Dynamic contrast‑enhanced MRI combined with intravoxel incoherent motion in quantitative evaluation for preoperative risk stratification of resectable rectal adenocarcinoma DOI Open Access
Yaqiong Chai,

Yongchao Niu,

Rui-xue Cheng

et al.

Oncology Letters, Journal Year: 2024, Volume and Issue: 29(2)

Published: Nov. 20, 2024

Rectal adenocarcinoma is a common malignant tumor of the digestive tract. However, it difficult to obtain microstructural information using conventional magnetic resonance imaging (MRI). Dynamic contrast‑enhanced (DCE)‑MRI and intravoxel incoherent motion (IVIM) have been used in research. The present study aimed explore application DCE‑MRI IVIM risk stratification resectable rectal adenocarcinoma. To achieve this, 75 patients with confirmed via postoperative pathological examination who underwent high‑resolution MRI, DCE‑diffusion‑weighted before surgery were retrospectively enrolled divided into very low‑risk (19 cases), (29 cases) medium‑risk (27 groups. quantitative parameters obtained GenIQ Medical Imaging Interaction Toolkit software, respectively. One‑way analysis variance or Kruskal‑Wallis H test analyze differences measured between different Receiver operating characteristic curves diagnostic efficacy each parameter. rate constant (Kep), perfusion fraction (f) false diffusion coefficient (D*) groups statistically significant (P<0.05). When low‑ compared, f + D* had highest efficiency [area under curve (AUC)=0.719], sensitivity specificity 100 51.70%, Kep (AUC=0.602), 72.41 55.56%, (AUC=0.887), 70.4%, Thus, can aid prognostic adenocarcinoma, Kep, are potential for

Language: Английский

Circulating and Magnetic Resonance Imaging Biomarkers of Intestinal Fibrosis in Small Bowel Crohn’s Disease DOI
Jonathan R. Dillman, Jean A. Tkach, Joel G. Fletcher

et al.

Inflammatory Bowel Diseases, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Abstract Background We previously identified circulating and MRI biomarkers associated with the surgical management of Crohn’s disease (CD). Here we tested associations between these ileal resection inflammation collagen content. Methods Fifty CD patients undergoing were prospectively enrolled at 4 centers. Circulating CD64, extracellular matrix protein 1 (ECM1), GM-CSF autoantibodies (GM-CSF Ab), fecal calprotectin measured by ELISA. Ileal 3-dimensional magnetization transfer ratio (3D MTR), modified Look-Locker inversion recovery (MOLLI) T1 relaxation, diffusion-weighted intravoxel incoherent motion (IVIM), simplified magnetic resonance index activity (sMaRIA) MRI. specimen acute was graded, content quantitatively using second harmonic imaging microscopy. Associations tested. Results Median (interquartile range [IQR]) age 19.5 (16-33) years. observed an inverse relationship (r = −0.39 [95% confidence interval {CI}: −0.61, −0.10], P .008). Most (33 [66%]) received biologics, no variation in treatment exposures. In univariate analysis, Ab, calprotectin, sMaRIA positively negatively (P &lt; .1). The multivariable model for (R2 0.31 CI: 0.11, 0.52]) included log CD64 (β −.27; .19), ECM1 .47; .06), Ab −.15; .01), IVIM f .29, .10), D* 1.69, .13). Conclusions Clinically available exploratory are degree versus fibrosis resections. With further validation, may be used to guide medical decision-making refractory CD.

Language: Английский

Citations

0
Computed tomography enterography-based radiomics nomograms to predict inflammatory activity for ileocolonic Crohn’s disease: a preliminary single-center retrospective study DOI Creative Commons

Yuping Ma,

Luanxin Zhu,

Bota Cui

et al.

