Increasing the sensitivity and accuracy of detecting exosomes as biomarkers for cancer monitoring using optical nanobiosensors

Cancer Cell International, Journal Year: 2024, Volume and Issue: 24(1)

Published: May 30, 2024

Abstract The advancement of nanoscience and material design in recent times has facilitated the creation point-of-care devices for cancer diagnosis biomolecule sensing. Exosomes (EXOs) facilitate transfer bioactive molecules between cells diverse local distant microenvironments, thereby contributing to progression metastasis. Specifically, EXOs derived from are likely function as biomarkers early detection due genetic or signaling alterations they transport payload within origin. It been verified that circulate steadily bodily secretions contain a variety information indicates tumor. However, acquiring molecular interactions regarding presented significant technical challenges their nanoscale nature high heterogeneity. Colorimetry, surface plasmon resonance (SPR), fluorescence, Raman scattering examples optical techniques utilized quantify exosomal biomarkers, including lipids, proteins, RNA, DNA. Many optically active nanoparticles (NPs), predominantly carbon-based, inorganic, organic, composite-based nanomaterials, have employed biosensing technology. exceptional physical properties exhibited by carbon NPs, noble metal magnetic progress development nanobiosensors intended originating tumors. Following summary biogenesis, biological functions, biomarker value known EXOs, this article provides an update on methodologies currently under investigation. In conclusion, we propose some potential enhancements biosensors detecting EXO, utilizing various NP materials such silicon graphene oxide (GO), quantum dots (QDs).

Language: Английский

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Exosomal integrins in tumor progression, treatment and clinical prediction (Review)

International Journal of Oncology, Journal Year: 2024, Volume and Issue: 65(6)

Published: Nov. 13, 2024

Integrins are a large family of cell adhesion molecules involved in tumor differentiation, migration, proliferation and neovascularization. Tumor cell‑derived exosomes carry number integrins, which closely associated with progression. As crucial mediators intercellular communication, exosomal integrins have gained attention the field cancer biology. The present review examined regulatory mechanisms proliferation, migration invasion, emphasized their notable roles initiation potential as drug delivery systems treatment was explored. Additionally, clinical prediction considered, while summarizing applications diagnosis, prognosis assessment response prediction. Thus, aimed to provide guidance insights for future basic research translation integrins. study is poised offer new perspectives methods precise

Language: Английский

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Terminal deoxynucleotidyl transferase (TdT) based template-free signal amplification for the detection of exosomes in MUC1-positive cells

Journal of Pharmaceutical and Biomedical Analysis, Journal Year: 2024, Volume and Issue: unknown, P. 116539 - 116539

Published: Oct. 1, 2024

Language: Английский

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A simple capillary isoelectric focusing method as the novel strategy for the isoelectric point measurement of exosomes and its application in disease diagnosis

Microchimica Acta, Journal Year: 2024, Volume and Issue: 192(1)

Published: Dec. 5, 2024

Language: Английский

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