extract
most
information
this
spectroscopy
is
potentially
able
provide.
The
latter
point
mainly
concerns
anchoring
mechanism
bond
strength
between
molecule
as
well
structural
electronic
modifications
molecule.
These
findings
are
fundamental
importance
for
application
spectroscopic
technique.
This
review
presents
discusses
some
SERS–DFT
studies
carried
out
in
Italy
a
collaboration
universities
Modena
Reggio-Emilia
Florence,
giving
an
overview
that
we
can
with
combination
experimental
DFT
modeling.
In
addition,
selection
recent
advancements
approach
reported
commentary.