BMC Medical Imaging, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 27, 2025

This study aims to develop and validate nomograms that utilize morphological radiomics features derived from computed tomography enterography (CTE) evaluate inflammatory activity in patients with ileocolonic Crohn's disease (CD). A total of 54 CD (237 bowel segments) clinically confirmed were retrospectively analyzed. The Simple Endoscopic Score for Disease (SES-CD) was used as a reference standard quantify the degree mucosal inflammation assess severity. We extracted training cohort create model (M-score) (Rad-score). combined nomogram generated by integrating M-score Rad-score. predictive performance each evaluated using receiver operating characteristic (ROC) curve analysis. Additionally, calibration decision analysis (DCA) employed accuracy clinical applicability testing cohort. area under ROC (AUC) nomogram, which included stenosis, comb sign, Rad-score, 0.834 [95% confidence interval (CI): 0.728–0.940] distinguishing between active remissive disease. Furthermore, created sign Rad-score achieved satisfactory AUC 0.781 (95% CI: 0.611–0.951) differentiating mild moderate-to-severe activity. DCA both nomograms' utility. Nomograms CTE-based could serve valuable tools assessing activity, thereby supporting decision-making managing CD. Keypoints. 1. Radiomics CTE predict 2. most effective predicting 3. enhanced radiologists' ability

Language: Английский

Citations

0
Accelerated T2-weighted MRI of the bowel at 3T using a single-shot technique with deep learning-based image reconstruction: impact on image quality and disease detection DOI
Bari Dane, Barun Bagga,

Bhavik Bansal

et al.

Academic Radiology, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 1, 2024

Language: Английский

Citations

2
Quantitative Magnetic Resonance Imaging (qMRI) of the Small Bowel in Crohn's Disease: State‐of‐the‐Art and Future Directions DOI Creative Commons
Naomi Sakai, Timothy Bray, Stuart A. Taylor

et al.

Journal of Magnetic Resonance Imaging, Journal Year: 2024, Volume and Issue: unknown

Published: July 6, 2024

Crohn's disease (CD) is a chronic inflammatory of the gastrointestinal tract in which repeated episodes acute inflammation may lead to long‐term bowel damage. Cross‐sectional imaging used conjunction with endoscopy diagnose and monitor detect complications. Magnetic resonance (MRI) has demonstrable utility evaluating activity. However, subjective interpretation conventional MR sequences limited its ability fully phenotype underlying histopathological processes disease. In particular, MRI can be confounded by presence mural fibrosis muscle hypertrophy, mask or sometimes mimic inflammation. Quantitative (qMRI) methods provide means better differentiate from improve quantification these processes. qMRI also more objective measures activity enable tailoring treatment. Here, we review quantitative for small CD consider path their clinical translation. Level Evidence 2 Technical Efficacy Stage

Language: Английский

Citations

1
Dynamic contrast‑enhanced MRI combined with intravoxel incoherent motion in quantitative evaluation for preoperative risk stratification of resectable rectal adenocarcinoma DOI Open Access
Yaqiong Chai,

Yongchao Niu,

Rui-xue Cheng

et al.

Oncology Letters, Journal Year: 2024, Volume and Issue: 29(2)

Published: Nov. 20, 2024

Rectal adenocarcinoma is a common malignant tumor of the digestive tract. However, it difficult to obtain microstructural information using conventional magnetic resonance imaging (MRI). Dynamic contrast‑enhanced (DCE)‑MRI and intravoxel incoherent motion (IVIM) have been used in research. The present study aimed explore application DCE‑MRI IVIM risk stratification resectable rectal adenocarcinoma. To achieve this, 75 patients with confirmed via postoperative pathological examination who underwent high‑resolution MRI, DCE‑diffusion‑weighted before surgery were retrospectively enrolled divided into very low‑risk (19 cases), (29 cases) medium‑risk (27 groups. quantitative parameters obtained GenIQ Medical Imaging Interaction Toolkit software, respectively. One‑way analysis variance or Kruskal‑Wallis H test analyze differences measured between different Receiver operating characteristic curves diagnostic efficacy each parameter. rate constant (Kep), perfusion fraction (f) false diffusion coefficient (D*) groups statistically significant (P<0.05). When low‑ compared, f + D* had highest efficiency [area under curve (AUC)=0.719], sensitivity specificity 100 51.70%, Kep (AUC=0.602), 72.41 55.56%, (AUC=0.887), 70.4%, Thus, can aid prognostic adenocarcinoma, Kep, are potential for

Language: Английский

Citations

0