Developing a nanomaterial-based 3D-printed platform: Application as a cancer aptasensor via detection of heat shock protein 90 (HSP90)

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 409, P. 135592 - 135592

Published: March 4, 2024

Language: Английский

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Two sides of the same coin: heat shock proteins as biomarkers and therapeutic targets for some complex diseases

Frontiers in Molecular Biosciences, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 20, 2025

Heat shock proteins are molecular chaperones that play crucial roles in the folding and unfolding of complex polypeptides within cellular system. These molecules involved various processes, including vesicular transport, prevention protein aggregation cytosol, cell signaling. They also linked to autoimmunity, infection immunity, tumor immunology. Stressors like heat shock, exposure heavy metals, cytokines, reactive oxygen species, inflammation, viruses can influence production these molecules. In diseases such as cancer, malaria, COVID-19, considered both biomarkers drug targets. The upregulation small hsp27 major 70/90 has been recognized therapeutic targets for cancer. Additionally, it reported invasion Plasmodium falciparum, causative agent leads hsp40, hsp70, hsp90. This sudden increase is a protective mechanism from human host enhances parasite's growth, making significant malarial presence SARS-CoV-2 virus system correlates with substantial 70 cells. Furthermore, our research group demonstrated hijacks host's proteins, we currently developing tools prevent utilizing review aims highlight role selected refractory diseases, focusing on COVID-19. A fundamental docking study was performed investigate interaction between non-structural chosen molecules, which emphasized this review.

Language: Английский

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Automated synthesis and processing of functional nanomaterials: Advances and perspectives

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 523, P. 216249 - 216249

Published: Oct. 11, 2024

Language: Английский

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Aptasensing of beta-amyloid (Aβ(1−42)) by a 3D-printed platform integrated with leaf-shaped gold nanodendrites

Sensors and Actuators B Chemical, Journal Year: 2023, Volume and Issue: 393, P. 134130 - 134130

Published: June 12, 2023

Language: Английский

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Sandwich-like electrochemical immunosensing of IL-17 based on silver nanoparticles/graphdiyne and methylene blue/UiO-66-NH2

Microchimica Acta, Journal Year: 2025, Volume and Issue: 192(5)

Published: April 17, 2025

Language: Английский

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A novel label-free electrochemical immunosensor for the detection of heat shock protein 70 of lung adenocarcinoma cell line following paclitaxel treatment using l-cysteine-functionalized Au@MnO₂/MoO₃ nanocomposites

RSC Advances, Journal Year: 2023, Volume and Issue: 13(43), P. 29847 - 29861

Published: Jan. 1, 2023

The future trend in achieving precision medicine involves the development of non-invasive cancer biomarker sensors that offer high accuracy, low cost, and time-saving benefits for risk clarification, early detection, disease therapeutic monitoring. A facile approach synthesis MoO3 nanosheets was developed by thermally oxidizing MoS2 air followed thermal annealing. Subsequently, Au@MnO2 nanocomposites were prepared using a combined hydrothermal process situ chemical synthesis. In this study, we present novel immunosensor design strategy involving immobilization antiHSP70 antibodies on Au@MnO2/MoO3 modified screen-printed electrode (SPE) EDC/NHS chemistry. This study establishes HSP70 as potential monitoring response during anticancer therapy. Impedance measurements Au@MnO2/MoO3/SPE EIS showed an increase impedance with concentration. electrochemical demonstrated good linear range 0.001 to 1000 ng mL-1 detection limit 0.17 pg under optimal conditions. Moreover, effective detecting at concentrations lung adenocarcinoma cell line following Paclitaxel treatment, indicating its organ-on-a-chip clinical applications.

Language: Английский

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Supramolecular Sensing Platforms: Techniques for In Vitro Biosensing

ChemEngineering, Journal Year: 2024, Volume and Issue: 8(4), P. 66 - 66

Published: June 28, 2024

Supramolecular chemistry is a relatively new field of study that utilizes conventional chemical knowledge to produce edges smart materials. One such material use supramolecular the development sensing platforms. Biologically relevant molecules need frequent assessment both qualitatively and quantitatively explore several biological processes. In this review, we have discussed techniques with key examples kinds bio-analytes tried cast light on how molecular design can help in making Moreover, these materials been finally used as platforms has well. Several useful spectroscopic, microscopic, visible, electronic outcomes sensor discussed, special emphasis device-based applications. This kind comprehensive discussion necessary widen scope technology.

Language: Английский

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Recent advances in electrochemical aptasensors and genosensors for the detection of pathogens

Environmental Research, Journal Year: 2023, Volume and Issue: 243, P. 117850 - 117850

Published: Dec. 9, 2023

Language: Английский

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Sandwich-Like Electrochemical Immunosensing of Squamous Cell Carcinoma Antigen Based on Gold Nanoparticles/Reduced Graphene and Toluidine Blue/UIO-66-NH₂

Journal of The Electrochemical Society, Journal Year: 2024, Volume and Issue: 171(3), P. 037526 - 037526

Published: Jan. 19, 2024

Squamous cell carcinoma antigen (SCCA) is an important biomarker in the diagnose of cancer, so developing effective methods for its detection great significance. In present work, a novel sandwich-like electrochemical immunosensing assay (STEM) SCCA was constructed by preparing gold nanoparticle/reduced graphene-oxide (Au NPs/rGO) to immobilize primary antibody (PAb) and UIO-66-NH 2 MOFs structure second (SAb) electroactive toluidine blue (Tb) probe. this designed STEM assay, prepared Au NPs/rGO nanohybrid offers advantages large surface area conductivity as carrier, provided ideal platform accommodate SAb number Tb molecules signal amplifier. existence SCCA, current peaks from formed increase with level. After optimizing related control factors, wide linear range (0.01 pg ml −1 15.0 ng ) very low limit (0.003 achieved, it’s thus expected strategy has applications SCCA.

Language: Английский

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Label-free determination of glypican-3 using PtPd@H-rGO nanocomposites decorated light-addressable potentiometric sensor

Bioelectrochemistry, Journal Year: 2024, Volume and Issue: 162, P. 108855 - 108855

Published: Nov. 27, 2024

Language: Английский

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